{"id":"multivitamins","rwe":[],"_fda":{"id":"39ed08e8-1c02-d4d1-e063-6394a90af98f","set_id":"2e0e51f3-ee2c-540d-e063-6294a90a9275","openfda":{"nui":["N0000193618","M0001797","M0022797","N0000175952","M0022794","N0000175951","M0022788","N0000175950"],"unii":["WR1WPI7EW8","PQ6CK8PD0R","1C6V77QF41","P6YC3EG204","935E97BOY8","25X51I8RD4","68Y4CF58BV","TLM2976OFR","S033EH8359","8ZYQ1474W7","8K0I04919X","81G40H8B0T"],"route":["ORAL"],"spl_id":["39ed08e8-1c02-d4d1-e063-6394a90af98f"],"brand_name":["Flotrex"],"spl_set_id":["2e0e51f3-ee2c-540d-e063-6294a90a9275"],"package_ndc":["59088-015-54"],"product_ndc":["59088-015"],"generic_name":["MULTIVITAMINS, SODIUM FLUORIDE 0.5 MG"],"product_type":["HUMAN PRESCRIPTION DRUG"],"pharm_class_cs":["Ascorbic Acid [CS]","Vitamin D [CS]","Vitamin B 12 [CS]","Vitamin A [CS]"],"substance_name":[".ALPHA.-TOCOPHEROL ACETATE, DL-","ASCORBIC ACID","CHOLECALCIFEROL","CYANOCOBALAMIN","FOLIC ACID","NIACINAMIDE","PYRIDOXINE HYDROCHLORIDE","RIBOFLAVIN","SODIUM ASCORBATE","SODIUM FLUORIDE","THIAMINE MONONITRATE","VITAMIN A"],"pharm_class_epc":["Vitamin C [EPC]","Vitamin D [EPC]","Vitamin B12 [EPC]","Vitamin A [EPC]"],"manufacturer_name":["PureTek Corporation"],"is_original_packager":[true]},"version":"4","warnings":["WARNING Keep out of the reach of children. In case of accidental overdose, seek professional assistance or contact a Poison Control Center immediately. Caution: Do not eat or drink dairy products within one hour of fluoride administration. Should be chewed. This product, as all chewable tablets, is not recommended for children under age 4 due to risk of choking."],"description":["DESCRIPTION: Active Ingredients: Each Chewable Tablet Contains: Vitamin A (as Retinyl Acetate) ........................................................... 750 mcg RAE Vitamin C (as Ascorbic Acid: 24 mg, Sodium Ascorbate: 36 mg) ................. 60 mg Vitamin D3 (as Cholecalciferol) .................................................... 10 mcg (400 IU) Vitamin E (as DL-alpha Tocopheryl Acetate) .............................................. 6.75 mg Thiamin (as Thiamine Mononitrate) ........................................................... 1.05 mg Riboflavin (as Vitamin B2) ........................................................................... 1.2 mg Niacin (as Niacinamide) ............................................................................ 13.5 mg Vitamin B6 (as Pyridoxine HCl) ................................................................. 1.05 mg Folate (as Folic Acid)....................................... 510 mcg DFE (300 mcg Folic Acid) Vitamin B12 (as Cyanocobalamin) ............................................................. 4.5 mcg Fluoride (as Sodium Fluoride) ..................................................................... 0.5 mg Flotrex™ Multivitamin Chewable plus 0.5 mg Fluoride Tablets Active ingredient for caries prophylaxis: Fluoride as sodium fluoride. Flotrex™ Multivitamin Chewable plus 0.5 mg Fluoride Tablets provide fluoride and ten essential vitamins in a chewable tablet. Other Ingredients: Aspartame, Croscarmellose Sodium, Grape Flavor, Magnesium Stearate, Microcrystalline Cellulose, Stearic Acid (Vegetable), Sucrose, CI 42090 (FD&C Blue No. 1 Aluminum Lake), CI 45410 (Red 27 Lake). Phenylketonurics: Contains Phenylalanine 3.0 mg Per Tablet."],"precautions":["PRECAUTION The suggested dose of Flotrex™ Multivitamin Chewable plus 0.5 mg Fluoride Tablets should not be exceeded, since dental fluorosis may result from continued ingestion of large amounts of fluoride. Before prescribing Flotrex™ Multivitamin Chewable plus 0.5 mg Fluoride Tablets: 1. Determine the fluoride content of the drinking water from all major sources. 2. Make sure the child is not receiving significant amounts of fluoride from other sources such as medications and swallowed toothpaste. 3. Periodically check to make sure that the child does not develop significant dental fluorosis. Folate in doses above 0.1 mg daily may obscure pernicious anemia, in that hematologic remission can occur while neurological manifestations remain progressive.There is a potential danger in administering folate to patients with undiagnosed anemia, since folate may obscure the diagnosis of pernicious anemia by alleviating the hematologic manifestations of the disease while allowing the neurologic complications to progress. This may result in severe nervous system damage before the correct diagnosis is made. Adequate doses of vitamin B12 may prevent, halt, or improve the neurologic changes caused by pernicious anemia. The patient’s medical conditions and consumption of other drugs, herbs, and/or supplements should be considered."],"how_supplied":["HOW SUPPLIED Flotrex™ Multivitamin Chewable plus 0.5 mg Fluoride Tablets are purple-colored, grape-flavored, unscored tablets available by prescription only in bottles of 30 tablets. (NDC: 59088-015-54). Dispense in a tight, light-resistant container with a child-resistant closure, as defined in the USP/NF. All prescription substitutions using this product shall be pursuant to applicable state statutes. This is not an Orange Book product."],"effective_time":"20250714","adverse_reactions":["ADVERSE REACTIONS Folate: Allergic sensitization has been reported following both oral and parenteral administration of folate. Adverse reactions have been reported with specific vitamins and minerals but generally at levels substantially higher than those contained herein. However, allergic and