{"id":"nalorphine","rwe":[],"tags":[{"label":"nalorphine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Mu-type opioid receptor","category":"target"},{"label":"OPRM1","category":"gene"},{"label":"OPRK1","category":"gene"},{"label":"SIGMAR1","category":"gene"},{"label":"V03AB02","category":"atc"},{"label":"Active","category":"status"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Narcotic Antagonists","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Sensory System Agents","category":"pharmacology"}],"phase":"marketed","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"nalorphin","offLabel":[],"synonyms":["nalorphine","allorphine","antorphine","lethidrone","N-Allylnormorphine","nalorphin","nalorphine hydrochloride","nalorphine HCl"],"timeline":[],"aiSummary":"Nalorphine, also known as NALORPHINE, is a small molecule drug that targets the mu-type opioid receptor. It belongs to the nalorphine class and was originally developed by an unknown entity. The commercial status of nalorphine is unclear, and it is not FDA-approved for any indications. As a result, there is limited information available on its safety profile and clinical use. Further research is needed to determine the potential therapeutic applications and risks associated with nalorphine.","approvals":[{"date":"","orphan":false,"company":"","regulator":"FDA"}],"brandName":"Nalorphin","ecosystem":[],"mechanism":{"target":"Delta-type opioid receptor, Kappa-type opioid receptor, Mu-type opioid receptor","novelty":"First-in-class","targets":[{"gene":"OPRM1","source":"DrugCentral","target":"Mu-type opioid receptor","protein":"Mu-type opioid receptor"},{"gene":"OPRK1","source":"DrugCentral","target":"Kappa-type opioid receptor","protein":"Kappa-type opioid receptor"},{"gene":"SIGMAR1","source":"DrugCentral","target":"Sigma non-opioid intracellular receptor 1","protein":"Sigma non-opioid intracellular receptor 1"},{"gene":"OPRD1","source":"DrugCentral","target":"Delta-type opioid receptor","protein":"Delta-type opioid receptor"}],"modality":"Small Molecule","drugClass":"nalorphine","explanation":"Think of the mu-type opioid receptor like a lock on a door. Nalorphine is a key that can either open the door (activating the receptor) or block the lock (blocking the receptor). This dual action can have different effects on the body, depending on the specific situation.","oneSentence":"Nalorphine works by binding to the mu-type opioid receptor, which can either activate or block the receptor depending on the specific configuration of the molecule.","technicalDetail":"Nalorphine exhibits a mixed agonist-antagonist activity at the mu-type opioid receptor, which can lead to complex pharmacological effects, including analgesia, dysphoria, and respiratory depression."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1877","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=NALORPHINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:53:31.772579","biosimilars":[],"competitors":[{"drugName":"pralidoxime","drugSlug":"pralidoxime","fdaApproval":"1964-03-11","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"prednisolone","drugSlug":"prednisolone","fdaApproval":"1955-06-21","genericCount":42,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"promethazine","drugSlug":"promethazine","fdaApproval":"1951-03-29","genericCount":48,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"sodium 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