{"id":"morphine-plus-ketamine","safety":{"commonSideEffects":[{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Sedation"},{"rate":null,"effect":"Dissociation (ketamine-related)"},{"rate":null,"effect":"Respiratory depression"}]},"_chembl":{"chemblId":"CHEMBL742","moleculeType":"Small molecule","molecularWeight":"237.73"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Morphine binds to mu-opioid receptors to reduce pain perception and emotional response to pain. Ketamine antagonizes NMDA glutamate receptors, which are involved in pain signal amplification and opioid tolerance development. The combination may allow lower opioid doses while maintaining or improving analgesia and potentially reducing adverse effects associated with high-dose opioid monotherapy.","oneSentence":"Morphine and ketamine together provide analgesia through complementary pathways: morphine acts as an opioid receptor agonist while ketamine blocks NMDA receptors, potentially reducing opioid tolerance and enhancing pain relief.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:22:03.724Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Moderate to severe pain (phase 3 indication under investigation)"}]},"trialDetails":[{"nctId":"NCT07435077","phase":"PHASE4","title":"Examining Analgesic Synergy and Efficacy in Trauma Care","status":"NOT_YET_RECRUITING","sponsor":"Wake Forest University Health Sciences","startDate":"2026-05","conditions":"Opioid Use Disorder","enrollment":282},{"nctId":"NCT07489001","phase":"","title":"Opioid Free and Opioid Based Anesthesia in Elective Lumbar Spine Surgery","status":"RECRUITING","sponsor":"Marmara University","startDate":"2025-12-09","conditions":"Lumbar Spinal Stenosis, Lumbar Disc Herniation With Radiculopathy, Lumbar Degenerative Spondylolisthesis","enrollment":75},{"nctId":"NCT07455565","phase":"NA","title":"Postoperative Pain Monitoring With ANI in Lumbar Spine Surgery","status":"RECRUITING","sponsor":"Akdeniz University Hospital","startDate":"2025-12-16","conditions":"Postoperative Pain, Lumbar Spine Surgery","enrollment":100},{"nctId":"NCT07452705","phase":"NA","title":"Small Study Comparing Two Pain Medicines in Teenagers for Pain Control After Scoliosis Corrective Surgery.","status":"NOT_YET_RECRUITING","sponsor":"University of Malaya","startDate":"2026-02-02","conditions":"Adolescent Idiopathic Scoliosis (AIS)","enrollment":114},{"nctId":"NCT07059429","phase":"NA","title":"Ketamine Administration for Postoperative Pain Management in Patients Undergoing Knee Arthroplasty","status":"COMPLETED","sponsor":"State Budgetary Healthcare Institution, National Medical Surgical Center N.A. N.I. Pirogov, Ministry of Health of Russia","startDate":"2025-07-01","conditions":"Knee Arthroplasty, Postoperative Pain, Pain Management","enrollment":100},{"nctId":"NCT07337135","phase":"NA","title":"Opioid-Free vs Opioid-Based Anesthesia in Bariatric Surgery","status":"COMPLETED","sponsor":"Hospital dos Lusíadas","startDate":"2023-10-02","conditions":"Morbid Obesity, Postoperative Pain, Opioid Free Anesthesia","enrollment":60},{"nctId":"NCT07414706","phase":"PHASE3","title":"Intravenous Lidocaine Plus Port-Site Ropivacaine for Recovery After Laparoscopic Surgery","status":"NOT_YET_RECRUITING","sponsor":"Centre Hospitalier Universitaire, Amiens","startDate":"2026-03","conditions":"Intravenous Lidocaine, Laparoscopic Surgery, Post Operative Recovery","enrollment":182},{"nctId":"NCT06835504","phase":"PHASE3","title":"Morphine or Ketamine for Analgesia","status":"NOT_YET_RECRUITING","sponsor":"Columbia University","startDate":"2026-05-01","conditions":"Abdominal Pain, Isolated Extremity Fracture, Pain","enrollment":1010},{"nctId":"NCT03756961","phase":"NA","title":"Effects of an Opioid Free/Sparing Care