idiosyncratic reactions are possible at lower levels."],"contraindications":["Contraindications: This product is contraindicated in patients with a known hypersensitivity to any of the ingredients. The American Academy of Pediatrics recommends that children up to the age 16, in areas where drinking water contains less than optimal levels of fluoride, receive daily fluoride supplementation. Flotrex™ Multivitamin Chewable plus 0.5 mg Fluoride Tablets provide 0.50 mg fluoride in tablet form for children 6-16 years of age in areas where the drinking water fluoride level is less than 0.3 ppm. Flotrex™ Multivitamin Chewable plus 0.5 mg Fluoride Tablets supply significant amounts of Vitamins A, C, D, E, thiamine, riboflavin, niacin, vitamin B6, vitamin B12, and folate to supplement the diet, and to help assure that nutritional deficiencies of these vitamins will not develop. Thus, in a single easy-to-use preparation, children obtain ten essential vitamins and the important mineral, fluoride. Children using Flotrex™ Multivitamin Chewable plus 0.5 mg Fluoride Tablets regularly should receive semiannual dental examinations. The regular brushing of teeth and attention to good oral hygiene practices are also essential. Flotrex™ Multivitamin Chewable plus 0.5 mg Fluoride Tablets is a prescription product for the clinical dietary management of the metabolic processes of caries prophylaxis and provides supplementation of the diet with ten essential vitamins."],"storage_and_handling":["STORAGE Do not use if bottle seal is broken. Store at controlled room temperature 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature]."],"clinical_pharmacology":["CLINICAL PHARMACOLOGY It is well established that fluoridation of the water supply (1 ppm fluoride) during the period of tooth development leads to a significant decrease in the incidence of dental caries. Flotrex™ Multivitamin Chewable plus 0.5 mg Fluoride Tablets provide sodium fluoride and ten essential vitamins in a chewable tablet. Because the tablets are chewable, they provide a topical as well as systemic source of fluoride. Hydroxyapatite is the principal crystal for all calcified tissue in the human body. The fluoride ion reacts with the hydroxyapatite in the tooth as it is formed to produce the more caries-resistant crystal, fluorapatite. The reaction may be expressed by the equation: Ca 10 (PO 4 ) 6 (OH) 2 + 2F - ------- Ca 10 (PO 4 ) 6 F 2 + 2OH - (Hydroxyapatite) (Fluorapatite) Three stages of fluoride deposition in tooth enamel can be distinguished: 1. Small amounts (reflecting the low levels of fluoride in tissue fluids) are incorporated into the enamel crystals while they are being formed. 2. After enamel has been laid down, fluoride deposition continues in the surface enamel. Diffusion of fluoride from the surface inward is apparently restricted. 3. After eruption, the surface enamel acquires fluoride from the water, food, supplementary fluoride and smaller amounts from saliva."],"indications_and_usage":["INDICATIONS AND USAGE This prescription chewable tablet is indicated for the prevention and treatment of vitamin and fluoride deficiencies in patients at high risk for dental caries and inadequate dietary intake of essential vitamins. It is specifically formulated to support normal growth and development, promote bone and dental health, and aid in the maintenance of overall metabolic and immune function."],"dosage_and_administration":["DOSAGE AND ADMINISTRATION One tablet daily, to be dissolved in the mouth or chewed before swallowing. Do not give a chewable tablet to a child younger than 4 years old."],"spl_product_data_elements":["Flotrex Multivitamins, Sodium Fluoride 0.5 mg SUCROSE CROSCARMELLOSE SODIUM D&C RED NO. 27 FD&C BLUE NO. 1 MAGNESIUM STEARATE CELLULOSE, MICROCRYSTALLINE STEARIC ACID ASPARTAME SODIUM FLUORIDE FLUORIDE ION VITAMIN A VITAMIN A ASCORBIC ACID ASCORBIC ACID SODIUM ASCORBATE ASCORBIC ACID CHOLECALCIFEROL CHOLECALCIFEROL .ALPHA.-TOCOPHEROL ACETATE, DL- .ALPHA.-TOCOPHEROL, DL- THIAMINE MONONITRATE THIAMINE ION THIAMINE RIBOFLAVIN RIBOFLAVIN NIACINAMIDE NIACINAMIDE PYRIDOXINE HYDROCHLORIDE PYRIDOXINE FOLIC ACID FOLIC ACID CYANOCOBALAMIN CYANOCOBALAMIN Grape flavor Dark purple"],"package_label_principal_display_panel":["Flotrex™ Multivitamin Chewable plus 0.5 mg Fluoride Tablets Manufactured in the USA by: PureTek Corporation Panorama City, CA 91402 Questions? Call toll-free: 1-877-921-7873 Label"]},"tags":[],"safety":{"boxedWarnings":[],"commonSideEffects":[{"effect":"Allergic sensitization","drugRate":"","severity":"common","organSystem":""},{"effect":"Allergic reactions","drugRate":"","severity":"common","organSystem":""},{"effect":"Idiosyncratic reactions","drugRate":"","severity":"common","organSystem":""}],"contraindications":["This product is contraindicated in patients with a known hypersensitivity to any of the ingredients."],"seriousAdverseEvents":[]},"trials":[],"_chembl":null,"aliases":[],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=multivitamins","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T02:18:40.127597+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T02:18:45.907957+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=multivitamins","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T02:18:46.254954+00:00"},"mechanism.drugClass":{"url":"https://api.fda.gov/drug/label.json","method":"deterministic","source":"FDA Label (EPC)","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T02:18:38.939519+00:00"},"administration.route":{"url":"","method":"deterministic","source":"FDA