{"id":"naltrexone-tablet-and-nicotine-patch","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Skin irritation at patch site"},{"rate":null,"effect":"Insomnia"},{"rate":null,"effect":"Anxiety"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Naltrexone is an opioid antagonist that blocks mu-opioid receptors, reducing the rewarding effects of nicotine and other substances and decreasing cravings. The nicotine patch delivers steady-state nicotine transdermally to manage withdrawal symptoms and support smoking cessation. Together, they address both the pharmacological dependence and reward-seeking behavior associated with nicotine addiction.","oneSentence":"This combination uses naltrexone to block opioid receptors and reduce cravings while nicotine patch provides nicotine replacement to support smoking cessation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:34:56.662Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Smoking cessation support"},{"name":"Nicotine dependence"}]},"trialDetails":[{"nctId":"NCT00000437","phase":"PHASE4","title":"Tobacco Dependence in Alcoholism Treatment (Nicotine Patch/Naltrexone)","status":"COMPLETED","sponsor":"The Scripps Research Institute","startDate":"1997-09-26","conditions":"Alcoholism, Smoking","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Revia and Nicotrol"],"phase":"marketed","status":"active","brandName":"Naltrexone Tablet and Nicotine Patch","genericName":"Naltrexone Tablet and Nicotine Patch","companyName":"The Scripps Research Institute","companyId":"the-scripps-research-institute","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination uses naltrexone to block opioid receptors and reduce cravings while nicotine patch provides nicotine replacement to support smoking cessation. Used for Smoking cessation support, Nicotine dependence.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}