{"id":"moxisylyte","rwe":[{"pmid":"39195685","year":"2024","title":"Comparative Study of the Effects of Drugs Targeting Adrenergic Receptors on the Early Life Stages of Zebrafish.","finding":"","journal":"Toxics","studyType":"Clinical Study"},{"pmid":"38644056","year":"2024","title":"A comprehensive history of injection therapy for erectile dysfunction, 1982-2023.","finding":"","journal":"Sexual medicine reviews","studyType":"Clinical Study"},{"pmid":"36385212","year":"2022","title":"Effects of adrenergic α-antagonists on the early life stages of Japanese medaka (Oryzias latipes).","finding":"","journal":"Ecotoxicology (London, England)","studyType":"Clinical Study"},{"pmid":"35047580","year":"2021","title":"Alterations of Gut Microbiome and Serum Metabolome in Coronary Artery Disease Patients Complicated With Non-alcoholic Fatty Liver Disease Are Associated With Adverse Cardiovascular Outcomes.","finding":"","journal":"Frontiers in cardiovascular medicine","studyType":"Clinical Study"},{"pmid":"33998674","year":"2021","title":"Vasodilators for primary Raynaud's phenomenon.","finding":"","journal":"The Cochrane database of systematic reviews","studyType":"Clinical Study"}],"tags":[{"label":"moxisylyte","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"C04AX10","category":"atc"},{"label":"Active","category":"status"},{"label":"Impotence","category":"indication"},{"label":"Raynaud's disease","category":"indication"},{"label":"Adrenergic Agents","category":"pharmacology"},{"label":"Adrenergic Antagonists","category":"pharmacology"},{"label":"Adrenergic alpha-Antagonists","category":"pharmacology"},{"label":"Cardiovascular Agents","category":"pharmacology"},{"label":"Miotics","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Sympatholytics","category":"pharmacology"},{"label":"Vasodilator Agents","category":"pharmacology"}],"phase":"marketed","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=MOXISYLYTE","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T01:05:49.665417+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T01:05:54.775925+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=MOXISYLYTE","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T01:05:55.554518+00:00"},"mechanism.target_chembl":{"url":"","method":"api_direct","source":"ChEMBL mechanism: Adrenergic receptor alpha antagonist","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T01:05:56.606218+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL159226/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T01:05:56.267196+00:00"}},"allNames":"moxilite","offLabel":[],"synonyms":["thymoxyalcylamine","acetoxythymoxamine","moxisylyte hydrochloride","moxisylyte HCl","moxisylyte","moxilite","moxisylite","moxisylyt","thymoxamine","timoxamina","moxisylyte hydrochoride","carlytene"],"timeline":[],"approvals":[],"brandName":"Moxilite","ecosystem":[{"indication":"Impotence","otherDrugs":[{"name":"alprostadil","slug":"alprostadil","company":"Pharmacia And Upjohn"},{"name":"avanafil","slug":"avanafil","company":"Vivus"},{"name":"sildenafil","slug":"sildenafil","company":"Pfizer Ireland"},{"name":"tadalafil","slug":"tadalafil","company":"Lilly"}],"globalPrevalence":null},{"indication":"Raynaud's disease","otherDrugs":[{"name":"isoxsuprine","slug":"isoxsuprine","company":""}],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","drugClass":"moxisylyte","explanation":"","oneSentence":"","technicalDetail":"Moxislyte acts as a vasodilator by inhibiting the contraction of smooth muscle cells in blood vessels, leading to an increase in blood flow and a decrease in blood pressure."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1855","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=MOXISYLYTE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:51:32.452421","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T01:05:57.887072+00:00","fieldsConflicting":1,"overallConfidence":0.8},"biosimilars":[],"competitors":[{"drugName":"phenoxybenzamine","drugSlug":"phenoxybenzamine","fdaApproval":"1953-01-26","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"moxisylyte","indications":{"approved":[{"name":"Impotence","source":"DrugCentral","snomedId":397803000,"regulator":"FDA"},{"name":"Raynaud's disease","source":"DrugCentral","snomedId":195295006,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"phenoxybenzamine","brandName":"phenoxybenzamine","genericName":"phenoxybenzamine","approvalYear":"1953","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000166510","NDDF":"003768","UNII":"PW8QYA7KI0","CHEBI":"CHEBI:94754","INN_ID":"1538","RXNORM":"10561","UMLSCUI":"C0040108","chemblId":"CHEMBL159226","ChEMBL_ID":"CHEMBL159226","KEGG_DRUG":"D08239","DRUGBANK_ID":"DB09205","PUBCHEM_CID":"4260","SNOMEDCT_US":"319442006","IUPHAR_LIGAND_ID":"12306","SECONDARY_CAS_RN":"964-52-3","MESH_DESCRIPTOR_UI":"D013948"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":65,"therapeuticAreas":["Hematology"],"atcClassification":{"source":"DrugCentral","atcCode":"C04AX10","allCodes":["C04AX10","G04BE06"]},"biosimilarFilings":[],"recentPublications":[{"date":"2024 Aug 10","pmid":"39195685","title":"Comparative Study of the Effects of Drugs Targeting Adrenergic Receptors on the Early Life Stages of Zebrafish.","journal":"Toxics"},{"date":"2024 Jun 26","pmid":"38644056","title":"A comprehensive history of injection therapy for erectile dysfunction, 1982-2023.","journal":"Sexual medicine reviews"},{"date":"2022 Dec","pmid":"36385212","title":"Effects of adrenergic α-antagonists on the early life stages of Japanese medaka (Oryzias latipes).","journal":"Ecotoxicology (London, England)"},{"date":"2021","pmid":"35047580","title":"Alterations of Gut Microbiome and Serum Metabolome in Coronary Artery Disease Patients Complicated With Non-alcoholic Fatty Liver Disease Are Associated With Adverse Cardiovascular Outcomes.","journal":"Frontiers in cardiovascular medicine"},{"date":"2021 May 17","pmid":"33998674","title":"Vasodilators for primary Raynaud's phenomenon.","journal":"The Cochrane database of systematic reviews"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"withdrawn","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"","enrichmentLevel":3,"visitCount":0,"regulatoryByCountry":[{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T01:05:57.887072+00:00","fieldsConflicting":1,"overallConfidence":0.8},"verificationStatus":"enriching","dataCompleteness":{"mechanism":false,"indications":true,"safety":false,"trials":false,"score":1}}