{"id":"naft600-pediatric","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site pain or bruising"},{"rate":null,"effect":"Muscle weakness"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Flu-like symptoms"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Botulinum toxin works by blocking the release of acetylcholine at the neuromuscular junction, leading to temporary paralysis of targeted muscles. In pediatric applications, it is used to manage conditions characterized by abnormal muscle tone or involuntary movements. The effect is localized to injected muscles and is reversible over several months.","oneSentence":"NAFT600 is a botulinum toxin product used to reduce muscle contractions and treat movement disorders in pediatric patients.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:34:49.681Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Pediatric spasticity"},{"name":"Pediatric movement disorders"}]},"trialDetails":[{"nctId":"NCT01712360","phase":"PHASE4","title":"Pharmacokinetic Study of Pediatric Subjects With Tinea Cruris and Tinea Pedis","status":"COMPLETED","sponsor":"Merz North America, Inc.","startDate":"2012-10","conditions":"Tinea Pedis, Tinea Cruris","enrollment":56}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":437110,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["NAFT600","naftifine","naftifine hydrochloride"],"phase":"marketed","status":"active","brandName":"NAFT600 (pediatric)","genericName":"NAFT600 (pediatric)","companyName":"Merz North America, Inc.","companyId":"merz-north-america-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"NAFT600 is a topical antifungal agent that disrupts fungal cell membrane integrity by inhibiting ergosterol synthesis. Used for Tinea pedis (athlete's foot) in pediatric patients, Tinea cruris (jock itch) in pediatric patients, Tinea corporis (ringworm) in pediatric patients.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}