{"id":"n2o-exposure","safety":{"commonSideEffects":[{"rate":"20-30","effect":"Nausea and vomiting"},{"rate":"10-20","effect":"Dizziness"},{"rate":"5-15","effect":"Headache"},{"rate":null,"effect":"Vitamin B12 depletion (with chronic exposure)"},{"rate":null,"effect":"Peripheral neuropathy (with chronic abuse)"}]},"_chembl":{"chemblId":"CHEMBL2106388","moleculeType":"Small molecule","molecularWeight":"74.09"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"N2O acts primarily as a non-competitive NMDA receptor antagonist, blocking excitatory glutamatergic neurotransmission. It also enhances inhibitory GABAergic signaling and modulates opioid and monoamine systems. These combined effects produce rapid onset anesthesia, analgesia, and anxiolysis with minimal respiratory depression at sub-anesthetic doses.","oneSentence":"Nitrous oxide (N2O) is an inhaled anesthetic gas that depresses the central nervous system by modulating NMDA receptors and other ion channels to produce anesthesia and analgesia.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:56:22.813Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"General anesthesia (induction and maintenance)"},{"name":"Analgesia and anxiolysis in acute care and procedural settings"},{"name":"Dental anesthesia"},{"name":"Emergency pain relief"}]},"trialDetails":[{"nctId":"NCT05528718","phase":"","title":"SMILE Trial - Imaging Sub-Study","status":"COMPLETED","sponsor":"Unity Health Toronto","startDate":"2023-03-07","conditions":"Major Depressive Disorder","enrollment":11},{"nctId":"NCT05230784","phase":"NA","title":"The PURI-HF (Air Purifiers on Heart Failure) Trial","status":"RECRUITING","sponsor":"NYU Langone Health","startDate":"2024-03-06","conditions":"Heart Failure","enrollment":255},{"nctId":"NCT07262008","phase":"PHASE3","title":"Sustained Mood Improvement With Laughing Gas Exposure","status":"NOT_YET_RECRUITING","sponsor":"Women's College Hospital","startDate":"2026-02-01","conditions":"Major Depressive Disorder, Treatment Resistant Depression","enrollment":120},{"nctId":"NCT05007028","phase":"NA","title":"Nitrous Oxide for Late-Life Depression - 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8","status":"COMPLETED","sponsor":"University of Chicago","startDate":"1995-08","conditions":"Opioid-Related Disorders, Substance-Related Disorders","enrollment":11},{"nctId":"NCT01098175","phase":"","title":"Peritoneal Cavity Conditioning During Open Surgery.","status":"UNKNOWN","sponsor":"KU Leuven","startDate":"2010-04","conditions":"Laparotomy, Thoracotomy","enrollment":40}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":67,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["N2O"],"phase":"marketed","status":"active","brandName":"N2O exposure","genericName":"N2O exposure","companyName":"Maisonneuve-Rosemont Hospital","companyId":"maisonneuve-rosemont-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Nitrous oxide (N2O) is an inhaled anesthetic gas that depresses the central nervous system by modulating NMDA receptors and other ion channels to produce anesthesia and analgesia. Used for General anesthesia (induction and maintenance), Analgesia and anxiolysis in acute care and procedural settings, Dental anesthesia.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}