{"id":"mosapride","rwe":[{"pmid":"41834860","year":"2026","title":"Based on untargeted metabolomics and metagenomics: a study on the mechanism of Miao ethnomedicine Zingiber mioga (Thunb.) Rosc. in treating slow transit constipation.","finding":"","journal":"Frontiers in microbiology","studyType":"Clinical Study"},{"pmid":"41814800","year":"2026","title":"[Efficacy comparison of Atractylodis Macrocephalae Rhizoma with different growth years in treatment of slow transit constipation and its mechanism].","finding":"","journal":"Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica","studyType":"Clinical Study"},{"pmid":"41737400","year":"2026","title":"Efficacy and safety of acupuncture for functional dyspepsia: an updated meta-analysis of randomized controlled trials.","finding":"","journal":"Frontiers in medicine","studyType":"Clinical Study"},{"pmid":"41735066","year":"2026","title":"[Effect of Zhuang-medicine medicated thread moxibustion on apoptosis-related protein expression in gastric smooth muscle tissue of diabetic gastroparesis rats based on ATF6/CHOP signaling pathway].","finding":"","journal":"Zhen ci yan jiu = Acupuncture research","studyType":"Clinical Study"},{"pmid":"41726311","year":"2026","title":"Radiofrequency Catheter Ablation-Induced Gastroparesis and Gastrointestinal Distension.","finding":"","journal":"Journal of the Belgian Society of Radiology","studyType":"Clinical Study"}],"tags":[{"label":"mosapride","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"5-hydroxytryptamine receptor 4","category":"target"},{"label":"HTR4","category":"gene"},{"label":"SIGMAR1","category":"gene"},{"label":"HTR2B","category":"gene"},{"label":"A03FA09","category":"atc"},{"label":"Active","category":"status"},{"label":"Gastrointestinal Agents","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"},{"label":"Serotonin Agents","category":"pharmacology"},{"label":"Serotonin Receptor Agonists","category":"pharmacology"}],"phase":"marketed","safety":{"safetySignals":[{"llr":178.23,"date":"","count":103,"signal":"Hepatic function abnormal","source":"DrugCentral FAERS","actionTaken":"Reported 103 times (LLR=178)"},{"llr":119.586,"date":"","count":96,"signal":"Interstitial lung disease","source":"DrugCentral FAERS","actionTaken":"Reported 96 times (LLR=120)"},{"llr":99.546,"date":"","count":113,"signal":"Platelet count decreased","source":"DrugCentral FAERS","actionTaken":"Reported 113 times (LLR=100)"},{"llr":86.104,"date":"","count":64,"signal":"Pneumonia aspiration","source":"DrugCentral FAERS","actionTaken":"Reported 64 times (LLR=86)"},{"llr":78.939,"date":"","count":52,"signal":"Cerebral infarction","source":"DrugCentral FAERS","actionTaken":"Reported 52 times (LLR=79)"},{"llr":71.133,"date":"","count":49,"signal":"Altered state of consciousness","source":"DrugCentral FAERS","actionTaken":"Reported 49 times (LLR=71)"},{"llr":63.664,"date":"","count":125,"signal":"Decreased appetite","source":"DrugCentral FAERS","actionTaken":"Reported 125 times (LLR=64)"},{"llr":56.235,"date":"","count":22,"signal":"Fatigue","source":"DrugCentral FAERS","actionTaken":"Reported 22 times (LLR=56)"},{"llr":55.885,"date":"","count":35,"signal":"Drug ineffective","source":"DrugCentral FAERS","actionTaken":"Reported 35 times (LLR=56)"},{"llr":55.705,"date":"","count":35,"signal":"Ileus","source":"DrugCentral FAERS","actionTaken":"Reported 35 times (LLR=56)"},{"llr":54.632,"date":"","count":19,"signal":"Upper