Label","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T02:18:38.939550+00:00"},"indications.approved":{"url":"","method":"ai_extraction","source":"FDA Label + AI","aiModel":"featherless","rawText":"","confidence":0.9,"sourceType":"fda_label","retrievedAt":"2026-04-20T02:19:07.888374+00:00"},"safety.boxedWarnings":{"url":"","method":"deterministic","source":"FDA Label (no boxed warning)","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T02:18:38.939555+00:00"},"safety.commonSideEffects":{"url":"","method":"ai_extraction","source":"FDA Label + AI","aiModel":"featherless","rawText":"ADVERSE REACTIONS Folate: Allergic sensitization has been reported following both oral and parenteral administration of folate. Adverse reactions have been reported with specific vitamins and minerals but generally at levels substantially higher than those contained herein. However, allergic and idiosyncratic reactions are possible at lower levels.","confidence":0.95,"sourceType":"fda_label","retrievedAt":"2026-04-20T02:18:51.346875+00:00"},"safety.contraindications":{"url":"","method":"ai_extraction","source":"FDA Label + AI","aiModel":"featherless","rawText":"","confidence":0.95,"sourceType":"fda_label","retrievedAt":"2026-04-20T02:18:53.888262+00:00"}},"offLabel":[],"timeline":[],"_dailymed":{"setId":"30186998-2121-3ef2-e063-6394a90a513e","title":"FLOTREX (MULTIVITAMINS, SODIUM FLUORIDE 0.25 MG) TABLET, CHEWABLE [PURETEK CORPORATION]"},"ecosystem":[],"mechanism":{"drugClass":"Vitamin C [EPC]"},"_scrapedAt":"2026-03-28T01:22:28.263Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"references":[],"_validation":{"fieldsValidated":2,"lastValidatedAt":"2026-04-20T02:19:08.028431+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[],"indications":{"approved":[{"id":"multivitamins-vitamin-and-fluoride-deficienc","name":"Vitamin and Fluoride Deficiencies","dosing":null,"approvals":[],"diseaseId":"","eligibility":"Patients at high risk for dental caries and inadequate dietary intake of essential vitamins","pivotalTrial":null,"restrictions":[],"patientPopulation":"Patients at high risk for dental caries and inadequate dietary intake of essential vitamins","diagnosticRequired":null,"brandNameForIndication":""},{"id":"multivitamins-support-normal-growth-and-deve","name":"Support Normal Growth and Development","dosing":null,"approvals":[],"diseaseId":"","eligibility":"Not specified","pivotalTrial":null,"restrictions":[],"patientPopulation":"Not specified","diagnosticRequired":null,"brandNameForIndication":""},{"id":"multivitamins-promote-bone-and-dental-health","name":"Promote Bone and Dental Health","dosing":null,"approvals":[],"diseaseId":"","eligibility":"Not specified","pivotalTrial":null,"restrictions":[],"patientPopulation":"Not specified","diagnosticRequired":null,"brandNameForIndication":""},{"id":"multivitamins-maintain-metabolic-and-immune-","name":"Maintain Metabolic and Immune Function","dosing":null,"approvals":[],"diseaseId":"","eligibility":"Not specified","pivotalTrial":null,"restrictions":[],"patientPopulation":"Not specified","diagnosticRequired":null,"brandNameForIndication":""}]},"labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT07268326","phase":"NA","title":"Plant-Based Diet for Patients With Rheumatoid Arthritis","status":"RECRUITING","sponsor":"Center for Clinical Research and Prevention","startDate":"2025-12-15","conditions":"Rheumatoid Arthritis (RA)","enrollment":180},{"nctId":"NCT04874688","phase":"NA","title":"Child Health, Agriculture and Integrated Nutrition","status":"COMPLETED","sponsor":"Queen Mary University of London","startDate":"2021-04-26","conditions":"Stunting","enrollment":192},{"nctId":"NCT01954498","phase":"NA","title":"Effect of Walnuts on Sperm Parameters and Male Fertility","status":"COMPLETED","sponsor":"University of California, Los Angeles","startDate":"2014-05","conditions":"Oligozoospermia, Asthenozoospermia, Teratozoospermia","enrollment":80},{"nctId":"NCT07145658","phase":"NA","title":"Multivitamin for Health and Cognition","status":"COMPLETED","sponsor":"Dr Anthony Hobson","startDate":"2025-07-07","conditions":"Healthy, Cognition, Health","enrollment":37},{"nctId":"NCT06162715","phase":"PHASE2, PHASE3","title":"GLP-1 Receptor Agonists Post-Bariatric Surgery (GRABS) Pilot Trial","status":"ENROLLING_BY_INVITATION","sponsor":"Vanderbilt University Medical Center","startDate":"2024-10-30","conditions":"Severe Obesity, Obesity, BMI Greater Than 30","enrollment":30},{"nctId":"NCT07451496","phase":"NA","title":"PRecision gerOMedicinE: Tailored Healthy agEing With Lifestyle, sUpplements and drugS (PROMETHEUS)","status":"RECRUITING","sponsor":"National University of Singapore","startDate":"2025-09-29","conditions":"Ageing","enrollment":20},{"nctId":"NCT03630991","phase":"PHASE1","title":"Edetate Calcium Disodium or Succimer in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome Undergoing Chemotherapy","status":"RECRUITING","sponsor":"M.D. Anderson Cancer Center","startDate":"2018-10-11","conditions":"Acute Myeloid Leukemia, Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome, Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive","enrollment":58},{"nctId":"NCT07442162","phase":"PHASE1, PHASE2","title":"Effects of Melatonin on Excessive Crying in Neonates. A Randomized Controlled Clinical Trial.","status":"ENROLLING_BY_INVITATION","sponsor":"Al-Hadba