{"id":"montelukast-singulair","safety":{"commonSideEffects":[{"rate":"18","effect":"Headache"},{"rate":"4","effect":"Influenza-like illness"},{"rate":"3","effect":"Abdominal pain"},{"rate":"3","effect":"Cough"},{"rate":null,"effect":"Neuropsychiatric effects (mood changes, suicidality)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Leukotrienes are inflammatory mediators released by mast cells and eosinophils that bind to CysLT1 receptors, causing airway smooth muscle contraction, mucus secretion, and eosinophil recruitment. By antagonizing these receptors, montelukast reduces airway inflammation and improves airflow in asthma and allergic rhinitis. This mechanism is particularly effective in leukotriene-driven inflammatory pathways.","oneSentence":"Montelukast blocks cysteinyl leukotriene receptors (CysLT1) on airway and immune cells, preventing leukotriene-mediated inflammation and bronchoconstriction.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:55:56.328Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Asthma (chronic maintenance treatment)"},{"name":"Allergic rhinitis"},{"name":"Exercise-induced bronchoconstriction"}]},"trialDetails":[{"nctId":"NCT07101640","phase":"PHASE1, PHASE2","title":"PK, Safety and Preliminary Efficacy Study of Montelukast in Critically Ill Infants With Developing Bronchopulmonary Dysplasia","status":"RECRUITING","sponsor":"Duke University","startDate":"2026-02-23","conditions":"Bronchopulmonary Dysplasia (BPD), Premature Births, Critical Illness","enrollment":28},{"nctId":"NCT05922761","phase":"PHASE2","title":"BElumosudil for Bronchiolitis Obliterans 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