{"id":"moviprep-2-day-split-dosing","safety":{"commonSideEffects":[{"rate":"20-30","effect":"Nausea"},{"rate":"5-15","effect":"Vomiting"},{"rate":"15-25","effect":"Abdominal pain or cramping"},{"rate":"10-20","effect":"Bloating"},{"rate":"5-10","effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"MOVIPREP contains polyethylene glycol (PEG) 3350, an osmotically active agent that retains water in the intestinal lumen, combined with electrolytes (sodium chloride, potassium chloride, sodium bicarbonate, sodium sulfate) to maintain electrolyte balance. The 2-day split-dosing regimen administers the solution in two divided doses to improve tolerability and patient compliance compared to single-day dosing.","oneSentence":"MOVIPREP is an osmotic laxative bowel preparation that draws water into the colon to cleanse it before medical procedures.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:50:17.011Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bowel cleansing prior to colonoscopy"},{"name":"Bowel cleansing prior to other gastrointestinal procedures"}]},"trialDetails":[{"nctId":"NCT04708366","phase":"PHASE4","title":"Colon Cleansing Efficacy With 1L vs. 2L vs. 4L-PEG for Colonoscopy Among Inpatients","status":"UNKNOWN","sponsor":"University of Bologna","startDate":"2021-02-01","conditions":"Colon Disease","enrollment":846},{"nctId":"NCT02273167","phase":"PHASE3","title":"Multicenter Randomized Parallel Group Phase III Study Comparing the Bowel Cleansing Efficacy, Safety and Tolerability of NER1006 Versus MOVIPREP® Using 2-Day Split-Dosing and 1-Day Morning Split-Dosing Regimen in Adults.","status":"COMPLETED","sponsor":"Norgine","startDate":"2014-10","conditions":"Colorectal Cancer, Colorectal Carcinoma, Colon Cleansing","enrollment":849}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"MOVIPREP, 2-Day Split-Dosing","genericName":"MOVIPREP, 2-Day Split-Dosing","companyName":"Norgine","companyId":"norgine","modality":"Small molecule","firstApprovalDate":"","aiSummary":"MOVIPREP is an osmotic laxative bowel preparation that draws water into the colon to cleanse it before medical procedures. Used for Bowel cleansing prior to colonoscopy, Bowel cleansing prior to other gastrointestinal procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}