{"id":"n-fopam","safety":{"commonSideEffects":[{"rate":null,"effect":"Sweating"},{"rate":null,"effect":"Tachycardia"},{"rate":null,"effect":"Tremor"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Insomnia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Nefopam works primarily by blocking the reuptake of norepinephrine and dopamine at presynaptic terminals, increasing their synaptic concentrations and enhancing pain modulation pathways. Unlike opioids, it does not bind to opioid receptors and has a distinct mechanism that makes it useful as a non-opioid alternative for moderate pain relief. It also has mild anticholinergic and sympathomimetic properties that contribute to its analgesic effects.","oneSentence":"Nefopam is a non-opioid analgesic that inhibits the reuptake of monoamines (norepinephrine, dopamine, and serotonin) in the central nervous system to produce analgesia.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:56:20.603Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Moderate acute and postoperative pain"},{"name":"Chronic pain conditions"}]},"trialDetails":[{"nctId":"NCT00413257","phase":"PHASE2, PHASE3","title":"Effects of Nefopam on Hyperalgesia After Cardiac Surgery","status":"COMPLETED","sponsor":"University Hospital, Bordeaux","startDate":"2006-12","conditions":"Hyperalgesia, Pain, Postoperative, Pain, Chronic Disease","enrollment":90},{"nctId":"NCT00639574","phase":"PHASE4","title":"Nefopam and Morphine Consumption in the Treatment of Ureteral Calculi","status":"COMPLETED","sponsor":"University Hospital, Clermont-Ferrand","startDate":"2008-03","conditions":"Ureteral Calculi, Hyperalgic, Not Complicated","enrollment":52}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"néfopam","genericName":"néfopam","companyName":"University Hospital, Bordeaux","companyId":"university-hospital-bordeaux","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Nefopam is a non-opioid analgesic that inhibits the reuptake of monoamines (norepinephrine, dopamine, and serotonin) in the central nervous system to produce analgesia. Used for Moderate acute and postoperative pain, Chronic pain conditions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}