Pathway for Patients Undergoing Obesity Surgery","status":"RECRUITING","sponsor":"Göteborg University","startDate":"2019-05-01","conditions":"Obesity, Pain, Postoperative","enrollment":220},{"nctId":"NCT06868589","phase":"PHASE4","title":"Reducing Pain With Methadone and Ketamine in Liver Transplant","status":"RECRUITING","sponsor":"Lahey Clinic","startDate":"2025-06-30","conditions":"Liver Transplantation","enrollment":50},{"nctId":"NCT01594047","phase":"NA","title":"Perioperative Opioid-induced Hyperalgesia and Its Prevention With Ketamine and Methadone","status":"COMPLETED","sponsor":"Fondazione IRCCS Istituto Nazionale dei Tumori, Milano","startDate":"2009-12-01","conditions":"Post Operative Pain, Hyperalgesia","enrollment":113},{"nctId":"NCT06381063","phase":"PHASE3","title":"Non-steroidal Anti-inflammatory in Cardiac Surgery","status":"RECRUITING","sponsor":"Centre Hospitalier Universitaire, Amiens","startDate":"2024-03-27","conditions":"Acute Postoperative Pain, Non-steroidal Anti-inflammatory Drugs, Cardiac Surgery","enrollment":238},{"nctId":"NCT07075302","phase":"","title":"OFA vs OBA in Bariatric Surgery","status":"COMPLETED","sponsor":"Hospital HM Nou Delfos","startDate":"2022-06-01","conditions":"Obesity, Postoperative Pain, Bariatric Surgery","enrollment":70},{"nctId":"NCT06429657","phase":"PHASE4","title":"Ketamine for Sedation in Severe Traumatic Brain Injury","status":"SUSPENDED","sponsor":"Henry M. Jackson Foundation for the Advancement of Military Medicine","startDate":"2024-09-23","conditions":"Severe Traumatic Brain Injury, Intracranial Hypertension, Intracranial Hemorrhage, Hypertensive","enrollment":50},{"nctId":"NCT06404983","phase":"NA","title":"Opioid-free Anaesthesia in Breast Cancer Surgery","status":"RECRUITING","sponsor":"University of Ioannina","startDate":"2022-12-28","conditions":"Breast Cancer, Anesthesia, Pain, Postoperative","enrollment":200},{"nctId":"NCT03431285","phase":"NA","title":"Ketamine for Acute Painful Crisis in Sickle Cell Disease Patients","status":"COMPLETED","sponsor":"Imam Abdulrahman Bin Faisal University","startDate":"2018-01-01","conditions":"Sickle Cell Crisis","enrollment":278},{"nctId":"NCT02202369","phase":"PHASE4","title":"Multimodal Analgesia vs. Routine Care Pain Management for Lumbar Spine Fusion Surgery: A Prospective Randomized Study","status":"SUSPENDED","sponsor":"OrthoCarolina Research Institute, Inc.","startDate":"2015-06-25","conditions":"Single Level Lumbar Decompression and Fusion Spine Surgery","enrollment":50},{"nctId":"NCT06774274","phase":"PHASE4","title":"Analgesic Efficacy of Intravenous Ketamine as a Continuous Infusion vs PCA in the Management of Acute Postoperative Pain in Major Orthopedic Surgery.","status":"RECRUITING","sponsor":"Universidad de Antioquia","startDate":"2025-03-01","conditions":"Pain, Postoperative, Opioid Use, Major Surgery","enrollment":120},{"nctId":"NCT06003218","phase":"NA","title":"Dexmedetomidine-esketamine for Percutaneous Radiofrequency Liver Ablation","status":"COMPLETED","sponsor":"Peking University First Hospital","startDate":"2023-10-16","conditions":"Liver Cancer, Radiofrequency Ablation, Esketamine","enrollment":88},{"nctId":"NCT05345639","phase":"PHASE3","title":"Chest Wall Block After Sternotomy: Randomized Controlled Trial in Cardiac Surgery: (PABLOS Study)","status":"COMPLETED","sponsor":"University Hospital, Angers","startDate":"2022-08-01","conditions":"Pain, Postoperative, Cardiac Surgery","enrollment":254},{"nctId":"NCT05679375","phase":"PHASE4","title":"IV and Intrathecal Ketamine in Cesarean Section","status":"COMPLETED","sponsor":"Assiut University","startDate":"2023-02-01","conditions":"Cesarean Section, Analgesia","enrollment":60},{"nctId":"NCT04894864","phase":"PHASE4","title":"Opioid