{"id":"moprolol","rwe":[{"pmid":"41289653","year":"2025","title":"Predicting compounds that interact with the 2 known agonist-induced conformations of the human β1-adrenoceptor.","finding":"","journal":"Molecular pharmacology","studyType":"Clinical Study"},{"pmid":"36043081","year":"2022","title":"Development of a novel chemoenzymatic route to enantiomerically enriched β-adrenolytic agents. A case study toward propranolol, alprenolol, pindolol, carazolol, moprolol, and metoprolol.","finding":"","journal":"RSC advances","studyType":"Clinical Study"},{"pmid":"30900703","year":"2019","title":"Ketoreductase catalyzed stereoselective bioreduction of α-nitro ketones.","finding":"","journal":"Organic & biomolecular chemistry","studyType":"Clinical Study"},{"pmid":"26821612","year":"2016","title":"Chemoenzymatic Route for the Synthesis of (S)-Moprolol, a Potential β-Blocker.","finding":"","journal":"Chirality","studyType":"Clinical Study"},{"pmid":"23194499","year":"2012","title":"A new catalyst for the asymmetric Henry reaction: synthesis of β-nitroethanols in high enantiomeric excess.","finding":"","journal":"Organic letters","studyType":"Clinical Study"}],"tags":[{"label":"moprolol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"(+/-)-moprolol","offLabel":[],"synonyms":["moprolol","(+/-)-Moprolol","dl-Moprolol"],"timeline":[],"approvals":[],"brandName":"(+/-)-Moprolol","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"moprolol","explanation":"Imagine your body's 'fight or flight' response is like a car accelerator pedal. Beta-adrenergic receptors are like the pedal itself, and moprolol helps to slow down or speed up the signal that tells the pedal to accelerate. This can help to regulate heart rate and blood pressure.","oneSentence":"Moprolol works by interacting with beta-adrenergic receptors in the body.","technicalDetail":"Moprolol is a beta-adrenergic receptor antagonist that competes with endogenous catecholamines for binding sites on beta-adrenergic receptors, thereby reducing the effects of sympathetic stimulation on the heart and other tissues."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1839","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=MOPROLOL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T14:34:06.081458","biosimilars":[],"competitors":[],"genericName":"moprolol","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"A94HCH4225","CHEBI":"CHEBI:134974","INN_ID":"4024","UMLSCUI":"C0066791","ChEMBL_ID":"CHEMBL156901","PUBCHEM_CID":"71213","MESH_SUPPLEMENTAL_RECORD_UI":"C009976"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":14,"therapeuticAreas":["Cardiovascular"],"biosimilarFilings":[],"recentPublications":[{"date":"2025 Nov","pmid":"41289653","title":"Predicting compounds that interact with the 2 known agonist-induced conformations of the human β1-adrenoceptor.","journal":"Molecular pharmacology"},{"date":"2022 Aug 4","pmid":"36043081","title":"Development of a novel chemoenzymatic route to enantiomerically enriched β-adrenolytic agents. A case study toward propranolol, alprenolol, pindolol, carazolol, moprolol, and metoprolol.","journal":"RSC advances"},{"date":"2019 Apr 3","pmid":"30900703","title":"Ketoreductase catalyzed stereoselective bioreduction of α-nitro ketones.","journal":"Organic & biomolecular chemistry"},{"date":"2016 Apr","pmid":"26821612","title":"Chemoenzymatic Route for the Synthesis of (S)-Moprolol, a Potential β-Blocker.","journal":"Chirality"},{"date":"2012 Dec 21","pmid":"23194499","title":"A new catalyst for the asymmetric Henry reaction: synthesis of β-nitroethanols in high enantiomeric excess.","journal":"Organic letters"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"(+/-)-Moprolol is a small molecule with synonyms including Levomoprolol, Moprolol, and Moprolol L-Form.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}