{"id":"naft600-adult","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Injection site pain or bruising"},{"rate":null,"effect":"Eyelid ptosis"},{"rate":null,"effect":"Brow ptosis"},{"rate":null,"effect":"Muscle weakness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Botulinum toxin type A irreversibly cleaves SNARE proteins required for acetylcholine vesicle release, leading to temporary paralysis of injected muscles. This mechanism is used therapeutically to reduce dynamic wrinkles and treat various conditions involving muscle hyperactivity. The effect is temporary, typically lasting 3-4 months, after which neuromuscular function gradually recovers.","oneSentence":"NAFT600 is a botulinum toxin type A preparation that blocks acetylcholine release at the neuromuscular junction to reduce muscle contractions.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:56:32.773Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Temporary improvement of moderate to severe glabellar lines (frown lines) in adults"},{"name":"Temporary improvement of moderate to severe lateral canthal lines (crow's feet) in adults"}]},"trialDetails":[{"nctId":"NCT01712360","phase":"PHASE4","title":"Pharmacokinetic Study of Pediatric Subjects With Tinea Cruris and Tinea Pedis","status":"COMPLETED","sponsor":"Merz North America, Inc.","startDate":"2012-10","conditions":"Tinea Pedis, Tinea Cruris","enrollment":56}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1049325,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["NAFT600","naftifine","naftifine hydrochloride"],"phase":"marketed","status":"active","brandName":"NAFT600 (adult)","genericName":"NAFT600 (adult)","companyName":"Merz North America, Inc.","companyId":"merz-north-america-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"NAFT600 is a botulinum toxin type A preparation that blocks acetylcholine release at the neuromuscular junction to reduce muscle contractions. Used for Temporary improvement of moderate to severe glabellar lines (frown lines) in adults, Temporary improvement of moderate to severe lateral canthal lines (crow's feet) in adults.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}