Free Anesthesia-Analgesia Strategy and Surgical Stress in Elective Open Abdominal Aortic Aneurysm Repair","status":"RECRUITING","sponsor":"University of Crete","startDate":"2020-10-08","conditions":"Elective Surgical Procedures, Postoperative Pain, Anesthesia","enrollment":40},{"nctId":"NCT03596424","phase":"NA","title":"Dexmedetomidine and Ketamine in VATS Surgery","status":"RECRUITING","sponsor":"Ciusss de L'Est de l'Île de Montréal","startDate":"2018-02-01","conditions":"Postoperative Pain, Opioid Use","enrollment":120},{"nctId":"NCT06463899","phase":"NA","title":"Evaluation of the Effectiveness of the Administration of Local Anesthetics Via Two Catheters Placed During Surgery, and Study of the Benefits on Respiratory Function and Therefore on Recovery Time","status":"RECRUITING","sponsor":"CHU de Reims","startDate":"2023-02-08","conditions":"Duration of Hospitalization in Intensive Care Unit","enrollment":114},{"nctId":"NCT02543385","phase":"NA","title":"S Ketamine Use in Total Abdominal Hysterectomy","status":"WITHDRAWN","sponsor":"KK Women's and Children's Hospital","startDate":"2014-06","conditions":"Total Abdominal Hysterectomy","enrollment":""},{"nctId":"NCT06473896","phase":"NA","title":"Effect of Ketalar or Dexmedetomidine on Increased Sensitivity to Pain Following Treatment With Remifentanil","status":"RECRUITING","sponsor":"Assaf-Harofeh Medical Center","startDate":"2024-04-18","conditions":"Cholecystectomy","enrollment":90},{"nctId":"NCT05591105","phase":"","title":"The Postoperative Lidocaine and Ketamine Effects on Morphine Requirement in Bariatric Surgery","status":"COMPLETED","sponsor":"Tiva Group","startDate":"2023-06-15","conditions":"Pharmacological Action, Post Operative Pain, Opioid Use","enrollment":64},{"nctId":"NCT06408974","phase":"PHASE4","title":"Comparison Between Ketamine Intrathecal and iv Dexamethasone for Post Cesarean Analgesia","status":"NOT_YET_RECRUITING","sponsor":"Assiut University","startDate":"2024-12-01","conditions":"Post Cesarean Analgesia","enrollment":90},{"nctId":"NCT00701909","phase":"PHASE3","title":"Pain Medicine for Wound Care Procedures","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2008-06","conditions":"Wound Care, Pain Intensity, Hyperalgesia","enrollment":12},{"nctId":"NCT05752799","phase":"NA","title":"Evaluation of the Stress Response in Bariatric Surgery With and Without the Use of Opioids","status":"RECRUITING","sponsor":"G.Gennimatas General Hospital","startDate":"2023-01-01","conditions":"Opioid Use, Unspecified, Bariatric Surgery Candidate","enrollment":70},{"nctId":"NCT06191770","phase":"NA","title":"Comparison of Morphine With Nalbuphine in a Multimodal Approach for Pain Relief in Patients Undergoing Gynecological Procedures: Randomized Controlled Double Blind Clinical Trial","status":"COMPLETED","sponsor":"Aga Khan University Hospital, Pakistan","startDate":"2019-10-01","conditions":"Pain, Acute","enrollment":66},{"nctId":"NCT06113497","phase":"PHASE4","title":"A Prospective Study on the Comparison of Postoperative Pain According to the Use of Cocktail Therapy in Laminoplasty","status":"UNKNOWN","sponsor":"Kyunghee University Medical Center","startDate":"2023-11-25","conditions":"Adverse Effects in the Therapeutic Use of Analgesic, Antipyretic and Anti-Inflammatory Drug, Unspecified","enrollment":60},{"nctId":"NCT05422001","phase":"PHASE4","title":"Low-dose KETamine as an Adjunct to MOrphine for Acute Pain in the ED","status":"TERMINATED","sponsor":"University of Aarhus","startDate":"2022-05-31","conditions":"Acute Pain, Opioid Use","enrollment":116},{"nctId":"NCT06021717","phase":"PHASE4","title":"PCA Ketamine-Morphine VS PCA Morphine as Post-Operative Analgesia in Colorectal Surgery","status":"COMPLETED","sponsor":"Universiti