{"id":"naftin-1-cream","safety":{"commonSideEffects":[{"rate":null,"effect":"Local irritation (burning, stinging, erythema)"},{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Dryness"}]},"_chembl":{"chemblId":"CHEMBL2108947","moleculeType":"Unknown"},"_fixedAt":"2026-03-30T18:27:58.451971","_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Naftifine is an allylamine-class antifungal that selectively inhibits squalene epoxidase, an enzyme critical for ergosterol synthesis in fungal cell membranes. By depleting ergosterol and accumulating toxic sterol precursors, it causes fungal cell membrane instability and death. It has broad-spectrum activity against dermatophytes, yeasts, and some non-dermatophyte molds.","oneSentence":"Naftin (naftifine) is a topical antifungal that inhibits fungal sterol synthesis by blocking squalene epoxidase, disrupting the fungal cell membrane.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:22:31.545Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Tinea pedis (athlete's foot)"},{"name":"Tinea cruris (jock itch)"},{"name":"Tinea corporis (ringworm)"}]},"_fixedFields":["pubmed(5)"],"trialDetails":[{"nctId":"NCT01885156","phase":"PHASE3","title":"Evaluation of Efficacy and Safety of Naftin 1% Cream in Adolescent Subjects With Tinea Cruris","status":"COMPLETED","sponsor":"Merz North America, Inc.","startDate":"2013-08","conditions":"Tinea Cruris, Jock Itch","enrollment":65},{"nctId":"NCT01580891","phase":"PHASE1","title":"Evaluate the Clinical Equivalence of Two Naftifine HCl 1% Creams in Patients With Interdigital Tinea Pedis","status":"COMPLETED","sponsor":"Sun Pharmaceutical Industries, Inc.","startDate":"2012-05","conditions":"Tinea Pedis","enrollment":1053},{"nctId":"NCT00750139","phase":"PHASE3","title":"Multicenter Study of the Safety and Efficacy of NAFT-500 in Tinea Pedis","status":"COMPLETED","sponsor":"Merz North America, Inc.","startDate":"2008-08","conditions":"Tinea Pedis, Athlete's Foot","enrollment":707}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":5,"recentPublications":[{"date":"2011 Nov","pmid":"22052309","title":"A randomized, double-blind, vehicle-controlled efficacy and safety study of naftifine 2% cream in the treatment of tinea pedis.","journal":"Journal of drugs in dermatology : JDD"},{"date":"2011 Oct","pmid":"21968664","title":"A double-blind, randomized, vehicle-controlled study evaluating the efficacy and safety of naftifine 2% cream in tinea cruris.","journal":"Journal of drugs in dermatology : JDD"},{"date":"2003 Jan","pmid":"12509578","title":"Persistent and recurrent tinea corporis in children treated with combination antifungal/ corticosteroid agents.","journal":"Pediatrics"},{"date":"1999 Jul","pmid":"10439936","title":"Terbinafine. An update of its use in superficial mycoses.","journal":"Drugs"},{"date":"1991 Sep","pmid":"1938085","title":"Naftifine treatment of trichomycosis pubis.","journal":"International journal of dermatology"}],"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Naftin 1% Cream","genericName":"Naftin 1% Cream","companyName":"Merz North America, Inc.","companyId":"merz-north-america-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Naftin (naftifine) is a topical antifungal that inhibits fungal sterol synthesis by blocking squalene epoxidase, disrupting the fungal cell membrane. Used for Tinea pedis (athlete's foot), Tinea cruris (jock itch), Tinea corporis (ringworm).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}