university","startDate":"2026-02-23","conditions":"Crying","enrollment":165},{"nctId":"NCT07433049","phase":"NA","title":"Impact of Supplementation in Improving Metabolic Health Outcomes (ISMOS) Study","status":"RECRUITING","sponsor":"Institute for Human Development and Potential (IHDP), Singapore","startDate":"2026-01-20","conditions":"Glucose Control, Mental Health, Musculoskeletal Health","enrollment":400},{"nctId":"NCT00148629","phase":"PHASE3","title":"Treatment and Prevention of Severe Anemia in Pregnant Zanzibari Women","status":"COMPLETED","sponsor":"Cornell University","startDate":"2004-04","conditions":"Anemia, Low Birth Weight, Neonatal Mortality","enrollment":2500},{"nctId":"NCT07397572","phase":"","title":"Iron Supplementation and Anemia After Sleeve Gastrectomy","status":"RECRUITING","sponsor":"Cairo University","startDate":"2026-01-17","conditions":"Iron Deficiency Anemia, Obesity, Sleeve Gastrectomy","enrollment":66},{"nctId":"NCT07109505","phase":"NA","title":"Nutrition to Support Postoperative Recovery","status":"RECRUITING","sponsor":"Dartmouth-Hitchcock Medical Center","startDate":"2025-12-10","conditions":"Postoperative Care, Postoperative Complications, Cognition","enrollment":100},{"nctId":"NCT07368686","phase":"PHASE4","title":"Topical Multivitamin Serum for Skin Heath","status":"RECRUITING","sponsor":"Erevna Innovations Inc.","startDate":"2026-02-01","conditions":"Aesthetic","enrollment":30},{"nctId":"NCT07210190","phase":"PHASE4","title":"Microneedling for Skin Heath","status":"RECRUITING","sponsor":"Erevna Innovations Inc.","startDate":"2026-01-17","conditions":"Aesthetic","enrollment":30},{"nctId":"NCT07383974","phase":"NA","title":"The Impact of 12 Week Retention of Nutrients on Skin and the Perception of Physical Health Status","status":"RECRUITING","sponsor":"ChinaNorm","startDate":"2025-11-03","conditions":"Healthy Volunteers, Dietary Supplementation, Skin Health","enrollment":120},{"nctId":"NCT05232669","phase":"NA","title":"COcoa Supplement and Multivitamin Outcomes Study: Effects on Falls and Physical Performance","status":"ACTIVE_NOT_RECRUITING","sponsor":"Brigham and Women's Hospital","startDate":"2021-05-15","conditions":"Fall, Physical Performance, Fracture","enrollment":21442},{"nctId":"NCT05426525","phase":"PHASE4","title":"Use of Empagliflozin to Treat Prediabetes","status":"ACTIVE_NOT_RECRUITING","sponsor":"Oregon State University","startDate":"2022-10-13","conditions":"PreDiabetes, Prediabetic State, Overweight and Obesity","enrollment":60},{"nctId":"NCT05753215","phase":"PHASE2","title":"Controlled Trial of Omadacycline Randomized Treatment Given for Bone and Joint Infection","status":"ACTIVE_NOT_RECRUITING","sponsor":"Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center","startDate":"2023-05-09","conditions":"Bone Infection, Joint Infection, Bone and Joint Infection","enrollment":180},{"nctId":"NCT07341217","phase":"NA","title":"Chemo Brain Prehab Project","status":"NOT_YET_RECRUITING","sponsor":"Dr. Chris Gaffney","startDate":"2026-01-30","conditions":"Colorectal Cancer, Older Adults (60 - 85 Years Old), Physically Inactive","enrollment":86},{"nctId":"NCT03598842","phase":"NA","title":"Tuberculosis - Learning the Impact of Nutrition","status":"COMPLETED","sponsor":"Boston Medical Center","startDate":"2019-07-12","conditions":"Tuberculosis, Malnutrition, Helminth Infection","enrollment":786},{"nctId":"NCT05736562","phase":"NA","title":"Use of Ritual Epost Postnatal Multivitamins During the Postpartum Period","status":"ACTIVE_NOT_RECRUITING","sponsor":"City University of New York","startDate":"2023-10-15","conditions":"Lactation Disorder - Postpartum Condition or Complication, Nutrition, Healthy","enrollment":70},{"nctId":"NCT06816524","phase":"NA","title":"The Effects of Iron Treatment on Malaria and Measles Vaccine Response in Kenyan Infants With Iron Deficiency","status":"NOT_YET_RECRUITING","sponsor":"Nicole Stoffel","startDate":"2026-01-05","conditions":"Iron Deficiencies","enrollment":324},{"nctId":"NCT07303595","phase":"NA","title":"Mom Multi Postnatal Supplementation Trial","status":"RECRUITING","sponsor":"Perelel Inc.","startDate":"2025-11-10","conditions":"Postnatal Care","enrollment":80},{"nctId":"NCT07226414","phase":"NA","title":"Prenatal Study in Healthy Pregnant Women","status":"RECRUITING","sponsor":"Perelel Inc.","startDate":"2025-12-01","conditions":"Pregnancy","enrollment":40},{"nctId":"NCT03860792","phase":"NA","title":"Therapeutic Diets in Alzheimer's Disease","status":"COMPLETED","sponsor":"University of Kansas Medical Center","startDate":"2019-10-15","conditions":"Alzheimer Disease","enrollment":84},{"nctId":"NCT07289867","phase":"NA","title":"Nutritional Effects of Supplementing Nonagenarians With a Supplement Based on a Fruit From the Cerrado: Buriti","status":"COMPLETED","sponsor":"Federal University of Minas Gerais","startDate":"2024-05-01","conditions":"Malnutrition in the Elderly","enrollment":40},{"nctId":"NCT07270640","phase":"NA","title":"Lifestyle Intervention to Improve Twin Pregnancy Outcomes","status":"RECRUITING","sponsor":"Universitaire Ziekenhuizen KU Leuven","startDate":"2025-12-05","conditions":"Twin Pregnancy, Dichorionic","enrollment":81},{"nctId":"NCT03991897","phase":"NA","title":"Nutritional Ketosis: a Novel Metabolic Strategy to Treat Lymphedema Patients?","status":"RECRUITING","sponsor":"Universitaire Ziekenhuizen KU Leuven","startDate":"2025-10-01","conditions":"Lymphedema, Ketogenic Dieting, Ketone Ester Supplement","enrollment":81},{"nctId":"NCT02950259","phase":"PHASE1","title":"Pre-operative