{"id":"mta-pulp-dressing-material","safety":{"commonSideEffects":[{"rate":null,"effect":"Discoloration of tooth structure"},{"rate":null,"effect":"Difficulty in removal if needed"},{"rate":null,"effect":"Potential cytotoxicity if not properly set"}]},"_chembl":{"chemblId":"CHEMBL4877019","moleculeType":"Unknown","molecularWeight":"313.34"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"MTA is a cement-based endodontic material that sets in the presence of moisture and releases calcium hydroxide, creating an alkaline environment that stimulates odontoblast activity and promotes remineralization. It forms a tight seal and exhibits antimicrobial properties, making it suitable for pulp capping, apexification, and root perforation repair in dental applications.","oneSentence":"MTA (Mineral Trioxide Aggregate) pulp dressing material promotes biocompatibility and hard tissue formation through alkaline pH and calcium ion release at the dentin-pulp interface.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:56:00.199Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Direct and indirect pulp capping"},{"name":"Apexification in immature teeth"},{"name":"Root perforation repair"},{"name":"Retrograde filling in endodontic surgery"}]},"trialDetails":[{"nctId":"NCT06787742","phase":"PHASE3","title":"Assessment of the Number of Missing Tooth Surfaces and the Molecular Findings on the Outcomes of Vital Pulp Therapy Using Two Calcium Silicate Materials","status":"COMPLETED","sponsor":"Suez Canal University","startDate":"2022-09-21","conditions":"Vital Pulp Therapies, Tooth Defect","enrollment":60},{"nctId":"NCT06807320","phase":"PHASE4","title":"COMPARISON of MINERAL TRIOXIDE AGGREGATE and CALCIUM HYDROXIDE AS INDIRECT PULP CAPPING AGENTS in PRIMARY MOLARS","status":"COMPLETED","sponsor":"Shaheed Zulfiqar Ali Bhutto Medical University","startDate":"2022-01-01","conditions":"Indirect Pulp Cap","enrollment":40},{"nctId":"NCT06288477","phase":"NA","title":"Clinical and Radiographic Evaluation of Vital Pulpotomy Techniques in Primary Molars Using of Premixed Bioactive Bioceramic MTA (Neo-putty) as a Novel Pulpotomy Medication Versus Formocresol","status":"RECRUITING","sponsor":"October University for Modern Sciences and Arts","startDate":"2024-03-20","conditions":"Vital, Pulpotomy, Techniques","enrollment":44},{"nctId":"NCT06679075","phase":"PHASE2","title":"Clinical and Radiographic Evaluation of Propolis As a Hemostatic Agent for Pulpotomy of Mature Permanent Molars with Irreversible Pulpitis Using Two Different Dressing Materials","status":"ACTIVE_NOT_RECRUITING","sponsor":"Misr International University","startDate":"2024-11-01","conditions":"Irreversible Pulpitis, Pulpitis, Pulpitis - Irreversible","enrollment":60},{"nctId":"NCT06372561","phase":"NA","title":"Comparative Evaluation of Melatonin Versus MTA on Vital Pulp Therapy in Young Permanent First Molars: An in Vivo Study","status":"RECRUITING","sponsor":"Suez Canal University","startDate":"2023-05-20","conditions":"Dental Caries in Children, Vital Pulp Therapy","enrollment":45},{"nctId":"NCT04345263","phase":"NA","title":"Outcome of Full Pulpotomy Using Calcium Silicate Based Materials","status":"ACTIVE_NOT_RECRUITING","sponsor":"Jordan University of Science and Technology","startDate":"2017-09-01","conditions":"Carious Teeth","enrollment":150},{"nctId":"NCT04795830","phase":"PHASE4","title":"Bioactive Materials in Pulp Therapy of Primary Teeth","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2021-08-01","conditions":"Pulpitis, Pulp Disease, Dental","enrollment":60},{"nctId":"NCT05597553","phase":"NA","title":"Evaluation of Premixed Verses Powder/Liquid Bioceramic MTA in Indirect Pulp Capping.","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2023-01-01","conditions":"Indirect Pulp Capping","enrollment":24},{"nctId":"NCT04308863","phase":"PHASE2","title":"Evaluation of Chitosan Scaffold and Mineral Trioxide Aggregate Pulpotomy in Mature Permanent Molars With Irreversible Pulpitis","status":"COMPLETED","sponsor":"Nourhan M.Aly","startDate":"2018-11-15","conditions":"Pulpitis - Irreversible","enrollment":30},{"nctId":"NCT03522051","phase":"NA","title":"Assessment of Pulpotomy Procedure Using NeoMTA Plus in Permanent Teeth With Carious Exposure","status":"COMPLETED","sponsor":"Jordan University of Science and Technology","startDate":"2016-12-01","conditions":"Pulpotomy","enrollment":109},{"nctId":"NCT03833557","phase":"NA","title":"Success Rate of Three Capping Materials","status":"COMPLETED","sponsor":"Cairo University","startDate":"2017-05-05","conditions":"Caries","enrollment":54},{"nctId":"NCT04270318","phase":"NA","title":"Sodium Hypoclorite as an Antibacterial Agent Prior to Pulpotomies","status":"COMPLETED","sponsor":"Izmir Katip Celebi University","startDate":"2012-09","conditions":"Pulpotomy, Primary Teeth","enrollment":64},{"nctId":"NCT03735069","phase":"NA","title":"Vital Pulp Therapy in Carious Teeth With Hypomineralization","status":"COMPLETED","sponsor":"Jordan University of Science and Technology","startDate":"2017-09-12","conditions":"Dental Caries Extending to Pulp, Molar Incisor Hypomineralization","enrollment":62}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":10,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"MTA pulp dressing material","genericName":"MTA pulp dressing material","companyName":"Nourhan M.Aly","companyId":"nourhan-m-aly","modality":"Small molecule","firstApprovalDate":"","aiSummary":"MTA (Mineral Trioxide Aggregate) pulp dressing material promotes biocompatibility and hard tissue formation through alkaline pH and calcium ion release at the dentin-pulp interface. Used for Direct and indirect pulp capping, Apexification in immature teeth, Root perforation repair.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":2,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}