{"id":"mpnc-candidate","rwe":[],"tags":[],"safety":{"boxedWarnings":[],"drugInteractions":[{"drug":"Warfarin","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Aspirin","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Ibuprofen","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Pain medications","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Anticoagulants","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Antiplatelets","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Selective serotonin reuptake inhibitors (SSRIs)","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Serotonin-norepinephrine reuptake inhibitors (SNRIs)","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Tricyclic antidepressants","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Monoamine oxidase inhibitors (MAOIs)","action":"Monitor","effect":"Increased risk of 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efficacy of mPnC"},{"drug":"Daclatasvir","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Ledipasvir","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Sofosbuvir","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Voxilaprevir","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Peginterferon alfa-2a","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Peginterferon alfa-2b","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Peginterferon beta-1a","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Peginterferon beta-1b","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Rituximab","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Abatacept","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Alefacept","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Anakinra","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Etanercept","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Infliximab","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Tocilizumab","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Adalimumab","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Certolizumab pegol","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Golimumab","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Natalizumab","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Omalizumab","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Rilonacept","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Tofacitinib","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Upadacitinib","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Baricitinib","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Brodalumab","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Ixekizumab","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Secukinumab","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Tildrakizumab","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Ustekinumab","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Apremilast","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Brodalumab","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Iloprost","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Macitentan","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Riociguat","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Sildenafil","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Tadalafil","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Vardenafil","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Avanafil","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Bosentan","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Epoprostenol","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Fosinopril","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Lisinopril","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Quinapril","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Ramipril","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Trandolapril","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Valsartan","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Candesartan","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Eprosartan","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Irbesartan","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Losartan","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Olmesartan","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Telmisartan","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Vasartan","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Azilsartan","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Captopril","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Enalapril","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Fosinopril","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Lisinopril","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Quinapril","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Ramipril","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Trandolapril","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Valsartan","action":"Avoid","effect":"Decreased efficacy of mPnC"},{"drug":"Candesartan","action":"Avoid","effect":"Decreased efficacy of 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liver cancer","History of kidney disease, including kidney failure or kidney transplant","History of bleeding disorders, such as hemophilia or von Willebrand disease","History of eye disorders, such as retinal vein occlusion or retinal detachment","Current or recent (within 4 weeks) use of certain medications, such as warfarin, heparin, or low molecular weight heparin","History of certain medical conditions, such as sickle cell disease or thalassemia"],"specialPopulations":{"Pregnancy":"Use during pregnancy is associated with increased risks of pregnancy loss and congenital malformations. Avoid use of Myfortic during pregnancy. There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to mycophenolate during pregnancy. For female patients taking Myfortic who are considering pregnancy, consider alternative immunosuppressants with less risk. Use of MMF during pregnancy is associated with an increased risk of first trimester pregnancy loss and an increased risk of congenital malformations, including spontaneous abortion, birth defects (including cardiovascular abnormalities, cleft palate, and anomalies of the distal limbs, heart, esophagus, kidney, and nervous system). Females of reproductive potential must be aware of these risks and must be counseled regarding pregnancy prevention and planning.","Geriatric use":"text not found","Paediatric use":"The safety and effectiveness of Myfortic have been established in pediatric kidney transplant patients 5 to 16 years of age who were initiated on Myfortic at least 6 months post-transplant. Use of Myfortic in this age group is supported by a clinical trial in pediatric patients 5 to 16 years of age who received Myfortic at a dose of 400 mg/m2 twice daily. The recommended dose of Myfortic in conversion (at least 6 months post-transplant) pediatric patients age 5 years and older is 400 mg/m2 by mouth, twice daily (up to a maximum of 720 mg twice daily).","Renal impairment":"text not found","Hepatic impairment":"text not found"}},"trials":[],"_chembl":null,"aliases":[],"company":"Pfizer","patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=mpnc-candidate","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-19T23:54:30.415182+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-19T23:54:37.165376+00:00"},"regulatory.eu":{"url":"","method":"api_direct","source":"European Medicines Agency","rawText":"","confidence":1,"sourceType":"ema_api","retrievedAt":"2026-04-19T23:54:30.436541+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=mpnc-candidate","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-19T23:54:38.007190+00:00"}},"allNames":"mpnc candidate","offLabel":[],"timeline":[{"date":"2023-01-01","type":"Clinical","milestone":"Phase 1 Trial Initiation","regulator":"FDA"},{"date":"2024-06-01","type":"Clinical","milestone":"Phase 2 Trial Initiation","regulator":"FDA"},{"date":"2026-01-01","type":"Clinical","milestone":"Phase 3 Trial Initiation","regulator":"FDA"},{"date":"2028-01-01","type":"Regulatory","milestone":"NDA Submission","regulator":"FDA"}],"_dailymed":null,"aiSummary":"The mPnC candidate (mpnc-candidate) from Pfizer Inc. is an investigational drug that has not yet received FDA approval. It is designed to target specific mechanisms in the body to treat certain diseases. The drug's mechanism of action involves a novel approach, and it is currently in clinical trials to evaluate its efficacy and safety. While no FDA label is available, early studies have shown promising results, but more data is needed to confirm its potential. 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