{"id":"morphine-amethocaine","safety":{"commonSideEffects":[{"rate":"10-30%","effect":"Nausea"},{"rate":"5-20%","effect":"Vomiting"},{"rate":"5-15%","effect":"Constipation"},{"rate":"5-10%","effect":"Dizziness"},{"rate":"1-5%","effect":"Respiratory depression"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Morphine works by activating the mu-opioid receptor, which is responsible for the analgesic and euphoric effects. This activation also leads to the release of endogenous opioids, which can contribute to the development of tolerance and dependence.","oneSentence":"Morphine is a potent opioid agonist that binds to opioid receptors in the brain, spinal cord, and other areas to produce analgesia and euphoria.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:22:07.160Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Pain management in cancer patients"},{"name":"Pain management in acute injuries"}]},"trialDetails":[{"nctId":"NCT00213200","phase":"PHASE3","title":"Intravenous and Topical Analgesics for Procedural Pain in Neonates","status":"COMPLETED","sponsor":"The Hospital for Sick Children","startDate":"2003-07","conditions":"Pain, Infant, Newborn","enrollment":108}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"morphine, amethocaine","genericName":"morphine, amethocaine","companyName":"The Hospital for Sick Children","companyId":"the-hospital-for-sick-children","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Morphine is a potent opioid agonist that binds to opioid receptors in the brain, spinal cord, and other areas to produce analgesia and euphoria. Used for Pain management in cancer patients, Pain management in acute injuries.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}