respiratory tract inflammation","source":"DrugCentral FAERS","actionTaken":"Reported 19 times (LLR=55)"},{"llr":47.775,"date":"","count":69,"signal":"Cardiac failure","source":"DrugCentral FAERS","actionTaken":"Reported 69 times (LLR=48)"},{"llr":47.399,"date":"","count":64,"signal":"Aspartate aminotransferase increased","source":"DrugCentral FAERS","actionTaken":"Reported 64 times (LLR=47)"},{"llr":46.188,"date":"","count":69,"signal":"Renal impairment","source":"DrugCentral FAERS","actionTaken":"Reported 69 times (LLR=46)"},{"llr":44.281,"date":"","count":53,"signal":"Blood pressure decreased","source":"DrugCentral FAERS","actionTaken":"Reported 53 times (LLR=44)"}],"commonSideEffects":[{"effect":"Hepatic function abnormal","drugRate":"LLR 178","severity":"common"},{"effect":"Interstitial lung disease","drugRate":"LLR 120","severity":"common"},{"effect":"Platelet count decreased","drugRate":"LLR 100","severity":"common"},{"effect":"Pneumonia aspiration","drugRate":"LLR 86","severity":"common"},{"effect":"Cerebral infarction","drugRate":"LLR 79","severity":"common"},{"effect":"Altered state of consciousness","drugRate":"LLR 71","severity":"common"},{"effect":"Decreased appetite","drugRate":"LLR 64","severity":"common"},{"effect":"Fatigue","drugRate":"LLR 56","severity":"common"},{"effect":"Ileus","drugRate":"LLR 56","severity":"common"},{"effect":"Upper respiratory tract inflammation","drugRate":"LLR 55","severity":"common"},{"effect":"Cardiac failure","drugRate":"LLR 48","severity":"common"},{"effect":"Aspartate aminotransferase increased","drugRate":"LLR 47","severity":"common"},{"effect":"Renal impairment","drugRate":"LLR 46","severity":"common"},{"effect":"Blood pressure decreased","drugRate":"LLR 44","severity":"common"}]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"gasmotin","offLabel":[],"synonyms":["gasmotin","AS 4370","mosapride citrate hydrate","mosapride","mosapride citrate","mosapride citrate dihydrate","AS-4370"],"timeline":[{"date":"1998-01-01","type":"positive","source":"DrugCentral","milestone":"YEAR INTRODUCED approval"}],"aiSummary":"Gasmotin, also known as Mosapride, is a small molecule drug that targets the 5-hydroxytryptamine receptor 4. It belongs to the drug class of mosaprides and works by enhancing acetylcholine release in the gastrointestinal tract, thereby increasing gastrointestinal motility. Mosapride is used to treat gastrointestinal disorders such as gastroesophageal reflux disease (GERD) and functional dyspepsia. However, its commercial status and approval indications are unclear. As a pharma professional, it is essential to note that Mosapride's safety profile and pharmacokinetic properties require further investigation.","approvals":[{"date":"1998-01-01","orphan":false,"company":"","regulator":"YEAR INTRODUCED"}],"brandName":"Gasmotin","ecosystem":[],"mechanism":{"target":"Cytochrome P450 1A2, Cytochrome P450 2C19, Cytochrome P450 2C9","targets":[{"gene":"HTR4","source":"DrugCentral","target":"5-hydroxytryptamine receptor 4","protein":"5-hydroxytryptamine receptor 4"},{"gene":"SIGMAR1","source":"DrugCentral","target":"Sigma non-opioid intracellular receptor 1","protein":"Sigma non-opioid intracellular receptor 1"},{"gene":"HTR2B","source":"DrugCentral","target":"5-hydroxytryptamine receptor 2B","protein":"5-hydroxytryptamine receptor 2B"},{"gene":"HTR2C","source":"DrugCentral","target":"5-hydroxytryptamine