{"id":"morphine-sulfate-sustained-release-tablets","safety":{"commonSideEffects":[{"rate":"40-60","effect":"Constipation"},{"rate":"20-40","effect":"Nausea"},{"rate":"20-30","effect":"Drowsiness/Sedation"},{"rate":"10-20","effect":"Dizziness"},{"rate":"10-20","effect":"Vomiting"},{"rate":null,"effect":"Respiratory depression"},{"rate":"5-15","effect":"Pruritus"}]},"_chembl":{"chemblId":"CHEMBL2103744","moleculeType":"Small molecule","molecularWeight":"758.84"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Morphine is a mu-opioid receptor agonist that modulates pain signaling by binding to opioid receptors in the brain and spinal cord, reducing the transmission and perception of pain signals. The sustained-release formulation provides prolonged drug delivery over an extended period, allowing for less frequent dosing in chronic pain management. This formulation is particularly useful in cancer pain management where continuous analgesia is required.","oneSentence":"Morphine sulfate binds to opioid receptors in the central nervous system to reduce pain perception and provide analgesia.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:22:04.661Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cancer pain management"},{"name":"Moderate to severe chronic pain in cancer patients"}]},"trialDetails":[{"nctId":"NCT05265052","phase":"PHASE2","title":"3D1002 in Combination With Oxycodone Hydrochloride Sustained-release Tablets in Patients With Moderate to Severe Cancer Pain","status":"NOT_YET_RECRUITING","sponsor":"3D Medicines","startDate":"2026-12","conditions":"Cancer Pain","enrollment":177},{"nctId":"NCT04785768","phase":"PHASE3","title":"IV PCA With or Without Continuous Dose vs Oral Opioid to Maintain Analgesia for Severe Cancer Pain After Successful Titration","status":"COMPLETED","sponsor":"Fujian Cancer Hospital","startDate":"2021-07-01","conditions":"Cancer Pain","enrollment":1372},{"nctId":"NCT06897917","phase":"PHASE4","title":"Real World Study of Oxycodone/Naloxone Sustained-Release Tablets (Mimeixin) for Patients With Severe Cancer Pain","status":"NOT_YET_RECRUITING","sponsor":"Henan Cancer Hospital","startDate":"2025-04","conditions":"Opioid-Induced Constipation, Pain Cancer","enrollment":203},{"nctId":"NCT04549818","phase":"NA","title":"Analgesic Efficacy of Sacral Neuromodulation for Pelvic Cancer Pain: A Preliminary Report","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2020-09-10","conditions":"Chronic Pain","enrollment":44},{"nctId":"NCT04132011","phase":"PHASE4","title":"Dosing Intervals of Opioid Medication for Chronic Pain","status":"WITHDRAWN","sponsor":"University Health Network, Toronto","startDate":"2019-05-01","conditions":"Chronic Pain","enrollment":""},{"nctId":"NCT02429050","phase":"PHASE4","title":"Morphine for Treatment of Dyspnea in Patients With COPD","status":"COMPLETED","sponsor":"Maastricht University Medical Center","startDate":"2016-11-16","conditions":"Pulmonary Disease, Chronic Obstructive","enrollment":124},{"nctId":"NCT03967327","phase":"PHASE3","title":"A Study to Evaluate Buprenorphine Transdermal Patch in Chinese Subjects With Moderate to Severe Chronic Cancer Pain","status":"UNKNOWN","sponsor":"Mundipharma (China) Pharmaceutical Co. Ltd","startDate":"2019-04-22","conditions":"Cancer Pain","enrollment":194},{"nctId":"NCT02198924","phase":"PHASE4","title":"Efficacy and Safety of Postoperative Intravenous Parecoxib Sodium Followed by Oral Celecoxib in Osteoarthritis Patients","status":"COMPLETED","sponsor":"Peking Union Medical College Hospital","startDate":"2014-12","conditions":"Pain, Inflammation","enrollment":246},{"nctId":"NCT01549652","phase":"NA","title":"5HT3 Antagonists to Treat Opioid Withdrawal and to Prevent the Progression of Physical Dependence","status":"COMPLETED","sponsor":"Stanford University","startDate":"2011-04","conditions":"Opioid Withdrawal, Physical Dependence","enrollment":133},{"nctId":"NCT00314340","phase":"PHASE4","title":"A Comparison of the Addiction Liability of Hydrocodone and Sustained Release Morphine","status":"COMPLETED","sponsor":"University of California, Davis","startDate":"2005-11","conditions":"Chronic Pain","enrollment":12},{"nctId":"NCT00943566","phase":"PHASE2","title":"A Safety and Efficacy Study of Sufentanil Transdermal System in Patients With Chronic Pain Due to Cancer","status":"WITHDRAWN","sponsor":"Labtec GmbH","startDate":"2010-01","conditions":"Chronic Pain","enrollment":""},{"nctId":"NCT00805142","phase":"PHASE2","title":"Phase 2 Study of Tapentadol Prolonged Release in Cancer Pain Participants","status":"COMPLETED","sponsor":"Janssen Pharmaceutical K.K.","startDate":"2008-11","conditions":"Pain, Cancer","enrollment":78},{"nctId":"NCT01309386","phase":"PHASE3","title":"A Safety and Efficacy Study of Oral Tapentadol Extended-Release in Japanese Participants","status":"COMPLETED","sponsor":"Janssen Pharmaceutical K.K.","startDate":"2010-08","conditions":"Neoplasms","enrollment":100}],"_emaApprovals":[],"_faersSignals":[{"count":1,"reaction":"PLATELET COUNT DECREASED"},{"count":1,"reaction":"PNEUMONIA"}],"_approvalHistory":[],"publicationCount":7,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Morphine Sulfate Sustained-release Tablets","genericName":"Morphine Sulfate Sustained-release Tablets","companyName":"Fujian Cancer Hospital","companyId":"fujian-cancer-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Morphine Sulfate Sustained-release Tablets are a type of medication classified as a mu opioid receptor agonist. They are used to treat various conditions, including cancer pain, chronic pain, and opioid-induced constipation, among others.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}