{"id":"morniflumate","rwe":[{"pmid":"37515737","year":"2024","title":"Modeling population pharmacokinetics of morniflumate in healthy Korean men: extending pharmacometrics analysis to niflumic acid, its major active metabolite.","finding":"","journal":"Naunyn-Schmiedeberg's archives of pharmacology","studyType":"Clinical Study"},{"pmid":"35708048","year":"2022","title":"Morniflumate in the treatment of upper airways affections in adults: a review and meta-analysis.","finding":"","journal":"Minerva medica","studyType":"Clinical Study"},{"pmid":"34710544","year":"2021","title":"The solid state of anti-inflammatory morniflumate diniflumate: A cocrystalline salt.","finding":"","journal":"International journal of pharmaceutics","studyType":"Clinical Study"},{"pmid":"31274326","year":"2019","title":"Nose Temperature and Anticorrelation between Recrystallization Kinetics and Molecular Relaxation Dynamics in Amorphous Morniflumate at High Pressure.","finding":"","journal":"Molecular pharmaceutics","studyType":"Clinical Study"},{"pmid":"30849185","year":"2019","title":"Non-steroidal anti-inflammatory drug prescriptions from the 6(th) month of pregnancy: impact of advice from health authorities.","finding":"","journal":"Fundamental & clinical pharmacology","studyType":"Clinical Study"}],"tags":[{"label":"morniflumate","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"M01AX22","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{"safetySignals":[{"llr":116.379,"date":"","count":46,"signal":"Obstructive airways disorder","source":"DrugCentral FAERS","actionTaken":"Reported 46 times (LLR=116)"},{"llr":94.839,"date":"","count":31,"signal":"Benign prostatic hyperplasia","source":"DrugCentral FAERS","actionTaken":"Reported 31 times (LLR=95)"},{"llr":85.468,"date":"","count":41,"signal":"Full blood count abnormal","source":"DrugCentral FAERS","actionTaken":"Reported 41 times (LLR=85)"},{"llr":77.842,"date":"","count":15,"signal":"Congenital hiatus hernia","source":"DrugCentral FAERS","actionTaken":"Reported 15 times (LLR=78)"},{"llr":69.294,"date":"","count":51,"signal":"Wheezing","source":"DrugCentral FAERS","actionTaken":"Reported 51 times (LLR=69)"},{"llr":66.773,"date":"","count":45,"signal":"Chronic obstructive pulmonary disease","source":"DrugCentral FAERS","actionTaken":"Reported 45 times (LLR=67)"},{"llr":66.465,"date":"","count":13,"signal":"Scrotal infection","source":"DrugCentral FAERS","actionTaken":"Reported 13 times (LLR=66)"},{"llr":63.653,"date":"","count":13,"signal":"Perineal infection","source":"DrugCentral FAERS","actionTaken":"Reported 13 times (LLR=64)"},{"llr":63.32,"date":"","count":12,"signal":"Optic nerve operation","source":"DrugCentral FAERS","actionTaken":"Reported 12 times (LLR=63)"},{"llr":62.849,"date":"","count":13,"signal":"Pulmonary vasculitis","source":"DrugCentral FAERS","actionTaken":"Reported 13 times (LLR=63)"},{"llr":61.892,"date":"","count":18,"signal":"Respiratory symptom","source":"DrugCentral FAERS","actionTaken":"Reported 18 times (LLR=62)"},{"llr":59.887,"date":"","count":24,"signal":"Sleep disorder due to a general medical condition","source":"DrugCentral FAERS","actionTaken":"Reported 24 times (LLR=60)"},{"llr":59.372,"date":"","count":15,"signal":"Malignant melanoma in situ","source":"DrugCentral FAERS","actionTaken":"Reported 15 times (LLR=59)"},{"llr":57.221,"date":"","count":13,"signal":"Infected dermal cyst","source":"DrugCentral FAERS","actionTaken":"Reported 13 times (LLR=57)"},{"llr":54.349,"date":"","count":14,"signal":"Tooth injury","source":"DrugCentral FAERS","actionTaken":"Reported 14 times (LLR=54)"}],"commonSideEffects":[{"effect":"Obstructive airways disorder","drugRate":"LLR 116","severity":"common"},{"effect":"Benign prostatic hyperplasia","drugRate":"LLR 95","severity":"common"},{"effect":"Full blood count abnormal","drugRate":"LLR 85","severity":"common"},{"effect":"Congenital hiatus hernia","drugRate":"LLR 78","severity":"common"},{"effect":"Wheezing","drugRate":"LLR 69","severity":"common"},{"effect":"Chronic obstructive pulmonary disease","drugRate":"LLR 67","severity":"common"},{"effect":"Scrotal infection","drugRate":"LLR 66","severity":"common"},{"effect":"Perineal infection","drugRate":"LLR 64","severity":"common"},{"effect":"Optic