{"id":"mopv1","safety":{"commonSideEffects":[{"rate":null,"effect":"Vaccine-derived poliovirus (VDPV) shedding"},{"rate":null,"effect":"Mild gastrointestinal symptoms"},{"rate":null,"effect":"Fever"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"mOPV1 contains a live attenuated (weakened) poliovirus type 1 strain that replicates in the intestinal tract, stimulating both mucosal and systemic immune responses. This generates antibodies and cellular immunity against poliovirus type 1, providing protection against infection and disease. The oral route allows for convenient mass vaccination campaigns, particularly in resource-limited settings.","oneSentence":"mOPV1 is a monovalent oral polio vaccine that provides immunization against poliovirus type 1 through oral administration of attenuated virus.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:55:52.782Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of poliomyelitis caused by poliovirus type 1"}]},"trialDetails":[{"nctId":"NCT05644184","phase":"PHASE2","title":"Study of a Novel Type 1 Oral Poliomyelitis Vaccine in Bangladesh","status":"RECRUITING","sponsor":"PATH","startDate":"2023-03-27","conditions":"Poliomyelitis","enrollment":2232},{"nctId":"NCT04529538","phase":"PHASE1","title":"Study of Novel Types 1 and 3 Oral Poliomyelitis Vaccines","status":"COMPLETED","sponsor":"PATH","startDate":"2021-03-26","conditions":"Poliomyelitis","enrollment":226},{"nctId":"NCT03722004","phase":"PHASE4","title":"Monovalent Oral Poliovirus Vaccine Type 1 Intestinal and Humoral Immunity Study","status":"COMPLETED","sponsor":"Centers for Disease Control and Prevention","startDate":"2018-12-18","conditions":"Poliomyelitis","enrollment":1256},{"nctId":"NCT04504539","phase":"NA","title":"Use of mOPV1 in Routine Immunization in Pakistan.","status":"UNKNOWN","sponsor":"Aga Khan University","startDate":"2020-08","conditions":"Oral Polio Vaccine","enrollment":560},{"nctId":"NCT01586572","phase":"NA","title":"Pakistan Short Interval mOPV1 Compared With Standard Interval mOPV1 and bOPV 1,3","status":"COMPLETED","sponsor":"Aga Khan University","startDate":"2012-04","conditions":"Polio","enrollment":1000},{"nctId":"NCT01633216","phase":"PHASE4","title":"Poliovirus Vaccine Trial in Bangladesh","status":"COMPLETED","sponsor":"International Centre for Diarrhoeal Disease Research, Bangladesh","startDate":"2012-05","conditions":"Healthy Infants","enrollment":1000}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":40,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Monovalent type 1 oral poliovirus vaccine"],"phase":"marketed","status":"active","brandName":"mOPV1","genericName":"mOPV1","companyName":"Aga Khan University","companyId":"aga-khan-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"mOPV1 is a monovalent oral polio vaccine that provides immunization against poliovirus type 1 through oral administration of attenuated virus. Used for Prevention of poliomyelitis caused by poliovirus type 1.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}