{"id":"nabilone-flexible-dosing","safety":{"commonSideEffects":[{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Drowsiness"},{"rate":null,"effect":"Dry mouth"},{"rate":null,"effect":"Euphoria or dysphoria"},{"rate":null,"effect":"Ataxia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Nabilone acts as a partial agonist at CB1 and CB2 cannabinoid receptors, which are distributed throughout the brain and peripheral tissues. By activating these receptors, it modulates neurotransmitter release and reduces pain signaling, nausea, and other symptoms. The flexible dosing approach allows individualized titration to optimize therapeutic benefit while minimizing adverse effects.","oneSentence":"Nabilone is a synthetic cannabinoid that mimics THC and activates cannabinoid receptors in the central nervous system to modulate pain, nausea, and other symptoms.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:22:33.173Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chemotherapy-induced nausea and vomiting (CINV)"},{"name":"Chronic pain conditions"}]},"trialDetails":[{"nctId":"NCT01035281","phase":"PHASE3","title":"Efficacy Study of Nabilone in the Treatment of Diabetic Peripheral Neuropathic Pain","status":"UNKNOWN","sponsor":"University of Calgary","startDate":"2008-01","conditions":"Diabetic Neuropathies","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Cesamet"],"phase":"phase_3","status":"active","brandName":"Nabilone, flexible dosing","genericName":"Nabilone, flexible dosing","companyName":"University of Calgary","companyId":"university-of-calgary","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Nabilone is a synthetic cannabinoid that mimics THC and activates cannabinoid receptors in the central nervous system to modulate pain, nausea, and other symptoms. Used for Chemotherapy-induced nausea and vomiting (CINV), Chronic pain conditions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}