{"id":"mt-7117","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Hypotension"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The drug directly activates soluble guanylate cyclase, an enzyme that produces cyclic guanosine monophosphate (cGMP), a key signaling molecule in vascular smooth muscle relaxation. By increasing cGMP levels, MT-7117 promotes vasodilation and reduces pulmonary vascular resistance, making it suitable for treating pulmonary hypertension. This mechanism is independent of nitric oxide availability, potentially offering benefits in patients with impaired nitric oxide signaling.","oneSentence":"MT-7117 is a selective activator of the soluble guanylate cyclase (sGC) pathway that increases intracellular cGMP levels to promote vasodilation and reduce pulmonary vascular resistance.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:22:19.159Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Pulmonary arterial hypertension (PAH)"}]},"trialDetails":[{"nctId":"NCT03520036","phase":"PHASE2","title":"Study to Evaluate Efficacy, Safety, and Tolerability of MT-7117 in Subjects With Erythropoietic Protoporphyria","status":"COMPLETED","sponsor":"Tanabe Pharma America, Inc.","startDate":"2018-07-05","conditions":"Erythropoietic Protoporphyria (EPP)","enrollment":102},{"nctId":"NCT04402489","phase":"PHASE3","title":"Study to Evaluate Efficacy, Safety, and Tolerability of MT-7117 in Subjects With 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resistance. Used for Pulmonary arterial hypertension (PAH).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":5,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}