{"id":"multimodal-acetaminophen-gabapentin-ketamine-bupivacaine","safety":{"commonSideEffects":[{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Sedation"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Local injection site reactions"}]},"_chembl":{"chemblId":"CHEMBL940","moleculeType":"Small molecule","molecularWeight":"171.24"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Acetaminophen inhibits prostaglandin synthesis; gabapentin modulates calcium channels and reduces neuronal excitability; ketamine antagonizes NMDA receptors to block pain signaling; and bupivacaine is a local anesthetic that blocks sodium channels. Together, these agents target pain through peripheral, spinal, and central mechanisms, allowing lower individual doses and potentially reducing adverse effects.","oneSentence":"This multimodal formulation combines four analgesic and anesthetic agents with distinct mechanisms to provide synergistic pain relief through multiple pathways.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:56:02.535Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute and chronic pain management"},{"name":"Postoperative pain"}]},"trialDetails":[{"nctId":"NCT01868425","phase":"PHASE4","title":"ACL Repair and Multimodal Analgesia","status":"COMPLETED","sponsor":"University of Wisconsin, Madison","startDate":"2013-04","conditions":"Pain","enrollment":112}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"multimodal:acetaminophen, gabapentin, ketamine, bupivacaine","genericName":"multimodal:acetaminophen, gabapentin, ketamine, bupivacaine","companyName":"University of Wisconsin, Madison","companyId":"university-of-wisconsin-madison","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This multimodal formulation combines four analgesic and anesthetic agents with distinct mechanisms to provide synergistic pain relief through multiple pathways. Used for Acute and chronic pain management, Postoperative pain.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}