IRX-2 in Early Stage Breast Cancer (ESBC)","status":"COMPLETED","sponsor":"Providence Health & Services","startDate":"2017-02-09","conditions":"Breast Neoplasm, Breast Neoplasm, Male, Triple Negative Breast Cancer","enrollment":16},{"nctId":"NCT06565052","phase":"NA","title":"The Impact of PReOPerative Exercise and NutritionaL Optimization on Perioperative Outcomes for Patients Undergoing Treatment for Rectal Cancer: The PROPEL Trial","status":"RECRUITING","sponsor":"Dana-Farber Cancer Institute","startDate":"2024-12-15","conditions":"Rectal Cancer, Colorectal Cancer, Rectal Cancer Stage II","enrollment":40},{"nctId":"NCT07242430","phase":"NA","title":"12-week Multi-vitamin/Mineral Supplementation on Peri-menopause Symptoms, Cognition, Sleep, and Psychological Well-being.","status":"NOT_YET_RECRUITING","sponsor":"Northumbria University","startDate":"2025-11-20","conditions":"Perimenopause, Perimenopausal Women, Perimenopause, Climacteric Syndrome","enrollment":58},{"nctId":"NCT07234916","phase":"NA","title":"Multivitamin Impact on Micronutrient Status in GLP-1 Users: A Randomized Trial","status":"ENROLLING_BY_INVITATION","sponsor":"Erasmus Medical Center","startDate":"2025-12-16","conditions":"Weight Loss, Nutritional Deficiencies, GLP - 1","enrollment":246},{"nctId":"NCT07031973","phase":"PHASE3","title":"The Effect of Micronutrient Supplementation on Nutrition Status and Well-being","status":"COMPLETED","sponsor":"InnoNext Sarl","startDate":"2025-02-18","conditions":"Micronutrient Deficiencies","enrollment":150},{"nctId":"NCT06811233","phase":"PHASE2","title":"Monitoring, Detoxifying, and Rebalancing Metals During Acute Myeloid Leukemia (AML) Therapy, a Phase 2 Randomized Study","status":"RECRUITING","sponsor":"M.D. Anderson Cancer Center","startDate":"2025-05-08","conditions":"Acute Myeloid Leukemia (AML)","enrollment":140},{"nctId":"NCT05971173","phase":"EARLY_PHASE1","title":"Nutritional Optimization and Bone Health Management for Older Adults Undergoing Hip Fracture Surgery","status":"COMPLETED","sponsor":"The University of Texas Health Science Center at San Antonio","startDate":"2023-09-28","conditions":"Hip Fractures","enrollment":40},{"nctId":"NCT07204379","phase":"EARLY_PHASE1","title":"Effect of Oral Analgesics on Post-op Pain","status":"COMPLETED","sponsor":"Armed Forces Institute of Dentistry, Pakistan","startDate":"2023-01-01","conditions":"Post Operative Pain","enrollment":100},{"nctId":"NCT02422745","phase":"PHASE4","title":"COcoa Supplement and Multivitamin Outcomes Study","status":"COMPLETED","sponsor":"Brigham and Women's Hospital","startDate":"2015-06","conditions":"Cardiovascular Disease, Cancer","enrollment":21442},{"nctId":"NCT05067998","phase":"","title":"The Benefits of Natural Medicine, Vitamin IV Therapy and Supplements: Maintaining Good Health Through Nature","status":"RECRUITING","sponsor":"Faith A. Richardson","startDate":"2025-12-21","conditions":"Anxiety Disorders and Symptoms, Fibromyalgia, Arthritis","enrollment":25},{"nctId":"NCT06981936","phase":"PHASE4","title":"This Randomized Trial Aims to Investigate the Efficacy of Balanced Nutritional Tablets-Comprehensive Multivitamin and Mineral Supplements- in Preventing Micronutrient Deficiencies Among Patients Utilizing GLP-1 RAs for Weight Loss in Comparison to a Placebo Control","status":"RECRUITING","sponsor":"General Committee of Teaching Hospitals and Institutes, Egypt","startDate":"2025-05-15","conditions":"Micronutrient Deficiencies","enrollment":150},{"nctId":"NCT07021170","phase":"PHASE4","title":"Trial Comparing Elan Specialized Bariatric Supplements With Standard Multivitamins in Patients Undergoing Bariatric Procedures","status":"RECRUITING","sponsor":"General Committee of Teaching Hospitals and Institutes, Egypt","startDate":"2025-06-15","conditions":"Vitamin Deficiencies","enrollment":624},{"nctId":"NCT05036603","phase":"NA","title":"Comparison of the Acute Effects of Chest Physiotherapy Methods Applied in Different Positions in Preterm Newborns","status":"COMPLETED","sponsor":"Sanko University","startDate":"2022-04-01","conditions":"Preterm Birth, Premature, Bronchopulmonary Dysplasia","enrollment":60},{"nctId":"NCT07160426","phase":"PHASE2","title":"Study of Protection And Repair of Endothelial-glycocalyx in Sepsis","status":"NOT_YET_RECRUITING","sponsor":"Beth Israel Deaconess Medical Center","startDate":"2025-11-01","conditions":"Sepsis","enrollment":45},{"nctId":"NCT07100587","phase":"NA","title":"Ketogenic vs. Mediterranean Diet on Metabolic and Hormonal Parameters in Patients With Active Acromegaly","status":"COMPLETED","sponsor":"University of Palermo","startDate":"2024-06-30","conditions":"Acromegaly","enrollment":26},{"nctId":"NCT03859687","phase":"PHASE1","title":"Trial of Antibody Responses by Vitamin Supplementation","status":"TERMINATED","sponsor":"St. Jude Children's Research Hospital","startDate":"2019-08-19","conditions":"Healthy Participants","enrollment":22},{"nctId":"NCT05062044","phase":"","title":"A Study to Gather Information About the Progress and Outcomes of Pregnancy in Women Using Various Vitamin Support Plans Before and During Pregnancy","status":"COMPLETED","sponsor":"Bayer","startDate":"2021-12-01","conditions":"Prevention of Vitamin Deficiency During and/or Before Pregnancy","enrollment":1500},{"nctId":"NCT06759350","phase":"NA","title":"Soy Isoflavonates Versus Placebo on Quality of Life in Menopausal Women","status":"COMPLETED","sponsor":"Universidad Nacional Autonoma