Kebangsaan Malaysia Medical Centre","startDate":"2018-04-05","conditions":"Ketamine, Morphine","enrollment":60},{"nctId":"NCT06010056","phase":"PHASE4","title":"PCA Ketamine-Morphine VS PCA Morphine as Post-Operative Analgesia in Colorectal Surgery.","status":"COMPLETED","sponsor":"National University of Malaysia","startDate":"2018-04-05","conditions":"Ketamine, Morphine","enrollment":60},{"nctId":"NCT01900847","phase":"NA","title":"Ketamine and Morphine Versus Morphine Alone for the Treatment of Acute Pain in the Emergency Department","status":"TERMINATED","sponsor":"University of Arizona","startDate":"2013-06-01","conditions":"Acute Pain","enrollment":17},{"nctId":"NCT04852484","phase":"NA","title":"Morphine Versus Ketamine as Adjuvants in Paravertebral Blocks","status":"UNKNOWN","sponsor":"Aretaieion University Hospital","startDate":"2021-04-16","conditions":"Pain, Postoperative, Pain, Acute, Pain, Chronic","enrollment":90},{"nctId":"NCT03236805","phase":"PHASE3","title":"Intravenous Subdissociative-dose Ketamine Versus Morphine for Prehospital Analgesia","status":"TERMINATED","sponsor":"Nantes University Hospital","startDate":"2017-11-23","conditions":"Pain Management","enrollment":285},{"nctId":"NCT03396692","phase":"NA","title":"PEF-Block & Ribs Fractures","status":"COMPLETED","sponsor":"University Hospital, Montpellier","startDate":"2018-06-18","conditions":"Chest Trauma With Ribs Fractures","enrollment":90},{"nctId":"NCT05582135","phase":"NA","title":"Postoperative Analgesic Effect of Esketamine","status":"COMPLETED","sponsor":"Xuanhan County People's Hospital","startDate":"2021-05-05","conditions":"Gynecological; Surgery (Previous), Affecting Fetus or Newborn, Due to Obstructed Labor, Analgesia","enrollment":119},{"nctId":"NCT05200806","phase":"PHASE4","title":"A Prospective Pilot Study of a Non-Narcotic Post-Operative Course After Colectomy","status":"UNKNOWN","sponsor":"University of Vermont","startDate":"2022-02-07","conditions":"Analgesia, Post-Operative Pain, Breakthrough Pain","enrollment":25},{"nctId":"NCT04421196","phase":"NA","title":"Opioid-free Total Hip Arthroplasty","status":"WITHDRAWN","sponsor":"Johns Hopkins University","startDate":"2022-09-15","conditions":"Hip Osteoarthritis","enrollment":""},{"nctId":"NCT03751423","phase":"PHASE3","title":"Intravenous Ketamine for Pain Control During First Trimester Surgical Abortion","status":"SUSPENDED","sponsor":"Dr. Marie Eve Sophie Bussiere-Cote","startDate":"2019-06-10","conditions":"Abortion in First Trimester","enrollment":123},{"nctId":"NCT05515822","phase":"PHASE4","title":"Use of Oxycodone in Bariatric Surgery","status":"UNKNOWN","sponsor":"Qiang Fu","startDate":"2022-10-01","conditions":"Pain, Postoperative","enrollment":90},{"nctId":"NCT04061330","phase":"PHASE2","title":"Comparison of Low-dose Ketamine to Opioids in the Management of Acute Pain in Patients Presenting to the Emergency Department With Long Bone Fractures","status":"WITHDRAWN","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2022-01-01","conditions":"Pain, Acute","enrollment":""},{"nctId":"NCT05172739","phase":"PHASE4","title":"Opioid Free Anaesthesia-Analgesia Strategy on Surgical Stress and Immunomodulation in Elective VATS-Lobectomy for NSCLC","status":"RECRUITING","sponsor":"University of Crete","startDate":"2021-10-01","conditions":"Systemic Inflammatory Response Syndrome, Postoperative Pain, Acute, Postoperative Pain, Chronic","enrollment":70},{"nctId":"NCT05163366","phase":"PHASE3","title":"Oral Morphine Versus Ketamine in Pain Management","status":"COMPLETED","sponsor":"Mbarara University of Science and Technology","startDate":"2021-03-01","conditions":"Pain, Procedural","enrollment":44},{"nctId":"NCT04223219","phase":"PHASE4","title":"Different