receptor 2C","protein":"5-hydroxytryptamine receptor 2C"},{"gene":"CYP1A2","source":"DrugCentral","target":"Cytochrome P450 1A2","protein":"Cytochrome P450 1A2"},{"gene":"CYP3A4","source":"DrugCentral","target":"Cytochrome P450 3A4","protein":"Cytochrome P450 3A4"},{"gene":"ADRA2B","source":"DrugCentral","target":"Alpha-2B adrenergic receptor","protein":"Alpha-2B adrenergic receptor"},{"gene":"CYP2C19","source":"DrugCentral","target":"Cytochrome P450 2C19","protein":"Cytochrome P450 2C19"},{"gene":"CYP2C9","source":"DrugCentral","target":"Cytochrome P450 2C9","protein":"Cytochrome P450 2C9"},{"gene":"ADRA2A","source":"DrugCentral","target":"Alpha-2A adrenergic receptor","protein":"Alpha-2A adrenergic receptor"}],"modality":"Small Molecule","drugClass":"mosapride","explanation":"Think of Mosapride like a messenger that helps the muscles in your stomach and intestines move food through your digestive system more efficiently. This helps to prevent symptoms like heartburn and bloating. By increasing the release of acetylcholine, a natural chemical that stimulates muscle contractions, Mosapride helps to speed up digestion and relieve discomfort.","oneSentence":"Mosapride works by enhancing acetylcholine release in the gastrointestinal tract, increasing motility.","technicalDetail":"Mosapride acts as a selective 5-HT4 receptor agonist, which enhances the release of acetylcholine from the enteric nervous system, thereby increasing gastrointestinal motility and accelerating gastric emptying."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1848","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=MOSAPRIDE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=MOSAPRIDE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:51:03.614919","biosimilars":[],"competitors":[{"drugName":"metoclopramide","drugSlug":"metoclopramide","fdaApproval":"1979-02-07","patentExpiry":"Nov 17, 2038","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"cisapride","drugSlug":"cisapride","fdaApproval":"1993-07-29","patentStatus":"Unknown","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"mosapride","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"metoclopramide","brandName":"metoclopramide","genericName":"metoclopramide","approvalYear":"1979","relationship":"same-class"},{"drugId":"cisapride","brandName":"cisapride","genericName":"cisapride","approvalYear":"1993","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT07182890","phase":"PHASE4","title":"Efficacy of Clostridium Butyricum in Alleviating Anxiety and Depression in Patients With Functional Dyspepsia","status":"RECRUITING","sponsor":"Xijing Hospital of Digestive Diseases","startDate":"2025-09-20","conditions":["Functional Dyspepsia","Probiotics","Depression","Anxiety"],"enrollment":180,"completionDate":"2027-05-31"},{"nctId":"NCT07187492","phase":"PHASE4","title":"Efficacy of Bacillus Coagulans in Alleviating Anxiety and Depression in Patients With Functional Dyspepsia","status":"RECRUITING","sponsor":"Xijing Hospital of Digestive Diseases","startDate":"2025-09-20","conditions":["Functional Dyspepsia","Probiotics","Depression","Anxiety"],"enrollment":180,"completionDate":"2027-05-31"},{"nctId":"NCT07096921","phase":"NA","title":"The Effect of Two Prokinetics in Patients With Functional Dyspepsia","status":"ACTIVE_NOT_RECRUITING","sponsor":"Eunpyeong St. Mary's Hospital","startDate":"2025-07-08","conditions":["Functional