{"id":"nac-bicarbonate","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Bronchospasm"},{"rate":null,"effect":"Gastrointestinal upset"}]},"_chembl":{"chemblId":"CHEMBL2106975","moleculeType":"Small molecule","molecularWeight":"100.11"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"N-acetylcysteine works by breaking disulfide bonds in mucoproteins, thereby reducing mucus thickness and improving clearance. Sodium bicarbonate raises pH to create a less acidic environment that may further facilitate mucus mobilization and reduce airway irritation. This combination is used to improve airway clearance in conditions characterized by thick, tenacious secretions.","oneSentence":"NAC Bicarbonate combines N-acetylcysteine (a mucolytic and antioxidant agent) with sodium bicarbonate to reduce mucus viscosity and neutralize acidic environments in the respiratory tract.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:56:26.309Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic obstructive pulmonary disease (COPD) with excessive mucus production"},{"name":"Cystic fibrosis"},{"name":"Bronchiectasis with thick secretions"}]},"trialDetails":[{"nctId":"NCT01467466","phase":"PHASE3","title":"Prevention of Serious Adverse Events Following Angiography","status":"COMPLETED","sponsor":"VA Office of Research and Development","startDate":"2013-10-07","conditions":"Acute Renal Failure, Kidney Disease, Coronary Artery Disease","enrollment":5177},{"nctId":"NCT07082621","phase":"NA","title":"N Acetylcystene in Treatment of Radiotherapy Induced Oral Mucositis in Oral Cancer Patients","status":"COMPLETED","sponsor":"Hams Hamed Abdelrahman","startDate":"2024-01-15","conditions":"Oral Mucositis","enrollment":40},{"nctId":"NCT06478667","phase":"PHASE3","title":"The Role of Levosimendan as Inotropic Agent in Acute Aluminum Phosphide-induced Cardiotoxicity","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2024-12-20","conditions":"Acute Myocarditis","enrollment":50},{"nctId":"NCT00579995","phase":"NA","title":"A Prospective, Randomized TrialComparing Oral N-Acetylcysteine and Intravenous Sodium Bicarbonate","status":"TERMINATED","sponsor":"University of Nebraska","startDate":"2005-05-01","conditions":"Nephropathy","enrollment":41},{"nctId":"NCT03541187","phase":"PHASE2","title":"Cockroach Immunotherapy in Children and Adolescents","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2018-07-16","conditions":"Persistent Asthma","enrollment":82},{"nctId":"NCT01098032","phase":"PHASE3","title":"RenalGuard System and Contrast Media","status":"COMPLETED","sponsor":"Clinica Mediterranea","startDate":"2009-01","conditions":"Chronic Kidney Disease","enrollment":294},{"nctId":"NCT04755972","phase":"NA","title":"Mucolytics in Patients on Invasive Mechanical Ventilation Due to Severe Acute Respiratory Syndrome Coronavirus 2","status":"COMPLETED","sponsor":"Clinical Hospital Center, Split","startDate":"2020-10-01","conditions":"Corona Virus Infection, Pneumonia, Ventilator-Associated","enrollment":175},{"nctId":"NCT04509258","phase":"PHASE4","title":"Effectiveness of N-acetyl Cysteine, Acetyl L- Carnitine and Medicated Paraffin Oil in Aluminium Phosphide Poisoning","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2020-10","conditions":"the Study Focus to Improve the Standard of Care Used for Aluminuim Phosphide Poisoning and to Save Patients With the Minimal Organ Damage","enrollment":100},{"nctId":"NCT02476526","phase":"PHASE4","title":"Safety of Low Dose IV Contrast CT Scanning in Chronic Kidney Disease","status":"COMPLETED","sponsor":"VA Greater Los Angeles Healthcare System","startDate":"2008-09","conditions":"Chronic Kidney