Modalities of Analgesia in Open Heart Surgeries in Mansoura University","status":"UNKNOWN","sponsor":"Mansoura University","startDate":"2019-12-10","conditions":"Coronary Artery Disease, Valve Disease, Heart, Pain, Acute","enrollment":90},{"nctId":"NCT04085588","phase":"","title":"Low Dose Ketamine Infusion for Postoperative Analgesia After Total Knee Arthroplasty","status":"COMPLETED","sponsor":"Mustafa Kemal University","startDate":"2019-04-15","conditions":"Postoperative Pain","enrollment":75},{"nctId":"NCT02570230","phase":"PHASE4","title":"Ketamine Combination With Spinal Morphine for Post Thoracic Surgery Pain : A Randomized Control Study","status":"COMPLETED","sponsor":"Mahidol University","startDate":"2017-10-01","conditions":"Pain, Postoperative Period","enrollment":32},{"nctId":"NCT04009759","phase":"PHASE1","title":"Influence of Morphine or Ketamine or Saline Applied During In-hospital Cardiopulmonary Resuscitation on Early Survival","status":"UNKNOWN","sponsor":"University Hospital, Akershus","startDate":"2021-10-01","conditions":"Cardiac Arrest","enrollment":240},{"nctId":"NCT03296345","phase":"PHASE2","title":"Adjuvant Low-dose Ketamine in Pediatric Sickle Cell Vaso-occlusive Crisis","status":"COMPLETED","sponsor":"UCSF Benioff Children's Hospital Oakland","startDate":"2016-06","conditions":"Sickle Cell Disease, Vaso-Occlusive Crisis","enrollment":62},{"nctId":"NCT04698772","phase":"","title":"Patient Satisfaction With Subdissociative Dose Ketamine Versus Morphine for Emergency Department Pain Control","status":"COMPLETED","sponsor":"CHRISTUS Health","startDate":"2019-12-19","conditions":"Abdominal Pain","enrollment":32},{"nctId":"NCT04657107","phase":"NA","title":"The Efficacy and Safety of S-ketamine in Elective Cesarean Section","status":"UNKNOWN","sponsor":"Beijing Obstetrics and Gynecology Hospital","startDate":"2020-12-01","conditions":"Anesthesia, Analgesia, Depression","enrollment":402},{"nctId":"NCT04281628","phase":"PHASE4","title":"Comparison Between Low-dose Ketamine Infusion and Intravenous Morphine","status":"COMPLETED","sponsor":"Cairo University","startDate":"2019-02-21","conditions":"Ketamine","enrollment":80},{"nctId":"NCT03618082","phase":"PHASE3","title":"GOAL-Directed ANalgesia (GOALDAN)","status":"UNKNOWN","sponsor":"University Hospital, Clermont-Ferrand","startDate":"2019-06-06","conditions":"Immediate Severe Postoperative Pain, Perioperative Hemodynamic","enrollment":380},{"nctId":"NCT03664622","phase":"NA","title":"Ketamine Versus Morphine Change Pain Profile","status":"COMPLETED","sponsor":"Cairo University","startDate":"2018-09-15","conditions":"Acute Pain","enrollment":160},{"nctId":"NCT03407404","phase":"PHASE2, PHASE3","title":"Comparing Clinical Outcomes Between Ketamine-midazolam and Morphine-midazolam for Continous Sedation in ICU Patients.","status":"TERMINATED","sponsor":"Makerere University","startDate":"2017-10-22","conditions":"Critical Illness","enrollment":124},{"nctId":"NCT04013958","phase":"PHASE3","title":"Comparison of Treatment by IM Ketamine to IV Ketamine in Patients With Renal Colic","status":"UNKNOWN","sponsor":"Tel-Aviv Sourasky Medical Center","startDate":"2019-08-01","conditions":"Acute Pain, Renal Colic","enrollment":100},{"nctId":"NCT02673372","phase":"PHASE4","title":"Geriatric Ketamine for Pain Management Study","status":"COMPLETED","sponsor":"Antonios Likourezos","startDate":"2016-04","conditions":"Pain","enrollment":60},{"nctId":"NCT02430818","phase":"NA","title":"Comparing Ketamine and Morphine in the Treatment of Acute Fracture Pain","status":"TERMINATED","sponsor":"Washington University School of Medicine","startDate":"2015-04","conditions":"Acute Pain, Fractures","enrollment":13},{"nctId":"NCT02033707","phase":"PHASE1","title":"Effects