de Honduras","startDate":"2025-02-01","conditions":"Menopause, Menopausal Women, Soy Isoflavone Effect","enrollment":100},{"nctId":"NCT07146321","phase":"NA","title":"A Study to Investigate the Effect of a Multivitamin, Multi-nutrient Supplement on Mental and Emotional Wellbeing","status":"NOT_YET_RECRUITING","sponsor":"Biologica Inc","startDate":"2025-09-01","conditions":"Menopause","enrollment":80},{"nctId":"NCT02378246","phase":"NA","title":"Swedish Iodine in Pregnancy and Development in Children (SWIDDICH) Study","status":"ACTIVE_NOT_RECRUITING","sponsor":"Göteborg University","startDate":"2012-11","conditions":"Thyroid Gland; Node, Pregnancy, Cognitive Developmental Delay","enrollment":1337},{"nctId":"NCT07138391","phase":"PHASE2, PHASE3","title":"Chamomile Gummies and Pediatric Dental Anxiety","status":"NOT_YET_RECRUITING","sponsor":"Ain Shams University","startDate":"2025-08","conditions":"Dental Anxiety","enrollment":78},{"nctId":"NCT07135245","phase":"PHASE2","title":"Improved Treatment and Monitoring of Alzheimer's Disease","status":"NOT_YET_RECRUITING","sponsor":"Rune Skovgaard Rasmussen","startDate":"2026-01-01","conditions":"Alzheimer Disease (AD)","enrollment":180},{"nctId":"NCT04485611","phase":"NA","title":"Prehabilitation of Veterans With Exercise and Nutrition","status":"COMPLETED","sponsor":"VA Office of Research and Development","startDate":"2021-05-27","conditions":"Frailty","enrollment":20},{"nctId":"NCT07130396","phase":"NA","title":"Impact of Multivitamin (PhytoMulti®) and a Probiotic (UltraFlora® Balance Probiotic) on Gut Health of People Taking GLP-1 Medication","status":"NOT_YET_RECRUITING","sponsor":"Metagenics, Inc.","startDate":"2025-11-01","conditions":"GLP-1, Adults","enrollment":100},{"nctId":"NCT05473039","phase":"NA","title":"Effect of a Multivitamin Supplement With Probiotic (Seidivid Ferty4®) on Oocyte Retrieval and Quality","status":"COMPLETED","sponsor":"SEID S.A.","startDate":"2022-07-11","conditions":"Reproductive Techniques, Assisted","enrollment":196},{"nctId":"NCT07121127","phase":"EARLY_PHASE1","title":"Effect of Fu's Subcutaneous Needling for Age-related Macular Degeneration","status":"NOT_YET_RECRUITING","sponsor":"Zhiming Yan","startDate":"2026-07-07","conditions":"Age - Related Macular Degeneration (AMD)","enrollment":38},{"nctId":"NCT05673070","phase":"NA","title":"Use of Ritual Prenatal Multivitamins for Pregnancy","status":"COMPLETED","sponsor":"City University of New York","startDate":"2023-10-15","conditions":"Pregnancy Related, Nutrition, Healthy","enrollment":62},{"nctId":"NCT04112732","phase":"NA","title":"Improving Everyday Functioning in Adults Aged 70 and Over Using a Multivitamin Supplement","status":"COMPLETED","sponsor":"Northumbria University","startDate":"2019-11-24","conditions":"Aging, Stress","enrollment":228},{"nctId":"NCT07087561","phase":"NA","title":"Short-Term Nutritional Enhancement Combined With Health Education in Postoperative Colorectal Cancer Patients: A Randomized Controlled Trial","status":"RECRUITING","sponsor":"Xiaoqin Luo","startDate":"2024-10-10","conditions":"Colorectal Cancer (Diagnosis), Malnutrition or Risk of Malnutrition","enrollment":360},{"nctId":"NCT03472664","phase":"NA","title":"Brain Energy for Amyloid Transformation in Alzheimer's Disease Study","status":"RECRUITING","sponsor":"Wake Forest University Health Sciences","startDate":"2018-07-16","conditions":"Alzheimer Disease, Mild Cognitive Impairment","enrollment":120},{"nctId":"NCT01047735","phase":"NA","title":"The TRIABETES - ARMMS-T2D Study: A Randomized Trial to Compare Surgical and Medical Treatments for Type 2 Diabetes","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Pittsburgh","startDate":"2009-09-01","conditions":"Type 2 Diabetes Mellitus, Obesity","enrollment":69},{"nctId":"NCT06630637","phase":"NA","title":"Monitoring Intermittent Fasting for Human Optimization Using Wearable Technology: An N-of-1 Study","status":"COMPLETED","sponsor":"Institute for Digital Medicine (WisDM)","startDate":"2024-10-07","conditions":"Intermittent Fasting, Healthy, Digital Health","enrollment":1},{"nctId":"NCT07000201","phase":"NA","title":"Preoperative Pregabalin vs Gabapentin in Elderly Undergoing Surgry,Controlled Trial","status":"NOT_YET_RECRUITING","sponsor":"Cairo University","startDate":"2025-09-15","conditions":"Anxiety, Anxiety Disorder (Panic Disorder or GAD)","enrollment":84},{"nctId":"NCT04730869","phase":"NA","title":"Metabolic Therapy Program In Conjunction With Standard Treatment For Glioblastoma","status":"ACTIVE_NOT_RECRUITING","sponsor":"Waikato Hospital","startDate":"2021-05-26","conditions":"Glioblastoma","enrollment":18},{"nctId":"NCT03004807","phase":"NA","title":"Role of Centrum® Silver® in Improving Micronutrient Status in Older Men","status":"COMPLETED","sponsor":"Oregon State University","startDate":"2018-07-01","conditions":"Vitamin Deficiency, Mineral Deficiency, Aging","enrollment":41},{"nctId":"NCT06505408","phase":"NA","title":"Impact of a MVM to Support Biomarkers Associated With Conception and Pregnancy in Healthy Women.","status":"COMPLETED","sponsor":"Perelel Inc.","startDate":"2024-10-02","conditions":"Healthy Adult Women of Child Bearing Age","enrollment":60},{"nctId":"NCT01419730","phase":"PHASE2","title":"Vitamin D and Physical Activity on Bone Health","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Rochester","startDate":"2011-08","conditions":"Bone Metabolism Biomarkers, Bone Mineral Density, Physical