Disease, Pulmonary Embolism, Renal Artery Stenosis","enrollment":50},{"nctId":"NCT02761577","phase":"PHASE4","title":"A Prospective Study on Incidence and Prevention of Contrast-induced Nephropathy in Croatia","status":"COMPLETED","sponsor":"Clinical Hospital Centre Zagreb","startDate":"2012-06","conditions":"Kidney Diseases, Contrast Media Reaction","enrollment":90},{"nctId":"NCT02483143","phase":"PHASE4","title":"NAC, NaHCO3 and NS Prophylaxis for CTPA in the ED on Suspicion of PE: A Randomized Controlled Trial","status":"COMPLETED","sponsor":"Karadeniz Technical University","startDate":"2014-02","conditions":"Radiographic Contrast Agent Nephropathy, Pulmonary Embolism","enrollment":231},{"nctId":"NCT01218178","phase":"","title":"Sodium Bicarbonate and N-Acetylcysteine for Nephroprotection in Acute Myocardial Infarction","status":"COMPLETED","sponsor":"Catholic University of the Sacred Heart","startDate":"2008-06","conditions":"Acute Myocardial Infarction, Acute Kidney Injury","enrollment":520},{"nctId":"NCT01210456","phase":"PHASE3","title":"Efficacy Trial of N-Acetylcysteine and Sodium Bicarbonate for the Prevention of Contrast-Induced Acute Kidney Injury","status":"UNKNOWN","sponsor":"Tokushukai Medical Group","startDate":"2009-10","conditions":"Chronic Kidney Disease","enrollment":458},{"nctId":"NCT00497328","phase":"PHASE2, PHASE3","title":"COmbined N-acetylcysteine and Bicarbonate in PCI To Reduce Adverse Side Effect of contrasT","status":"COMPLETED","sponsor":"National University Hospital, Singapore","startDate":"2007-08","conditions":"Contrast Induced Nephropathy","enrollment":477},{"nctId":"NCT01160627","phase":"NA","title":"Prevention of Contrast-induced Nephropathy in Patients With Acute Myocardial Infarction","status":"COMPLETED","sponsor":"Odense University Hospital","startDate":"2010-04","conditions":"Contrast Induced Nephropathy","enrollment":720},{"nctId":"NCT01612013","phase":"NA","title":"Intravenous High Dose NAC and Sodium Bicarbonate for the Prevention of Contrast-induced Acute Injury","status":"COMPLETED","sponsor":"Federal University of São Paulo","startDate":"2005-05","conditions":"Acute Renal Failure","enrollment":500},{"nctId":"NCT00501475","phase":"PHASE4","title":"NAC in Preventing CIN in CRF Patients Who Need Enhanced CT Scan in ED","status":"UNKNOWN","sponsor":"Seoul National University Hospital","startDate":"2007-03","conditions":"Chronic Renal Failure","enrollment":""},{"nctId":"NCT00353340","phase":"NA","title":"Prevention of Contrast Nephropathy by Sodium Bicarbonate Versus Sodium Chloride and N-acetylcysteine","status":"COMPLETED","sponsor":"Shaare Zedek Medical Center","startDate":"2005-01","conditions":"Acute Renal Failure Contrast Nephropathy","enrollment":250},{"nctId":"NCT00716001","phase":"PHASE4","title":"Effect of Hydration With Sodium Bicarbonate for Long-Term Clinical Outcomes in Patients With Chronic Kidney Disease Undergoing an Emergent Coronary Procedure","status":"UNKNOWN","sponsor":"Osaka General Medical Center","startDate":"2008-07","conditions":"Chronic Renal Failure","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":65,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"NAC Bicarbonate","genericName":"NAC Bicarbonate","companyName":"Seoul National University Hospital","companyId":"seoul-national-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"NAC (N-acetylcysteine) combined with bicarbonate works by providing antioxidant support and alkalinizing urine to reduce nephrotoxicity and improve renal protection. Used for Prevention of contrast-induced nephropathy in patients undergoing radiographic procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}