{"id":"moperone","rwe":[{"pmid":"19387622","year":"2009","title":"Automated on-line in-tube solid-phase microextraction coupled with HPLC/MS/MS for the determination of butyrophenone derivatives in human plasma.","finding":"","journal":"Analytical and bioanalytical chemistry","studyType":"Clinical Study"},{"pmid":"15519367","year":"2004","title":"Atypical properties of several classes of antipsychotic drugs on the basis of differential induction of Fos-like immunoreactivity in the rat brain.","finding":"","journal":"Life sciences","studyType":"Clinical Study"},{"pmid":"12834224","year":"2003","title":"High-performance liquid chromatographic determination of fluvoxamine and fluvoxamino acid in human plasma.","finding":"","journal":"Analytical sciences : the international journal of the Japan Society for Analytical Chemistry","studyType":"Clinical Study"},{"pmid":"9766869","year":"1998","title":"High-performance liquid chromatographic determination of nemonapride and desmethylnemonapride in human plasma using an electrochemical detection.","finding":"","journal":"Journal of chromatography. B, Biomedical sciences and applications","studyType":"Clinical Study"},{"pmid":"9208371","year":"1997","title":"Inhibitory effect of drugs with a ketone group on reduction of acetohexamide catalyzed by carbonyl reductase from rabbit kidney.","finding":"","journal":"Journal of enzyme inhibition","studyType":"Clinical Study"}],"tags":[{"label":"moperone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"D(3) dopamine receptor","category":"target"},{"label":"DRD3","category":"gene"},{"label":"DRD2","category":"gene"},{"label":"DRD4","category":"gene"},{"label":"N05AD04","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"meperon","offLabel":[],"synonyms":["moperone hydrochloride","moperone","luvatren","luvatrena","meperon","methylperidol","moperone HCl"],"timeline":[],"aiSummary":"Meperon is a small molecule with the synonyms MOPERONA, MOPERONE, MOPERONE, MOPERONE HYDROCHLORIDE, and R 1658.","approvals":[],"brandName":"Meperon","ecosystem":[],"mechanism":{"target":"D(4) dopamine receptor, D(2) dopamine receptor, D(3) dopamine receptor","targets":[{"gene":"DRD3","source":"DrugCentral","target":"D(3) dopamine receptor","protein":"D(3) dopamine receptor"},{"gene":"DRD2","source":"DrugCentral","target":"D(2) dopamine receptor","protein":"D(2) dopamine receptor"},{"gene":"DRD4","source":"DrugCentral","target":"D(4) dopamine receptor","protein":"D(4) dopamine receptor"}],"modality":"Small Molecule","drugClass":"moperone","explanation":"Think of dopamine as a chemical messenger that helps us feel pleasure and motivation. When Moperone blocks the D(3) dopamine receptor, it can reduce the brain's response to dopamine, which may help to decrease symptoms of certain psychiatric conditions. This can be helpful for people who experience excessive motivation or pleasure-seeking behaviors.","oneSentence":"Moperone works by blocking the D(3) dopamine receptor, which is involved in regulating the brain's reward and motivation systems.","technicalDetail":"Moperone acts as a selective antagonist at the D(3) dopamine receptor, which is a subtype of dopamine receptor that is highly expressed in the brain's limbic system. By blocking this receptor, Moperone can modulate the activity of dopamine in the brain and influence various physiological and psychological processes."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1837","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=MOPERONE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:08:24.640775","biosimilars":[],"competitors":[{"drugName":"haloperidol","drugSlug":"haloperidol","fdaApproval":"1967-04-12","genericCount":20,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"droperidol","drugSlug":"droperidol","fdaApproval":"1970-06-11","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"lumateperone","drugSlug":"lumateperone","fdaApproval":"2019-12-20","patentExpiry":"Oct 27, 2039","patentStatus":"Patent protected","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"moperone","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"haloperidol","brandName":"haloperidol","genericName":"haloperidol","approvalYear":"1967","relationship":"same-class"},{"drugId":"droperidol","brandName":"droperidol","genericName":"droperidol","approvalYear":"1970","relationship":"same-class"},{"drugId":"lumateperone","brandName":"lumateperone","genericName":"lumateperone","approvalYear":"2019","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NDDF":"005973","UNII":"OU730881W5","CHEBI":"CHEBI:31865","INN_ID":"1589","UMLSCUI":"C0066787","ChEMBL_ID":"CHEMBL2104700","KEGG_DRUG":"D01105","DRUGBANK_ID":"DB13554","PUBCHEM_CID":"4249","SECONDARY_CAS_RN":"3871-82-7","MESH_SUPPLEMENTAL_RECORD_UI":"C005209"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":0,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"N05AD04","allCodes":["N05AD04"]},"biosimilarFilings":[],"recentPublications":[{"date":"2009 Jun","pmid":"19387622","title":"Automated on-line in-tube solid-phase microextraction coupled with HPLC/MS/MS for the determination of butyrophenone derivatives in human plasma.","journal":"Analytical and bioanalytical chemistry"},{"date":"2004 Nov 26","pmid":"15519367","title":"Atypical properties of several classes of antipsychotic drugs on the basis of differential induction of Fos-like immunoreactivity in the rat brain.","journal":"Life sciences"},{"date":"2003 Jun","pmid":"12834224","title":"High-performance liquid chromatographic determination of fluvoxamine and fluvoxamino acid in human plasma.","journal":"Analytical sciences : the international journal of the Japan Society for Analytical Chemistry"},{"date":"1998 Sep 4","pmid":"9766869","title":"High-performance liquid chromatographic determination of nemonapride and desmethylnemonapride in human plasma using an electrochemical detection.","journal":"Journal of chromatography. B, Biomedical sciences and applications"},{"date":"1997 Feb","pmid":"9208371","title":"Inhibitory effect of drugs with a ketone group on reduction of acetohexamide catalyzed by carbonyl reductase from rabbit kidney.","journal":"Journal of enzyme inhibition"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}