{"id":"multivitamins-vitamins-b-complex-c-and-e","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset (nausea, diarrhea)"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Flushing (from niacin)"}]},"_chembl":{"chemblId":"CHEMBL2068323","moleculeType":"Small molecule","molecularWeight":"516.24"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"B vitamins (B1, B2, B3, B5, B6, B12, folate) function as coenzymes in energy metabolism and nucleic acid synthesis. Vitamin C serves as a reducing agent and cofactor for collagen synthesis and immune function. Vitamin E acts as a lipophilic antioxidant protecting cell membranes from oxidative damage. Together, these vitamins support general health maintenance and may reduce risk of chronic disease.","oneSentence":"B complex, C, and E vitamins act as essential cofactors and antioxidants to support cellular metabolism, energy production, and protection against oxidative stress.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:22:19.100Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Nutritional supplementation and disease prevention in general population"},{"name":"Potential reduction of cardiovascular disease risk"}]},"trialDetails":[{"nctId":"NCT06981936","phase":"PHASE4","title":"This Randomized Trial Aims to Investigate the Efficacy of Balanced Nutritional Tablets-Comprehensive Multivitamin and Mineral Supplements- in Preventing Micronutrient Deficiencies Among Patients Utilizing GLP-1 RAs for Weight Loss in Comparison to a Placebo Control","status":"RECRUITING","sponsor":"General Committee of Teaching Hospitals and Institutes, Egypt","startDate":"2025-05-15","conditions":"Micronutrient Deficiencies","enrollment":150},{"nctId":"NCT05775237","phase":"NA","title":"An Investigator-initiated Trial to Assess the Effectiveness of Three Different Gummies (Curcumin Gummies, Vitamin C Gummies, and Vitamin B Complex Gummies) in Healthy Children","status":"COMPLETED","sponsor":"NovoBliss Research Pvt Ltd","startDate":"2023-05-01","conditions":"Healthy Children","enrollment":48},{"nctId":"NCT03442283","phase":"","title":"Meta-analysis of Randomized Controlled Trials on Vitamins and Mineral Supplementation for CVD Prevention and Treatment","status":"UNKNOWN","sponsor":"University of Toronto","startDate":"2016-07","conditions":"Cardiovascular Diseases","enrollment":1},{"nctId":"NCT00197548","phase":"PHASE3","title":"A Trial of Micronutrients and Adverse Pregnancy Outcomes","status":"COMPLETED","sponsor":"Harvard School of Public Health (HSPH)","startDate":"2001-08","conditions":"Pregnancy, Premature Birth, Infant, Low Birth Weight","enrollment":8468},{"nctId":"NCT00197730","phase":"PHASE3","title":"Trial of Vitamins Among Children of HIV-infected Women","status":"COMPLETED","sponsor":"Harvard School of Public Health (HSPH)","startDate":"2004-06","conditions":"HIV Infections, Pregnancy Complications","enrollment":2387}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Multivitamins - vitamins B complex, C and E","genericName":"Multivitamins - vitamins B complex, C and E","companyName":"Harvard School of Public Health (HSPH)","companyId":"harvard-school-of-public-health-hsph","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Multivitamins containing vitamins B complex, C, and E have been studied in clinical trials for conditions such as pregnancy, premature birth, and micronutrient deficiencies. These trials have investigated the effects of multivitamins on pregnancy outcomes, but the results are not conclusive, as indicated by the completed status of the trial \"A Trial of Micronutrients and Adverse Pregnancy Outcomes\" (NCT00197548).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}