{"id":"motilitone-and-pantoline","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Abdominal discomfort"},{"rate":null,"effect":"Nausea"}]},"_chembl":{"chemblId":"CHEMBL5314637","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Motilitone (itzaura) works through dual mechanisms: it blocks dopamine receptors (which normally inhibit gastric contractions) and inhibits acetylcholinesterase (allowing acetylcholine to accumulate and enhance muscle contractions). This combination promotes coordinated gastric muscle activity and accelerates the movement of food from the stomach into the small intestine, improving gastric motility.","oneSentence":"Motilitone enhances gastric muscle contractions and accelerates gastric emptying by acting as a dopamine antagonist and acetylcholinesterase inhibitor.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:55:56.820Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Functional dyspepsia"},{"name":"Gastroesophageal reflux disease (GERD)"},{"name":"Postoperative gastric stasis"}]},"trialDetails":[{"nctId":"NCT01817465","phase":"PHASE4","title":"A Study to Demonstrate the Efficacy and Safety of Motilitone®","status":"COMPLETED","sponsor":"Dong-A ST Co., Ltd.","startDate":"2012-08","conditions":"Functional Dyspepsia","enrollment":389},{"nctId":"NCT02162316","phase":"NA","title":"A Study to Evaluate the Efficacy Between Helicobacter Pylori Eradication Therapy and Motilitone in Functional Dyspepsia","status":"UNKNOWN","sponsor":"Chung-Ang University Hosptial, Chung-Ang University College of Medicine","startDate":"2014-07","conditions":"Functional Dyspepsia","enrollment":136}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Motilitone® and Pantoline®","genericName":"Motilitone® and Pantoline®","companyName":"Dong-A ST Co., Ltd.","companyId":"dong-a-st-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Motilitone enhances gastric muscle contractions and accelerates gastric emptying by acting as a dopamine antagonist and acetylcholinesterase inhibitor. Used for Functional dyspepsia, Gastric motility disorders.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}