{"id":"myrtecaine","rwe":[],"tags":[{"label":"myrtecaine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Potassium voltage-gated channel subfamily H member 2","category":"target"},{"label":"KCNH2","category":"gene"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"nopoxamine","offLabel":[],"synonyms":["myrtecaine","nopoxamine"],"timeline":[],"aiSummary":"Nopoxamine, also known as MYRTECAINE, is a small molecule drug that targets the potassium voltage-gated channel subfamily H member 2. It is classified as a myrtecaine and works by blocking potassium channels, which can help to stabilize heart rhythm. However, its commercial status and approved indications are unknown. As a result, it is not clear if Nopoxamine is patented or available as a generic medication. Further research is needed to determine its safety and efficacy.","approvals":[],"brandName":"Nopoxamine","ecosystem":[],"mechanism":{"target":"Potassium voltage-gated channel subfamily H member 2","targets":[{"gene":"KCNH2","source":"DrugCentral","target":"Potassium voltage-gated channel subfamily H member 2","protein":"Potassium voltage-gated channel subfamily H member 2"}],"modality":"Small Molecule","drugClass":"myrtecaine","explanation":"Imagine your heart is like a firework, with electrical signals that make it beat. Potassium channels help to calm down these signals, but sometimes they get too excited and cause an irregular heartbeat. Nopoxamine blocks these potassium channels, which helps to slow down the electrical signals and keep the heart beating normally.","oneSentence":"Nopoxamine works by blocking potassium channels in the heart to help stabilize heart rhythm.","technicalDetail":"Nopoxamine acts as a selective blocker of the potassium voltage-gated channel subfamily H member 2 (Kv11.1), which is a key regulator of the cardiac action potential."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3787","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=MYRTECAINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:52:07.798949","biosimilars":[],"competitors":[{"drugName":"abemaciclib","drugSlug":"abemaciclib","fdaApproval":"2017-09-28","patentExpiry":"Sep 28, 2031","patentStatus":"Patent 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