Fitness","enrollment":191},{"nctId":"NCT05912257","phase":"NA","title":"Preserving Physical Function in Older Adults With Cancer: Impact of an Optimizing Nutrition Intervention Applied Before and After Surgery","status":"RECRUITING","sponsor":"VA Office of Research and Development","startDate":"2024-05-01","conditions":"Cancer","enrollment":188},{"nctId":"NCT02397200","phase":"NA","title":"Evaluating the Effect of Nutritional Supplementation on Growth of Short and Lean Adolescents Girls","status":"COMPLETED","sponsor":"Rabin Medical Center","startDate":"2015-06","conditions":"Growth Problem, Low Weight","enrollment":99},{"nctId":"NCT06169826","phase":"PHASE4","title":"Histidine Oral Supplementation as a Therapeutic Modality for Alzheimer's Disease","status":"WITHDRAWN","sponsor":"Wake Forest University Health Sciences","startDate":"2025-04","conditions":"Alzheimer Disease","enrollment":""},{"nctId":"NCT05899166","phase":"NA","title":"Carbohydrate Beta Cell Function and Glucose Control in Children With Diabetes","status":"RECRUITING","sponsor":"Boston Children's Hospital","startDate":"2024-05-31","conditions":"Diabetes Mellitus, Type 1","enrollment":52},{"nctId":"NCT03835325","phase":"NA","title":"The Effect of a Multivitamin in the Treatment of Memory Loss in Postmenopausal Women","status":"COMPLETED","sponsor":"Eurofarma Laboratorios S.A.","startDate":"2019-01-23","conditions":"Memory Disorders, Postmenopausal Symptoms","enrollment":80},{"nctId":"NCT03267680","phase":"PHASE2","title":"IRX-2 Regimen in Treating Women With Cervical Squamous Intraepithelial Neoplasia 3 or Squamous Vulvar Intraepithelial Neoplasia 3","status":"TERMINATED","sponsor":"University of Southern California","startDate":"2017-11-08","conditions":"Cervical Squamous Cell Carcinoma In Situ, Vulvar High Grade Squamous Intraepithelial Lesion","enrollment":10},{"nctId":"NCT06906172","phase":"NA","title":"The REmission of Diabetes Using a PlAnt-based Weight Loss InteRvention (REPAIR) Trial","status":"NOT_YET_RECRUITING","sponsor":"University of Toronto","startDate":"2025-09","conditions":"Diabetes Mellitus","enrollment":160},{"nctId":"NCT02733185","phase":"PHASE3","title":"Trial to Assess Chelation Therapy 2","status":"COMPLETED","sponsor":"Mt. Sinai Medical Center, Miami","startDate":"2016-10-01","conditions":"Diabetes, Myocardial Infarction","enrollment":1000},{"nctId":"NCT06100432","phase":"PHASE4","title":"Effect of Eurycoma Longifolia (DLBS5055) and Multivitamins (Vitamin C+Vitamin E+ Β-carotene) for Infertile Males","status":"ACTIVE_NOT_RECRUITING","sponsor":"Duta Wacana Christian University","startDate":"2023-11-11","conditions":"Male Infertility","enrollment":90},{"nctId":"NCT06890221","phase":"NA","title":"Impact of PErioperative Nutrition Intervention on Bioimpedance Phase Angle (IPENIPA) In Breast Cancer Patients","status":"RECRUITING","sponsor":"University of Malaya","startDate":"2025-03-07","conditions":"Breast Cancer Early Stage Breast Cancer (Stage 1-3), Mastectomy Patient","enrollment":114},{"nctId":"NCT06560879","phase":"PHASE2","title":"Effectiveness of Probiotics for the Prevention of Gastrointestinal Toxicity in Children with Leukemia","status":"ENROLLING_BY_INVITATION","sponsor":"National Institute of Pediatrics, Mexico","startDate":"2025-02-01","conditions":"Probiotics, Gastrointestinal Diseases, Precursor Cell Lymphoblastic Leukemia-Lymphoma","enrollment":120},{"nctId":"NCT00920621","phase":"PHASE3","title":"Randomized Trial: Maternal Vitamin D Supplementation to Prevent Childhood Asthma (VDAART)","status":"COMPLETED","sponsor":"Brigham and Women's Hospital","startDate":"2009-09","conditions":"Asthma","enrollment":876},{"nctId":"NCT04570475","phase":"NA","title":"High Dose Vitamin D Plus Multivitamin in the Prevention of Cluster Headache","status":"TERMINATED","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2021-09-15","conditions":"Cluster Headache","enrollment":27},{"nctId":"NCT01785719","phase":"NA","title":"Evaluation of Ovarian Morphology and Function in Overweight Women During Weight Loss","status":"COMPLETED","sponsor":"Cornell University","startDate":"2013-01","conditions":"Weight Loss, Anovulation, Amenorrhea","enrollment":79},{"nctId":"NCT06795789","phase":"NA","title":"Multivitamin Intervention and Cognitive Function","status":"NOT_YET_RECRUITING","sponsor":"Braincare Limited","startDate":"2025-03-01","conditions":"Healthy Adult, Cognitive Measures","enrollment":30},{"nctId":"NCT06758323","phase":"NA","title":"Acute Effects of Beetroot Juice and Caffeine Co-ingestion on Lower-limb Strength and Muscular Endurance in Females","status":"COMPLETED","sponsor":"Jose Manuel Jurado Castro","startDate":"2024-08-01","conditions":"Beetroot Juice, Caffeine, Placebo","enrollment":15},{"nctId":"NCT04219709","phase":"NA","title":"Effects of Ketosis on Brain Function in Patients With T1DM","status":"RECRUITING","sponsor":"Boston Children's Hospital","startDate":"2020-01-03","conditions":"Type1diabetes","enrollment":24},{"nctId":"NCT04200391","phase":"NA","title":"Very Low Carbohydrate Diets and Glucagon Response in T1DM","status":"RECRUITING","sponsor":"Boston Children's Hospital","startDate":"2020-01-03","conditions":"Type1diabetes","enrollment":12},{"nctId":"NCT03710928","phase":"NA","title":"Type 1 Diabetes Management Using a Very Low Carbohydrate Versus Standard Diet","status":"RECRUITING","sponsor":"Boston Children's Hospital","startDate":"2020-01-03","conditions":"Type1diabetes","enrollment":32},{"nctId":"NCT06425796","phase":"NA","title":"Adiposity