{"id":"mycophenolate-mofetil-cap-tab","safety":{"commonSideEffects":[{"rate":"20–40%","effect":"Diarrhea"},{"rate":"10–25%","effect":"Nausea"},{"rate":"10–15%","effect":"Vomiting"},{"rate":"15–25%","effect":"Abdominal pain"},{"rate":"15–25%","effect":"Leukopenia"},{"rate":"10–20%","effect":"Anemia"},{"rate":"20–30%","effect":"Infection (bacterial, viral, fungal)"},{"rate":"10–15%","effect":"Headache"},{"rate":"5–10%","effect":"Tremor"}]},"_chembl":{"chemblId":"CHEMBL1456","moleculeType":"Small molecule","molecularWeight":"433.50"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"MMF is a prodrug that is rapidly hydrolyzed to mycophenolic acid (MPA), which preferentially inhibits IMPDH type II, the predominant isoform in activated lymphocytes. This blocks guanosine nucleotide synthesis required for lymphocyte DNA replication, leading to selective immunosuppression without affecting other cell types as severely. It is used to prevent rejection in transplant recipients and to treat autoimmune conditions.","oneSentence":"Mycophenolate mofetil inhibits inosine monophosphate dehydrogenase (IMPDH), selectively suppressing T and B lymphocyte proliferation to prevent organ rejection and autoimmune responses.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:34:42.825Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of organ rejection in renal, cardiac, and hepatic transplant recipients"},{"name":"Treatment of active lupus nephritis"},{"name":"Treatment of active rheumatoid arthritis (in combination with other agents)"}]},"trialDetails":[{"nctId":"NCT05193565","phase":"PHASE4","title":"Study to Compare the Efficacy and Safety After Conversion to RaparoBell® or My-Rept® in Kidney Transplant Patients","status":"ACTIVE_NOT_RECRUITING","sponsor":"Chong Kun Dang Pharmaceutical","startDate":"2021-11-19","conditions":"Kidney Transplantation","enrollment":206},{"nctId":"NCT03983850","phase":"PHASE1, PHASE2","title":"Optimizing PTCy Dose and Timing","status":"ACTIVE_NOT_RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2019-07-09","conditions":"Graft Versus Host Disease, Hematologic Neoplasms","enrollment":105},{"nctId":"NCT03841097","phase":"PHASE4","title":"Pulse Wave Velocity, Tacrolimus Time in Therapeutic Range and CV in African American Kidney Transplants","status":"ACTIVE_NOT_RECRUITING","sponsor":"Roy D. 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Cancer","enrollment":44},{"nctId":"NCT06044493","phase":"PHASE4","title":"MYREPTIC-N® or MY-REPT® in Stable Patients After Kidney Transplant Recipients","status":"RECRUITING","sponsor":"Chong Kun Dang Pharmaceutical","startDate":"2023-11-15","conditions":"Kidney Transplant","enrollment":158},{"nctId":"NCT02921789","phase":"PHASE2","title":"Study to Assess the Efficacy and Safety of Bleselumab in Preventing the Recurrence of Focal Segmental Glomerulosclerosis in de Novo Kidney Transplant Recipients","status":"COMPLETED","sponsor":"Astellas Pharma Global Development, Inc.","startDate":"2017-05-22","conditions":"Kidney Transplantation, Primary Focal Segmental Glomerulosclerosis (FSGS)","enrollment":67},{"nctId":"NCT03794492","phase":"PHASE4","title":"Impact of Lymphocyte Anti-metabolite Immunosuppressions on Donor-Specific Anti-HLA Antibody and Kidney Graft Outcome","status":"COMPLETED","sponsor":"Chong Kun Dang Pharmaceutical","startDate":"2018-03-31","conditions":"Kidney 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molecule inhibitor of the enzyme inosine-5'-monophosphate dehydrogenase (IMPDH). It is used to treat various conditions, including Chronic Renal Failure, Kidney Transplantation, and Primary Focal Segmental Glomerulosclerosis (FSGS), often in combination with other immunosuppressive agents.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}