{"id":"n-acetylglucosamine","rwe":[{"pmid":"41906054","year":"2026","title":"Identification of novel sugar-small-molecule conjugates in human urine based on multi-energy LC-MS/MS analysis.","finding":"","journal":"Analytical and bioanalytical chemistry","studyType":"Clinical Study"},{"pmid":"41877503","year":"2026","title":"Astragalus Polysaccharide Promotes NLRP3(+) Macrophages Polarization via Suppression of OGT in Hepatocellular Carcinoma.","finding":"","journal":"Immunological investigations","studyType":"Clinical Study"},{"pmid":"41856288","year":"2026","title":"The butyrate-producing Gram-positive human gut bacterium, Hoskinsella mucinilytica, selectively targets host mucin N-acetylhexosamines.","finding":"","journal":"The Journal of biological chemistry","studyType":"Clinical Study"},{"pmid":"41850183","year":"2026","title":"N-acetylglucosamine ameliorates the transition from acute kidney injury to chronic kidney disease by reducing the accumulation of lipid droplets.","finding":"","journal":"International immunopharmacology","studyType":"Clinical Study"},{"pmid":"41849190","year":"2026","title":"Revealing and Exploiting the Biochemistry of O-GlcNAc through Protein Semisynthesis.","finding":"","journal":"Biochemistry","studyType":"Clinical Study"}],"tags":[{"label":"N-Acetylglucosamine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Oral","category":"route"},{"label":"Topical","category":"route"},{"label":"Capsule","category":"form"},{"label":"Cream","category":"form"},{"label":"Gel","category":"form"},{"label":"Granule","category":"form"},{"label":"Active","category":"status"}],"phase":"marketed","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"acetylglucosamine","offLabel":[],"synonyms":["N-Acetyl-D-glucosamine","N-Acetylglucosamine","acetylglucosamine"],"timeline":[],"aiSummary":"Acetylglucosamine, also known as N-Acetylglucosamine, is a small molecule drug in the N-Acetylglucosamine class. It is a naturally occurring compound found in the body, involved in various biological processes. However, there is limited information available on its commercial status and approved indications. Further research is needed to determine its efficacy and safety profile. As a result, it is not possible to provide a comprehensive summary of its clinical use.","brandName":"Acetylglucosamine","ecosystem":[],"mechanism":{"target":"Killer cell lectin-like receptor subfamily B member 1A","modality":"Small Molecule","drugClass":"N-Acetylglucosamine","explanation":"Think of glycosaminoglycans like a network of roads in the body. Acetylglucosamine helps to maintain and repair this network, which is important for healthy joints, skin, and other tissues. By doing so, it may help to alleviate symptoms of certain conditions.","oneSentence":"Acetylglucosamine works by interacting with glycosaminoglycans in the body, influencing various biological processes.","technicalDetail":"Acetylglucosamine acts as a substrate for glycosaminoglycan synthesis, influencing the activity of enzymes involved in glycosaminoglycan metabolism, such as glucosamine-6-phosphate isomerase and UDP-glucose dehydrogenase."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/N-Acetylglucosamine","title":"N-Acetylglucosamine","extract":"N-Acetylglucosamine (GlcNAc) is an amide derivative of the monosaccharide glucose. It is a secondary amide between glucosamine and acetic acid. It is significant in several biological systems."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4615","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=N-ACETYLGLUCOSAMINE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=N-ACETYLGLUCOSAMINE","fields":["publications"],"source":"PubMed/NCBI"},{"id":4,"url":"https://en.wikipedia.org/wiki/N-Acetylglucosamine","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T08:19:19.443268","biosimilars":[],"competitors":[],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"n-acetylglucosamine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT07225998","phase":"PHASE2","title":"Oral 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