nerve operation","drugRate":"LLR 63","severity":"common"},{"effect":"Pulmonary vasculitis","drugRate":"LLR 63","severity":"common"},{"effect":"Respiratory symptom","drugRate":"LLR 62","severity":"common"},{"effect":"Sleep disorder due to a general medical condition","drugRate":"LLR 60","severity":"common"},{"effect":"Malignant melanoma in situ","drugRate":"LLR 59","severity":"common"},{"effect":"Infected dermal cyst","drugRate":"LLR 57","severity":"common"},{"effect":"Tooth injury","drugRate":"LLR 54","severity":"common"}]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["morniflumate"],"offLabel":[],"synonyms":["morniflumate"],"timeline":[],"approvals":[],"ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"morniflumate","explanation":"Imagine your body's natural response to injury or infection is like a fire alarm that goes off to alert the immune system. Morniflumate may help reduce the noise of the fire alarm by blocking the enzyme that sends the signal, which could help reduce inflammation and alleviate symptoms.","oneSentence":"Morniflumate is thought to work by inhibiting an enzyme involved in inflammation.","technicalDetail":"Morniflumate is believed to exert its anti-inflammatory effects by inhibiting the activity of cyclooxygenase-2 (COX-2), an enzyme responsible for the production of prostaglandins, which are key mediators of inflammation."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4672","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=MORNIFLUMATE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T14:34:16.277407","biosimilars":[],"competitors":[{"drugName":"nabumetone","drugSlug":"nabumetone","fdaApproval":"1991-12-24","genericCount":14,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"glucosamine","drugSlug":"glucosamine","fdaApproval":"","relationship":"same-class"},{"drugName":"orgotein","drugSlug":"orgotein","fdaApproval":"","relationship":"same-class"}],"genericName":"morniflumate","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"nabumetone","brandName":"nabumetone","genericName":"nabumetone","approvalYear":"1991","relationship":"same-class"},{"drugId":"glucosamine","brandName":"glucosamine","genericName":"glucosamine","approvalYear":"","relationship":"same-class"},{"drugId":"orgotein","brandName":"orgotein","genericName":"orgotein","approvalYear":"","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"005306","UNII":"R133MWH7X1","INN_ID":"4587","RXNORM":"30225","UMLSCUI":"C0066803","ChEMBL_ID":"CHEMBL2105059","KEGG_DRUG":"D05078","DRUGBANK_ID":"DB09285","PUBCHEM_CID":"72106","SNOMEDCT_US":"773471007","MESH_SUPPLEMENTAL_RECORD_UI":"C027859"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":23,"therapeuticAreas":["Immunology"],"atcClassification":{"source":"DrugCentral","atcCode":"M01AX22","allCodes":["M01AX22"]},"biosimilarFilings":[],"recentPublications":[{"date":"2024 Feb","pmid":"37515737","title":"Modeling population pharmacokinetics of morniflumate in healthy Korean men: extending pharmacometrics analysis to niflumic acid, its major active metabolite.","journal":"Naunyn-Schmiedeberg's archives of pharmacology"},{"date":"2022 Oct","pmid":"35708048","title":"Morniflumate in the treatment of upper airways affections in adults: a review and meta-analysis.","journal":"Minerva medica"},{"date":"2021 Dec 15","pmid":"34710544","title":"The solid state of anti-inflammatory morniflumate diniflumate: A cocrystalline salt.","journal":"International journal of pharmaceutics"},{"date":"2019 Aug 5","pmid":"31274326","title":"Nose Temperature and Anticorrelation between Recrystallization Kinetics and Molecular Relaxation Dynamics in Amorphous Morniflumate at High Pressure.","journal":"Molecular pharmaceutics"},{"date":"2019 Oct","pmid":"30849185","title":"Non-steroidal anti-inflammatory drug prescriptions from the 6(th) month of pregnancy: impact of advice from health authorities.","journal":"Fundamental & clinical pharmacology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"MORNIFLUMATE","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Morniflumate is a small molecule with the synonyms Morniflumate, Morniflumato, and Niflumic acid beta-morpholinoethyl ester.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":true,"trials":false,"score":2}}