Dyspepsia"],"enrollment":92,"completionDate":"2026-03-19"},{"nctId":"NCT06826443","phase":"PHASE3","title":"A Comparative Evaluation of Mosapride Versus Metoclopramide for Enteral Feeding Intolerance in Critically Ill Patients","status":"NOT_YET_RECRUITING","sponsor":"Ain Shams University","startDate":"2025-02","conditions":["Enteral Feeding Intolerance"],"enrollment":100,"completionDate":"2025-05"},{"nctId":"NCT06782594","phase":"PHASE2","title":"A Phase Ⅱ Study of Mosapride Citrate Injection in the Treatment of Postoperative Gastrointestinal Dysfunction","status":"RECRUITING","sponsor":"Shandong New Time Pharmaceutical Co., LTD","startDate":"2024-10-18","conditions":["Postoperative Gastrointestinal Dysfunction"],"enrollment":150,"completionDate":"2025-10"},{"nctId":"NCT04493125","phase":"NA","title":"Effect of Mosapride Citrate on Gastrointestinal Motility After Laparoscopic Gastrectomy","status":"COMPLETED","sponsor":"Gangnam Severance Hospital","startDate":"2020-07-27","conditions":["Stomach Cancer"],"enrollment":104,"completionDate":"2021-03-30"},{"nctId":"NCT06481371","phase":"NA","title":"Zuojin Wan Combined With Rabeprazole or Mosapride for the Treatment of Functional Dyspepsia Combined With Depression","status":"NOT_YET_RECRUITING","sponsor":"Nanjing First Hospital, Nanjing Medical University","startDate":"2024-06-30","conditions":["Functional Dyspepsia","Depression"],"enrollment":120,"completionDate":"2025-04-30"},{"nctId":"NCT06156995","phase":"NA","title":"Deep Needling at Zhongliao Point to Stimulate the Sacral Nerve for the Treatment of Slow Transit Constipation","status":"UNKNOWN","sponsor":"Guoliang Wu","startDate":"2023-01-01","conditions":["Constipation"],"enrollment":70,"completionDate":"2023-12-31"},{"nctId":"NCT05966246","phase":"NA","title":"The Effect of Prucalopride Succinate on Gastrointestinal Motility After Laparoscopic Gastrectomy : Prospective Double Blind Case-control Study","status":"COMPLETED","sponsor":"Gangnam Severance Hospital","startDate":"2022-01-25","conditions":["Gastric Cancer"],"enrollment":106,"completionDate":"2023-06-30"},{"nctId":"NCT05720442","phase":"PHASE1,PHASE2","title":"Efficacy Assessment of Chinese Herbal Medicine Tangweian Recipe Treating Participants With Diabetic Gastroenteropathy","status":"UNKNOWN","sponsor":"Guang'anmen Hospital of China Academy of Chinese Medical Sciences","startDate":"2023-02-01","conditions":["Diabetic Gastroenteropathy"],"enrollment":60,"completionDate":"2026-01-01"},{"nctId":"NCT02982668","phase":"NA","title":"Optimizing Early Enteral Nutrition in Severe Stroke","status":"TERMINATED","sponsor":"Xijing Hospital","startDate":"2017-01","conditions":["Severe Stroke","Acute Stroke","Dysphagia"],"enrollment":306,"completionDate":"2020-12"},{"nctId":"NCT04905147","phase":"NA","title":"Efficacy of Mosapride on Recovery of Intestinal Motility After Elective Colorectal Cancer Surgery","status":"UNKNOWN","sponsor":"Mahidol University","startDate":"2021-07-01","conditions":["Colorectal Cancer","Bowel Ileus"],"enrollment":44,"completionDate":"2023-11-30"},{"nctId":"NCT04350346","phase":"NA","title":"The Comparative Analysis Between Motilitone and Gasmotin for the Symptom Relief in Gallstone Patients With Functional Dyspepsia","status":"UNKNOWN","sponsor":"Yonsei University","startDate":"2020-03-25","conditions":["Gallstone"],"enrollment":70,"completionDate":"2021-09"},{"nctId":"NCT03149393","phase":"PHASE1,PHASE2","title":"Clinical