{"id":"morphine-mouthwash","safety":{"commonSideEffects":[{"rate":null,"effect":"Local irritation or burning sensation"},{"rate":null,"effect":"Systemic opioid effects (drowsiness, dizziness)"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Constipation"}]},"_chembl":{"chemblId":"CHEMBL5665374","moleculeType":null,"molecularWeight":"285.34"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Morphine is a mu-opioid receptor agonist that binds to opioid receptors in the oral cavity and potentially in systemic circulation following mucosal absorption. When applied as a mouthwash, it provides local analgesia for painful oral conditions while allowing some systemic absorption for broader pain relief. This formulation is particularly useful for patients with oral mucositis, ulcers, or other painful oral lesions who may have difficulty swallowing conventional oral medications.","oneSentence":"Morphine mouthwash delivers the opioid analgesic morphine topically to oral mucosa to relieve oral pain and discomfort.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:55:52.296Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Oral pain and mucositis (particularly in cancer patients undergoing chemotherapy or radiotherapy)"},{"name":"Painful oral ulcers and lesions"}]},"trialDetails":[{"nctId":"NCT06875791","phase":"PHASE1, PHASE2","title":"Safety and Efficacy Trial of TV5M01 for Radiation-Induced Mucositis in Head and Neck Cancer Patients.","status":"NOT_YET_RECRUITING","sponsor":"Fundacion Clinica Valle del Lili","startDate":"2025-12-28","conditions":"Squamous Cell Carcinoma of the Head and Neck, Oral Mucositis","enrollment":40},{"nctId":"NCT00357942","phase":"PHASE4","title":"Topical Morphine for Stomatitis-related Pain Induced by Chemotherapy","status":"COMPLETED","sponsor":"Danish University of Pharmaceutical Sciences","startDate":"2006-09","conditions":"Pain, Mucositis","enrollment":72},{"nctId":"NCT01837446","phase":"PHASE2, PHASE3","title":"Morphine Mouthwash for Management of Oral Mucositis in Patients With Head and Neck Cancer","status":"COMPLETED","sponsor":"Isfahan University of Medical Sciences","startDate":"2011-07","conditions":"Stomatitis","enrollment":30},{"nctId":"NCT00613743","phase":"NA","title":"Effect of Topical Morphine (Mouthwash) on Oral Pain Due to Chemo- and/or Radiotherapy Induced Mucositis","status":"COMPLETED","sponsor":"University Hospital, Geneva","startDate":"2007-12","conditions":"Cancer, Mucositis","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"morphine mouthwash","genericName":"morphine mouthwash","companyName":"Danish University of Pharmaceutical Sciences","companyId":"danish-university-of-pharmaceutical-sciences","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Morphine mouthwash delivers the opioid analgesic morphine topically to oral mucosa to relieve oral pain and discomfort. Used for Oral pain and mucositis (particularly in cancer patients undergoing chemotherapy or radiotherapy), Painful oral ulcers and lesions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}