{"id":"moxifloxacin-and-dexamethasone-combined","safety":{"commonSideEffects":[{"rate":null,"effect":"Ocular irritation or discomfort"},{"rate":null,"effect":"Transient vision disturbance"},{"rate":null,"effect":"Conjunctival hyperemia"},{"rate":null,"effect":"Systemic corticosteroid effects (with prolonged use)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This combination targets bacterial infection through moxifloxacin's inhibition of essential bacterial enzymes required for DNA replication and transcription, while dexamethasone reduces local and systemic inflammatory responses. The synergistic approach aims to control infection while minimizing inflammatory complications, particularly relevant in ocular or respiratory conditions where both infection and inflammation are pathogenic drivers.","oneSentence":"Moxifloxacin (a fluoroquinolone antibiotic) inhibits bacterial DNA gyrase and topoisomerase IV, while dexamethasone (a corticosteroid) suppresses inflammation and immune response.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:22:09.163Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bacterial ocular infections with inflammatory component (phase 3 investigation)"},{"name":"Post-operative ocular inflammation and infection prophylaxis"}]},"trialDetails":[{"nctId":"NCT02735707","phase":"PHASE3","title":"Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia","status":"RECRUITING","sponsor":"UMC Utrecht","startDate":"2016-04-11","conditions":"Community-acquired Pneumonia, Influenza, COVID-19","enrollment":20000},{"nctId":"NCT00732446","phase":"PHASE3","title":"Safety/Efficacy of Antibiotic Steroid Combination in Treatment of Blepharitis and/or Keratitis and/or Conjunctivitis","status":"COMPLETED","sponsor":"Federal University of São Paulo","startDate":"2008-08","conditions":"Blepharitis, Conjunctivitis, Keratitis","enrollment":100},{"nctId":"NCT00870103","phase":"PHASE4","title":"Study of Efficacy and Safety of Vigadexa in Treating Inflammation and Infection Post-cataract Surgery","status":"COMPLETED","sponsor":"Alcon Research","startDate":"2008-09","conditions":"Cataract","enrollment":64},{"nctId":"NCT00330824","phase":"NA","title":"Efficacy/Safety of Antibiotic Steroid Combination in Prevention of Post Operative Inflammation in LASIK Surgery","status":"COMPLETED","sponsor":"Federal University of São Paulo","startDate":"2006-04","conditions":"Post Lasik Surgery Inflammation","enrollment":64},{"nctId":"NCT00331084","phase":"NA","title":"Efficacy/Safety of Antibiotic Steroid Combination in Prevention of Postoperative Inflammation in Cataract Surgery","status":"COMPLETED","sponsor":"Federal University of São Paulo","startDate":"2006-04","conditions":"Inflammation Following Cataract Surgery","enrollment":132}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["vigadexa"],"phase":"phase_3","status":"active","brandName":"Moxifloxacin and Dexamethasone combined","genericName":"Moxifloxacin and Dexamethasone combined","companyName":"Federal University of São Paulo","companyId":"federal-university-of-s-o-paulo","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Moxifloxacin (a fluoroquinolone antibiotic) inhibits bacterial DNA gyrase and topoisomerase IV, while dexamethasone (a corticosteroid) suppresses inflammation and immune response. Used for Bacterial ocular infections with inflammatory component (phase 3 investigation), Post-operative ocular inflammation and infection prophylaxis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}