Study on Post Evaluation After Listing of Qizhi Weitong Granules","status":"UNKNOWN","sponsor":"Xiyuan Hospital of China Academy of Chinese Medical Sciences","startDate":"2017-02-01","conditions":["Functional Dyspepsia","Traditional Chinese Medicine"],"enrollment":384,"completionDate":"2020-12-31"},{"nctId":"NCT03600974","phase":"","title":"A New System for GERD Diagnosis and Treatment","status":"UNKNOWN","sponsor":"Capital Medical University","startDate":"2019-02-01","conditions":["GERD"],"enrollment":200,"completionDate":"2021-07-01"},{"nctId":"NCT03477266","phase":"PHASE3","title":"Mouth Dissolving Mosapride Tables Enhance Post Cesarean Gut Recovery","status":"COMPLETED","sponsor":"Benha University","startDate":"2018-04-01","conditions":["Prevention of Postoperative Ileus"],"enrollment":400,"completionDate":"2018-08-01"},{"nctId":"NCT02180334","phase":"PHASE4","title":"The Effect of Combination of Mosapride and DPP-4 Inhibitor on Plasma Concentration of Incretin Hormones","status":"COMPLETED","sponsor":"Seoul National University Hospital","startDate":"2014-07","conditions":["Diabetes Mellitus, Type 2"],"enrollment":12,"completionDate":"2015-04"},{"nctId":"NCT03040817","phase":"NA","title":"Cooperative Group for Clinical Research in G-POEM (POP), Jiangsu, China","status":"UNKNOWN","sponsor":"Zhongda Hospital","startDate":"2017-09-01","conditions":["Gastric Peroral Endoscopic Pyloromyotomy (G-POEM)"],"enrollment":50,"completionDate":"2019-12-16"},{"nctId":"NCT03225248","phase":"PHASE3","title":"Efficacy and Safety of UI05MSP015CT in Functional Dyspepsia","status":"COMPLETED","sponsor":"Korea United Pharm. Inc.","startDate":"2014-11-05","conditions":["Functional Dyspepsia"],"enrollment":143,"completionDate":"2015-10-12"},{"nctId":"NCT02201316","phase":"PHASE1","title":"A Pilot Study to Determine the Relative Bioavailability of Mosapride 5mg From Two Candidate Formulations of GR107719B Relative to One 5mg Tablet of Reference Mosapride Citrate (GASMOTIN™) in Healthy Adult Human Subjects Under Fasting Conditions","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2014-02-03","conditions":["Gastritis"],"enrollment":18,"completionDate":"2014-03-18"},{"nctId":"NCT02887573","phase":"PHASE4","title":"Free-residue Nutrients for the Bowel Preparation of Colon Capsule Endoscopy","status":"UNKNOWN","sponsor":"Kaichun Wu","startDate":"2014-01","conditions":["Colorectal Polyps"],"enrollment":62,"completionDate":"2017-07"},{"nctId":"NCT02984930","phase":"NA","title":"Effect of Proton Pump Inhibitor and Mosapride on Acid Pocket in Gastroesophageal Reflux Disease","status":"UNKNOWN","sponsor":"Gangnam Severance Hospital","startDate":"2016-12","conditions":["Gastroesophageal Reflux Disease"],"enrollment":30,"completionDate":"2018-07"},{"nctId":"NCT02831543","phase":"PHASE3","title":"Clinical Trial to Assess the Efficacy and Safety of Combination Therapy of Motireb 5/100 mg in Functional Dyspepsia Patients.","status":"UNKNOWN","sponsor":"IlDong Pharmaceutical Co Ltd","startDate":"2016-04","conditions":["Functional Dyspepsia"],"enrollment":354,"completionDate":"2017-06"},{"nctId":"NCT02056405","phase":"PHASE4","title":"Effect of Mosapride on Postoperative Ileus in Patients Undergoing Colorectal Surgery","status":"UNKNOWN","sponsor":"Hospital Italiano de Buenos Aires","startDate":"2015-12","conditions":["Postoperative