{"id":"mupirocin-ointment-treatment","safety":{"commonSideEffects":[{"rate":null,"effect":"Local skin irritation"},{"rate":null,"effect":"Burning or stinging at application site"},{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Pruritus"}]},"_chembl":{"chemblId":"CHEMBL3989715","moleculeType":"Small molecule","molecularWeight":"1075.35"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Mupirocin is a topical antibiotic that selectively inhibits bacterial isoleucyl-tRNA synthetase, an enzyme essential for bacterial protein synthesis. By blocking this enzyme, mupirocin prevents bacteria from synthesizing proteins necessary for survival and replication. This mechanism is bacteriostatic and effective against a broad spectrum of gram-positive and some gram-negative bacteria.","oneSentence":"Mupirocin inhibits bacterial protein synthesis by binding to isoleucyl-tRNA synthetase, preventing bacterial growth and reproduction.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:56:09.249Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Impetigo"},{"name":"Secondary bacterial skin infections"},{"name":"Nasal colonization with methicillin-resistant Staphylococcus aureus (MRSA)"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":263,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Bactroban ointment","Mupirocin 2% in Polyethylene Glycol (PEG) Ointment"],"phase":"marketed","status":"active","brandName":"Mupirocin Ointment [Treatment]","genericName":"Mupirocin Ointment [Treatment]","companyName":"US Department of Veterans Affairs","companyId":"us-department-of-veterans-affairs","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Mupirocin inhibits bacterial isoleucyl-tRNA synthetase, preventing protein synthesis and causing bacteriostatic activity against susceptible bacteria. Used for Impetigo, Infected skin lesions and minor skin infections, Nasal colonization with Staphylococcus aureus (including MRSA).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}