{"id":"n-acetylcystine-albuterol","safety":{"commonSideEffects":[{"rate":null,"effect":"Tremor"},{"rate":null,"effect":"Tachycardia"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Bronchospasm (paradoxical)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"N-acetylcysteine acts as a mucolytic agent that cleaves mucus glycoproteins, reducing sputum thickness and improving clearance. Albuterol is a short-acting beta-2 agonist that relaxes bronchial smooth muscle, dilating airways. The combination enhances both mucus mobilization and airway patency, facilitating expectoration and gas exchange.","oneSentence":"N-acetylcysteine reduces mucus viscosity by breaking disulfide bonds in mucoproteins, while albuterol bronchodilates airways via beta-2 adrenergic stimulation, together improving airway clearance and breathing.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:56:24.787Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cystic fibrosis"},{"name":"Chronic obstructive pulmonary disease with excessive mucus production"},{"name":"Bronchiectasis"}]},"trialDetails":[{"nctId":"NCT03822637","phase":"PHASE4","title":"The Effect of NAC on Lung Function and CT Mucus Score","status":"TERMINATED","sponsor":"University of California, San Francisco","startDate":"2019-02-20","conditions":"Asthma","enrollment":4},{"nctId":"NCT06152653","phase":"PHASE4","title":"The Effects of Positive Airway Pressure on the Mucolytic Effects of NAC (TEAM)","status":"RECRUITING","sponsor":"University of California, San Francisco","startDate":"2024-04-09","conditions":"Asthma, COPD","enrollment":40},{"nctId":"NCT03346681","phase":"EARLY_PHASE1","title":"N-Acetyl-cysteine in Early Acute Respiratory Distress Syndrome","status":"WITHDRAWN","sponsor":"Prisma Health-Midlands","startDate":"2018-02-01","conditions":"Acute Respiratory Distress Syndrome","enrollment":""},{"nctId":"NCT06095258","phase":"PHASE2","title":"A Practical RCT of TCM in the Treatment of LCOVID and Analysis of Syndrome Types and Medication Characteristics.","status":"UNKNOWN","sponsor":"Chinese University of Hong Kong","startDate":"2023-12-01","conditions":"Long COVID","enrollment":162},{"nctId":"NCT03581084","phase":"PHASE4","title":"Inpatient Clinical Trial of NAC","status":"TERMINATED","sponsor":"University of California, San Francisco","startDate":"2018-07-06","conditions":"Asthma","enrollment":1},{"nctId":"NCT02159196","phase":"NA","title":"Effectiveness of Routine Nebulization of Mucolytics and Bronchodilators During Mechanical Ventilation","status":"COMPLETED","sponsor":"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","startDate":"2014-07","conditions":"Respiratory Failure","enrollment":950},{"nctId":"NCT02818270","phase":"NA","title":"Evaluation of Aerosolized Drugs Deposition During Mechanical Ventilation","status":"COMPLETED","sponsor":"Chang Gung University","startDate":"2016-06","conditions":"Chronic Obstructive Pulmonary Disease","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Mucomyst","NAC","n-acetylcystine"],"phase":"marketed","status":"active","brandName":"n-acetylcystine + albuterol","genericName":"n-acetylcystine + albuterol","companyName":"University of California, San Francisco","companyId":"university-of-california-san-francisco","modality":"Small molecule","firstApprovalDate":"","aiSummary":"N-acetylcysteine reduces mucus viscosity by breaking disulfide bonds in mucoproteins, while albuterol bronchodilates airways via beta-2 adrenergic stimulation, together improving airway clearance and breathing. Used for Cystic fibrosis, Chronic obstructive pulmonary disease with excessive mucus production, Bronchiectasis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}