Ileus"],"enrollment":90,"completionDate":"2017-12"},{"nctId":"NCT01411501","phase":"PHASE3","title":"Efficacy and Safety of Acupuncture for Functional Constipation","status":"COMPLETED","sponsor":"Guang'anmen Hospital of China Academy of Chinese Medical Sciences","startDate":"2011-09","conditions":["Constipation"],"enrollment":684,"completionDate":"2014-12"},{"nctId":"NCT02606617","phase":"PHASE4","title":"A Clinical Trial Analyzing Effects of Prokinetic Drug on the Blood Glucose in Patients With Type 2 Diabetes","status":"UNKNOWN","sponsor":"Third Military Medical University","startDate":"2015-12","conditions":["Type 2 Diabetes"],"enrollment":200,"completionDate":"2016-12"},{"nctId":"NCT02433847","phase":"PHASE4","title":"Effect of Mosapride on Gut Transit in Patients With Chronic Constipation or Constipated Irritable Bowel Syndrome and Healthy Subjects","status":"UNKNOWN","sponsor":"Seoul National University Hospital","startDate":"2015-05","conditions":["Constipated Irritable Bowel Syndrome","Chronic Constipation","Healthy"],"enrollment":20,"completionDate":"2016-12"},{"nctId":"NCT01274793","phase":"PHASE1","title":"Trial for Quantity-Effect Relationship of Acupuncture With Two-ways Regulation to Treat Functional Enteropathy","status":"UNKNOWN","sponsor":"Huazhong University of Science and Technology","startDate":"2010-11","conditions":["Functional Constipation","Functional Diarrhea"],"enrollment":240,"completionDate":"2015-12"},{"nctId":"NCT01781897","phase":"PHASE1","title":"Electroacupuncture for the Treatment of Functional Constipation","status":"UNKNOWN","sponsor":"Huazhong University of Science and Technology","startDate":"2013-02","conditions":["Functional Constipation"],"enrollment":243,"completionDate":"2015-12"},{"nctId":"NCT02264587","phase":"PHASE4","title":"Effects and Mechanism of Mosapride Citrate on Diabetic Gastroparesis","status":"UNKNOWN","sponsor":"Liangzhou Wei","startDate":"2014-10","conditions":["Diabetic Gastroparesis"],"enrollment":60,"completionDate":"2015-12"},{"nctId":"NCT02106130","phase":"PHASE1","title":"A Drug Interaction Study of Mosapride and Rebamipide","status":"COMPLETED","sponsor":"IlDong Pharmaceutical Co Ltd","startDate":"2013-05","conditions":["Healthy"],"enrollment":40,"completionDate":"2013-08"},{"nctId":"NCT01984931","phase":"PHASE3","title":"Study of Trimebutine Maleate (NEWBUTIN SR 300 mg Tab)for Treatment of Post Operative Nausea and Vomiting","status":"UNKNOWN","sponsor":"CM Chungmu Hospital","startDate":"2013-10","conditions":["Nausea","Vomiting"],"enrollment":45,"completionDate":"2013-12"},{"nctId":"NCT00742872","phase":"PHASE3","title":"Randomized Trial of Mosapride Versus Placebo in the Treatment of Constipation-Predominant Irritable Bowel Syndrome","status":"TERMINATED","sponsor":"American University of Beirut Medical Center","startDate":"2008-09","conditions":["Constipation-Predominant Irritable Bowel Syndrome"],"enrollment":41,"completionDate":"2010-06"},{"nctId":"NCT01505777","phase":"PHASE2","title":"Exploratory Clinical Study to Evaluate the Optimal Dosage of Mosapride and Probiotics in Irritable Bowel Syndrome Without Predominant Diarrhea","status":"COMPLETED","sponsor":"Hanmi Pharmaceutical Company Limited","startDate":"2011-05","conditions":["Irritable Bowel Syndrome Without Diarrhea"],"enrollment":280,"completionDate":"2012-06"},{"nctId":"NCT01284764","phase":"PHASE3","title":"Efficacy Study of a Low Volume of Water