{"id":"nadoxolol","rwe":[{"pmid":"12818235","year":"2003","title":"Kinetic resolution of 1-chloro-3-(1-naphthyloxy)-2-propanol, an intermediate in the synthesis of beta-adrenergic receptor blockers.","finding":"","journal":"Bioorganic chemistry","studyType":"Clinical Study"},{"pmid":"7866535","year":"1994","title":"Determination of nadoxolol in human plasma using reversed-phase high-performance liquid chromatography.","finding":"","journal":"Journal of chromatography. B, Biomedical applications","studyType":"Clinical Study"},{"pmid":"7872014","year":"1994","title":"Chromatographic analysis (TLC) aprindine and nadoxolol in human plasma.","finding":"","journal":"Acta poloniae pharmaceutica","studyType":"Clinical Study"},{"pmid":"1828772","year":"1991","title":"Acute generalized exanthematic pustulosis. An atypical case due to nadoxolol?","finding":"","journal":"Dermatologica","studyType":"Clinical Study"},{"pmid":"2986092","year":"1985","title":"[Peripheral neuropathy during treatment with nadoxolol].","finding":"","journal":"Presse medicale (Paris, France : 1983)","studyType":"Clinical Study"}],"tags":[{"label":"nadoxolol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["nadoxolol","nadoxolol hydrochloride","nadoxolol HCl"],"offLabel":[],"synonyms":["nadoxolol","nadoxolol hydrochloride","nadoxolol HCl"],"timeline":[],"approvals":[],"ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"nadoxolol","explanation":"Think of it like a volume control for your heart. When you're stressed or excited, your body releases epinephrine, which makes your heart beat faster. Nadoxolol helps slow down your heart rate by blocking the effects of epinephrine, making it easier to manage conditions like high blood pressure or heart disease.","oneSentence":"Nadoxolol is a beta-adrenergic receptor blocker that works by blocking the effects of the hormone epinephrine, also known as adrenaline.","technicalDetail":"Nadoxolol is a non-selective beta-adrenergic receptor antagonist that inhibits the effects of epinephrine and norepinephrine on beta-1 and beta-2 adrenergic receptors, leading to decreased heart rate, blood pressure, and cardiac output."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1866","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=NADOXOLOL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:52:35.189139","biosimilars":[],"competitors":[],"genericName":"nadoxolol","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"005307","UNII":"SK43HU1689","CHEBI":"CHEBI:135071","INN_ID":"3322","RXNORM":"236178","UMLSCUI":"C0068353","ChEMBL_ID":"CHEMBL357513","PUBCHEM_CID":"6328253","SECONDARY_CAS_RN":"35991-93-6","MESH_SUPPLEMENTAL_RECORD_UI":"C006154"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":8,"therapeuticAreas":["Nephrology"],"biosimilarFilings":[],"recentPublications":[{"date":"2003 Jun","pmid":"12818235","title":"Kinetic resolution of 1-chloro-3-(1-naphthyloxy)-2-propanol, an intermediate in the synthesis of beta-adrenergic receptor blockers.","journal":"Bioorganic chemistry"},{"date":"1994 Oct 14","pmid":"7866535","title":"Determination of nadoxolol in human plasma using reversed-phase high-performance liquid chromatography.","journal":"Journal of chromatography. B, Biomedical applications"},{"date":"1994","pmid":"7872014","title":"Chromatographic analysis (TLC) aprindine and nadoxolol in human plasma.","journal":"Acta poloniae pharmaceutica"},{"date":"1991","pmid":"1828772","title":"Acute generalized exanthematic pustulosis. An atypical case due to nadoxolol?","journal":"Dermatologica"},{"date":"1985 Mar 30","pmid":"2986092","title":"[Peripheral neuropathy during treatment with nadoxolol].","journal":"Presse medicale (Paris, France : 1983)"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"NADOXOLOL","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Nadoxolol is a small molecule. It is also known by the synonyms LL 1530 and Nadoxolol.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}