of Hallucinogens and Other Drugs on Mood and Performance","status":"COMPLETED","sponsor":"Johns Hopkins University","startDate":"2014-04","conditions":"Healthy","enrollment":20},{"nctId":"NCT03619785","phase":"PHASE4","title":"US-guided SAPB for Rib Fractures in the ED","status":"UNKNOWN","sponsor":"Andrew A Herring","startDate":"2018-11-06","conditions":"Rib Fractures, Rib Fracture Multiple","enrollment":70},{"nctId":"NCT02591017","phase":"PHASE3","title":"Comparison of Oral Morphine Versus Nasal Ketamine Spray With Chitosan in Cancer Pain Outpatients","status":"TERMINATED","sponsor":"University Hospital, Basel, Switzerland","startDate":"2015-02","conditions":"Cancer: Breakthrough Pain, Cancer: Extreme Pain on Movement","enrollment":11},{"nctId":"NCT03088306","phase":"EARLY_PHASE1","title":"Improving Pain and Reducing Opioid Use (IPaRO) in Lumbar Spine Surgery Patients","status":"COMPLETED","sponsor":"Johns Hopkins University","startDate":"2017-07-01","conditions":"Lumbar Spinal Stenosis, Lumbar Spinal Instability, Lumbar Spine Degeneration","enrollment":49},{"nctId":"NCT02734940","phase":"PHASE4","title":"Multimodal Analgesia in Cardiac Surgery (Pilot Study)","status":"TERMINATED","sponsor":"Virginia Commonwealth University","startDate":"2016-07-11","conditions":"Heart Diseases","enrollment":3},{"nctId":"NCT03580980","phase":"NA","title":"Multimodal Analgesia in Major Abdominal Pediatric Cancer Surgeries","status":"COMPLETED","sponsor":"National Cancer Institute, Egypt","startDate":"2015-04-01","conditions":"Pediatric Cancer, Pain, Postoperative","enrollment":90},{"nctId":"NCT02785003","phase":"PHASE4","title":"Ketamine in Colorectal Surgery","status":"WITHDRAWN","sponsor":"Medical College of Wisconsin","startDate":"2016-07","conditions":"Acute Pain, Pain, Postoperative, Colorectal Surgery","enrollment":""},{"nctId":"NCT03231683","phase":"PHASE2","title":"Use of S+Ketamine During Target-Controlled Intravenous Anaesthesia After Abdominal Hysterectomy","status":"COMPLETED","sponsor":"KK Women's and Children's Hospital","startDate":"2014-03","conditions":"Ketamine, Anesthesia, Morphine","enrollment":90},{"nctId":"NCT01951911","phase":"PHASE3","title":"Effectiveness of Ketamine in Malignant Neuropathic Pain Relief","status":"WITHDRAWN","sponsor":"Haukeland University Hospital","startDate":"2013-09","conditions":"Pain, Intractable","enrollment":""},{"nctId":"NCT00892606","phase":"PHASE4","title":"Methadone Versus Morphine for Orthopedic Surgery Patients","status":"COMPLETED","sponsor":"University of Louisville","startDate":"2009-01","conditions":"Fracture, Pain, Postoperative","enrollment":75},{"nctId":"NCT02479581","phase":"PHASE2","title":"The Safety and Efficacy of the Enhanced Recovery After Surgery(ERAS)Applied on Cardiac Surgery With Cardiopulmonary Bypass","status":"COMPLETED","sponsor":"Xiangya Hospital of Central South University","startDate":"2015-07","conditions":"Valvular Heart Disease","enrollment":226},{"nctId":"NCT02958566","phase":"PHASE4","title":"Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery","status":"UNKNOWN","sponsor":"University of Illinois College of Medicine at Peoria","startDate":"2017-01","conditions":"Colon Cancer, Colon Diverticulosis, Colonic Neoplasms","enrollment":80},{"nctId":"NCT03017248","phase":"PHASE1","title":"Low-dose Ketamine for Acute Pain in the Emergency Department","status":"UNKNOWN","sponsor":"Faculty of Medicine, Sousse","startDate":"2016-01","conditions":"Pain","enrollment":125},{"nctId":"NCT02726828","phase":"PHASE2, PHASE3","title":"intrathecaم Ketamine, Morphine and Both for Lower Abdominal Cancer Surgery Pain","status":"COMPLETED","sponsor":"Assiut University","startDate":"2015-10","conditions":"Postoperative