{"id":"naft-600-naftin-2-gel","safety":{"commonSideEffects":[{"rate":null,"effect":"Local skin irritation"},{"rate":null,"effect":"Burning or stinging at application site"},{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Pruritus"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Naftin works by inhibiting the enzyme squalene epoxidase in the sterol synthesis pathway of fungi, preventing the formation of ergosterol, a critical component of the fungal cell membrane. This disruption of membrane integrity leads to fungal cell death. The drug is effective against a broad spectrum of dermatophytes and other fungal pathogens.","oneSentence":"Naftin is an allylamine antifungal that inhibits fungal sterol synthesis by blocking squalene epoxidase, disrupting the fungal cell membrane.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:50:20.029Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Fungal skin infections (dermatophyte infections, tinea pedis, tinea cruris, tinea corporis)"}]},"trialDetails":[{"nctId":"NCT01290341","phase":"PHASE3","title":"Evaluation of the Efficacy and Safety of NAFT-600 in Subjects With Tinea Pedis","status":"COMPLETED","sponsor":"Merz North America, Inc.","startDate":"2011-02","conditions":"Tinea Pedis","enrollment":860},{"nctId":"NCT01289015","phase":"PHASE3","title":"Efficacy and Safety of NAFT-600 in Subjects With Tinea Pedis","status":"COMPLETED","sponsor":"Merz North America, Inc.","startDate":"2011-02","conditions":"Tinea Pedis","enrollment":855}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Naftin®"],"phase":"phase_3","status":"active","brandName":"NAFT-600 ( naftin 2 % gel )","genericName":"NAFT-600 ( naftin 2 % gel )","companyName":"Merz North America, Inc.","companyId":"merz-north-america-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Naftin is an allylamine antifungal that inhibits fungal sterol synthesis by blocking squalene epoxidase, disrupting the fungal cell membrane. Used for Fungal skin infections (dermatophyte infections, tinea pedis, tinea cruris, tinea corporis).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}