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It is commonly used in acute neurological emergencies to manage elevated intracranial pressure.","oneSentence":"Hypertonic saline (3% NaCl) increases serum osmolality to draw fluid from intracellular and interstitial spaces into the intravascular compartment, reducing cerebral edema and intracranial pressure.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:50:19.039Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cerebral edema and elevated intracranial pressure"},{"name":"Traumatic brain injury"},{"name":"Acute stroke management"}]},"trialDetails":[{"nctId":"NCT02466971","phase":"PHASE3","title":"Testing the Addition of a New Anti-Cancer Drug, Triapine, to the Usual Chemotherapy Treatment (Cisplatin) During Radiation Therapy for Advanced-stage Cervical and Vaginal Cancers","status":"ACTIVE_NOT_RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2016-05-10","conditions":"Advanced Vaginal Adenocarcinoma, Advanced Vaginal 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