Pain","enrollment":90},{"nctId":"NCT02541396","phase":"PHASE2","title":"A Study Of The Effectiveness Of Wafermine Alone And In Combination With Opioids In Subjects Undergoing Bunionectomy","status":"COMPLETED","sponsor":"iX Biopharma Ltd.","startDate":"2015-10","conditions":"Acute Pain","enrollment":72},{"nctId":"NCT02571491","phase":"PHASE2","title":"Comparison of the Efficacy of Ketamine in Pediatric Patients With Idiopathic Scoliosis After Surgery","status":"COMPLETED","sponsor":"Fundació Sant Joan de Déu","startDate":"2012-01","conditions":"Progressive Infantile Idiopathic Scoliosis","enrollment":48},{"nctId":"NCT02499341","phase":"NA","title":"A Comparison Study Between Ketamine Versus Tramadol for Pain Management After Major Upper Abdominal Surgery","status":"COMPLETED","sponsor":"Attikon Hospital","startDate":"2011-07","conditions":"Postoperative Pain","enrollment":42},{"nctId":"NCT01526525","phase":"PHASE4","title":"Perioperative Electroacupuncture on Postoperative Analgesia in Prostatectomy","status":"COMPLETED","sponsor":"G.Gennimatas General Hospital","startDate":"2009-07","conditions":"Pain, Postoperative","enrollment":70},{"nctId":"NCT00797264","phase":"NA","title":"Ketamine Associated With Morphine PCA After Total Hip Arthroplasty","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2008-11","conditions":"Arthroplasty, Replacement, Hip","enrollment":18},{"nctId":"NCT01807429","phase":"PHASE2, PHASE3","title":"Is Analgesic Effect of Low Dose Ketamine-midazolam the Same as Morphine","status":"COMPLETED","sponsor":"Isfahan University of Medical Sciences","startDate":"2012-12","conditions":"Closed Multiple Fractures of Upper and Lower Limbs","enrollment":236},{"nctId":"NCT01275547","phase":"PHASE2, PHASE3","title":"The Analgesic Effect of Combined Treatment With Intranasal S-ketamine and Intranasal Midazolam","status":"COMPLETED","sponsor":"University Hospital, Basel, Switzerland","startDate":"2011-01","conditions":"Analgesia, Patient-controlled, Spinal Stenosis","enrollment":22},{"nctId":"NCT01439399","phase":"NA","title":"Analgesic Efficacy of Intravenous Lidocaine and/or Ketamine","status":"COMPLETED","sponsor":"University of Lausanne Hospitals","startDate":"2005-12","conditions":"Postoperative Pain","enrollment":52},{"nctId":"NCT01070108","phase":"NA","title":"Escalating Ketamine Doses and Pre-emption","status":"COMPLETED","sponsor":"Tel-Aviv Sourasky Medical Center","startDate":"2007-01","conditions":"Postoperative Pain Management","enrollment":120},{"nctId":"NCT00252122","phase":"PHASE4","title":"Pilot Study on the Effects of Intravenous Ketamine on Acute Pain Crisis in Patients With Sickle Cell Disease","status":"TERMINATED","sponsor":"Children's Hospital of Philadelphia","startDate":"2004-06","conditions":"Sickle Cell Disease","enrollment":3},{"nctId":"NCT00224692","phase":"PHASE3","title":"Analgesic Effect in Children of Low-Dose Ketamine for Mucositis Treated by Patient-Controlled Analgesia With Morphine","status":"TERMINATED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2003-02","conditions":"Cancer, Mucositis","enrollment":50}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":88,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Morphine plus Ketamine","genericName":"Morphine plus Ketamine","companyName":"University of California, San Francisco","companyId":"university-of-california-san-francisco","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Morphine and ketamine together provide analgesia through complementary pathways: morphine acts as an opioid receptor agonist while ketamine blocks NMDA receptors, potentially reducing opioid tolerance and enhancing pain relief. Used for Moderate to severe pain (phase 3 indication under investigation).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}