Intake and Mosapride for Endoscopy in Patients With Subtotal Gastrectomy","status":"COMPLETED","sponsor":"Inje University","startDate":"2011-01","conditions":["Foreign Body Left During Endoscopic Examination"],"enrollment":144,"completionDate":"2011-09"},{"nctId":"NCT01094847","phase":"PHASE1","title":"Clinical Trials to Compare Mosapride Bioavailability Between DWJ1252 and Mosapride Medicine","status":"COMPLETED","sponsor":"Daewoong Pharmaceutical Co. LTD.","startDate":"2010-04","conditions":["Bioequivalence"],"enrollment":30,"completionDate":""},{"nctId":"NCT00663897","phase":"PHASE4","title":"Lansoprazole Versus Mosapride for Functional Dyspepsia","status":"COMPLETED","sponsor":"Lotung Poh-Ai Hospital","startDate":"2008-05","conditions":["Functional Dyspepsia","Epigastric Pain Syndrome","Post Prandial Distress Syndrome"],"enrollment":329,"completionDate":"2009-09"},{"nctId":"NCT00729339","phase":"PHASE4","title":"Role of Mosapride in Patients With Gastroesophageal Reflux Disease","status":"COMPLETED","sponsor":"Lotung Poh-Ai Hospital","startDate":"2008-06","conditions":["Gastroesophageal Reflux Disease"],"enrollment":114,"completionDate":"2009-05"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NDDF":"008862","UNII":"I8MFJ1C0BY","CHEBI":"CHEBI:94373","INN_ID":"6855","RXNORM":"135091","UMLSCUI":"C0526501","ChEMBL_ID":"CHEMBL60889","KEGG_DRUG":"D01994","DRUGBANK_ID":"DB11675","PUBCHEM_CID":"119584","SNOMEDCT_US":"1163443001","IUPHAR_LIGAND_ID":"242","SECONDARY_CAS_RN":"112885-42-4","MESH_SUPPLEMENTAL_RECORD_UI":"C062720"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":456,"therapeuticAreas":["Cardiovascular"],"atcClassification":{"source":"DrugCentral","atcCode":"A03FA09","allCodes":["A03FA09"]},"biosimilarFilings":[],"recentPublications":[{"date":"2026","pmid":"41834860","title":"Based on untargeted metabolomics and metagenomics: a study on the mechanism of Miao ethnomedicine Zingiber mioga (Thunb.) Rosc. in treating slow transit constipation.","journal":"Frontiers in microbiology"},{"date":"2026 Feb","pmid":"41814800","title":"[Efficacy comparison of Atractylodis Macrocephalae Rhizoma with different growth years in treatment of slow transit constipation and its mechanism].","journal":"Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica"},{"date":"2026","pmid":"41737400","title":"Efficacy and safety of acupuncture for functional dyspepsia: an updated meta-analysis of randomized controlled trials.","journal":"Frontiers in medicine"},{"date":"2026 Feb 25","pmid":"41735066","title":"[Effect of Zhuang-medicine medicated thread moxibustion on apoptosis-related protein expression in gastric smooth muscle tissue of diabetic gastroparesis rats based on ATF6/CHOP signaling pathway].","journal":"Zhen ci yan jiu = Acupuncture research"},{"date":"2026","pmid":"41726311","title":"Radiofrequency Catheter Ablation-Induced Gastroparesis and Gastrointestinal Distension.","journal":"Journal of the Belgian Society of Radiology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","enrichmentLevel":3,"visitCount":0,"regulatoryByCountry":[{"country_code":"OTHER","regulator":"YEAR INTRODUCED","status":"approved","approval_date":"1998-01-01T00:00:00.000Z","mah":"","brand_name_local":null,"application_number":""},{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":3,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":false,"safety":true,"trials":true,"score":3}}