{"id":"n-acetylcysteine-a","safety":{"commonSideEffects":[{"rate":"5-10","effect":"Nausea"},{"rate":"2-5","effect":"Vomiting"},{"rate":"2-5","effect":"Diarrhea"},{"rate":"1-3","effect":"Rash"},{"rate":null,"effect":"Bronchospasm (rare, in susceptible patients)"}]},"_chembl":null,"_dailymed":{"setId":"61f96b64-0c3c-4c88-92ea-c992dda13e15","title":"CORNISOL EYE WASH DROPS (N-ACETYLCYSTEINE) SOLUTION/ DROPS [ELT SCIENCE CORP]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"N-acetylcysteine (NAC) is a prodrug that is rapidly deacetylated to cysteine, which serves as a precursor for glutathione synthesis, the body's primary intracellular antioxidant. Additionally, NAC directly breaks disulfide bonds in mucoproteins, reducing mucus viscosity and improving clearance. These dual mechanisms make it useful in conditions characterized by oxidative stress, thick secretions, or acetaminophen toxicity.","oneSentence":"N-acetylcysteine replenishes intracellular glutathione and acts as a mucolytic agent to reduce mucus viscosity and support antioxidant defenses.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T05:16:24.133Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic bronchitis with thick secretions"},{"name":"Acetaminophen (paracetamol) overdose"},{"name":"Cystic fibrosis"},{"name":"Chronic obstructive pulmonary disease (COPD)"}]},"trialDetails":[{"nctId":"NCT05142735","phase":"NA","title":"Effects of NAC on Symptoms of CHR Patients","status":"RECRUITING","sponsor":"Centre for Addiction and Mental Health","startDate":"2023-01-13","conditions":"Prodromal Schizophrenia","enrollment":90},{"nctId":"NCT07273071","phase":"PHASE4","title":"Individualized Multiplex Pathophysiological Treatment of Severe Acute Infections: N-Acetylcysteine","status":"NOT_YET_RECRUITING","sponsor":"Theis S. 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STROKE","status":"TERMINATED","sponsor":"University Hospital, Caen","startDate":"2021-06-16","conditions":"Stroke, Ischemic","enrollment":12},{"nctId":"NCT07082621","phase":"NA","title":"N Acetylcystene in Treatment of Radiotherapy Induced Oral Mucositis in Oral Cancer Patients","status":"COMPLETED","sponsor":"Hams Hamed Abdelrahman","startDate":"2024-01-15","conditions":"Oral Mucositis","enrollment":40},{"nctId":"NCT05944458","phase":"PHASE4","title":"Efficacy of Intravenous N-Acetylcysteine in Preventing Linezolid-Induced Thrombocytopenia in Critically Ill Patients","status":"COMPLETED","sponsor":"Helwan University","startDate":"2023-08-01","conditions":"Linezolid, Antioxidant, Thrombocytopenia","enrollment":250},{"nctId":"NCT02804594","phase":"PHASE2","title":"A Study of Oxidative Pathways in MS Fatigue","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2016-10-01","conditions":"Progressive Multiple Sclerosis, 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