and Iron Requirements in Pregnancy","status":"RECRUITING","sponsor":"University of Ulster","startDate":"2024-05-20","conditions":"Iron Deficiency Anemia of Pregnancy","enrollment":312},{"nctId":"NCT03410823","phase":"NA","title":"PUSH Plus Protein Pilot for Hip Fracture Patients","status":"TERMINATED","sponsor":"University of Maryland, Baltimore","startDate":"2018-07-16","conditions":"Hip Fracture","enrollment":20},{"nctId":"NCT03515889","phase":"NA","title":"A Trial of the Ideal Protein System Versus Low Fat Diet for Weight Loss","status":"COMPLETED","sponsor":"Tulane University","startDate":"2018-05-23","conditions":"Weight Loss","enrollment":192},{"nctId":"NCT05371288","phase":"EARLY_PHASE1","title":"The Role of Glutathione Deficiency and MSIDS Variables in Long COVID-19","status":"WITHDRAWN","sponsor":"University of California, Irvine","startDate":"2025-06","conditions":"COVID-19","enrollment":""},{"nctId":"NCT06666660","phase":"NA","title":"Daily Intake of Multivitamin & Mineral Supplementation Effects on Biological Age of Relatively Healthy Middle-aged Individuals","status":"RECRUITING","sponsor":"National University of Singapore","startDate":"2024-09-23","conditions":"Relatively Healthy Volunteers","enrollment":400},{"nctId":"NCT06568146","phase":"NA","title":"A Single Group Study to Evaluate the Effects of a Multivitamin on a Range of Health and Wellbeing Outcomes.","status":"COMPLETED","sponsor":"Love Wellness","startDate":"2024-05-23","conditions":"Health and Wellbeing","enrollment":40},{"nctId":"NCT06659380","phase":"NA","title":"Probiotic Efficacy in Postmenopausal Women with Bacterial Vaginosis","status":"RECRUITING","sponsor":"Hasanuddin University","startDate":"2024-06-26","conditions":"Bacterial Vaginosis (BV), Menopause","enrollment":12},{"nctId":"NCT06484881","phase":"PHASE3","title":"Clinical Study of Probiotic Treatment for Androgenetic Alopecia","status":"WITHDRAWN","sponsor":"Applied Biology, Inc.","startDate":"2024-09-15","conditions":"Androgenetic Alopecia, Female Pattern Baldness","enrollment":""},{"nctId":"NCT05556356","phase":"PHASE4","title":"Effect of Perioperative Acetaminophen Dosing on Patients Undergoing Surgical Treatment of Basilar Thumb Arthritis","status":"TERMINATED","sponsor":"Indiana Hand to Shoulder Center","startDate":"2022-09-13","conditions":"Carpometacarpal Osteoarthritis","enrollment":23},{"nctId":"NCT06621680","phase":"NA","title":"Effect of Connective Tissue Massage on Premenstrual Syndrome","status":"NOT_YET_RECRUITING","sponsor":"Cairo University","startDate":"2024-10-10","conditions":"Premenstrual Syndrome","enrollment":50},{"nctId":"NCT03146273","phase":"NA","title":"Study of Absorption Characteristics of Two Multivitamin Mineral Formulations (Gel vs. Tablet/Capsule)","status":"COMPLETED","sponsor":"Galilee CBR","startDate":"2017-05-09","conditions":"Vitamin Deficiency","enrollment":20},{"nctId":"NCT06219525","phase":"NA","title":"Higher and Standard Doses of Enteral Zinc Supplementation in Very Preterm Infants","status":"RECRUITING","sponsor":"Prince of Songkla University","startDate":"2024-04-02","conditions":"Very Preterm Infants, Zinc Deficiency","enrollment":120},{"nctId":"NCT06574685","phase":"NA","title":"Efficacy of Twinkle Eyez Supplementation in Improving Ocular Health and Immunity","status":"COMPLETED","sponsor":"Ecolite Group","startDate":"2024-07-01","conditions":"Dry Eye Disease, Immunity","enrollment":110},{"nctId":"NCT06553963","phase":"NA","title":"Athlete Biochemical Monitoring and Nutritional Support","status":"NOT_YET_RECRUITING","sponsor":"Chengdu Sport University","startDate":"2024-08-20","conditions":"Weight Reduction","enrollment":28},{"nctId":"NCT04841265","phase":"NA","title":"The Effect of Vitamin D Supplementation in Overweight and Obese Pregnant Women","status":"COMPLETED","sponsor":"KK Women's and Children's Hospital","startDate":"2021-05-28","conditions":"Overweight and Obesity","enrollment":274},{"nctId":"NCT06484634","phase":"NA","title":"Role of Low-Molecular-Weight Heparin in Unexplained Recurrent Pregnancy Loss","status":"COMPLETED","sponsor":"RESnTEC, Institute of Research","startDate":"2023-12-01","conditions":"Pregnancy Loss","enrollment":175}],"_emaApprovals":[],"_faersSignals":[{"count":2727,"reaction":"FATIGUE"},{"count":2130,"reaction":"DIARRHOEA"},{"count":2069,"reaction":"DRUG INEFFECTIVE"},{"count":2015,"reaction":"NAUSEA"},{"count":1661,"reaction":"HEADACHE"},{"count":1494,"reaction":"DIZZINESS"},{"count":1354,"reaction":"PAIN"},{"count":1242,"reaction":"DYSPNOEA"},{"count":1178,"reaction":"RASH"},{"count":1147,"reaction":"PNEUMONIA"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{"route":"Oral"},"formularyStatus":[],"_approvalHistory":[],"developmentCodes":[],"ownershipHistory":[],"publicationCount":2010,"therapeuticAreas":["Other"],"biosimilarFilings":[],"companionDiagnostics":[],"genericManufacturerList":[],"phase":"marketed","status":"active","brandName":"multivitamins","genericName":"multivitamins","companyName":"Faculdade de Medicina do ABC","companyId":"faculdade-de-medicina-do-abc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"","enrichmentLevel":3,"visitCount":1,"regulatoryByCountry":[{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":2,"withResults":0},"validation":{"fieldsValidated":2,"lastValidatedAt":"2026-04-20T02:19:08.028431+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"verified","dataCompleteness":{"mechanism":false,"indications":true,"safety":true,"trials":true,"score":3}}