{"id":"montelukast-placebo-gran-le","safety":{"commonSideEffects":[{"rate":"18","effect":"Headache"},{"rate":"7","effect":"Diarrhea"},{"rate":"5","effect":"Nausea"},{"rate":"4","effect":"Abdominal pain"},{"rate":"3","effect":"Dyspepsia"}]},"_chembl":{"chemblId":"CHEMBL1200681","moleculeType":"Small molecule","molecularWeight":"608.18"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Montelukast selectively antagonizes cysteinyl leukotriene receptors (CysLT1) on airway smooth muscle and inflammatory cells. By blocking these receptors, it prevents the inflammatory cascade triggered by leukotrienes, which are potent mediators released during allergic and asthmatic responses. This reduces airway edema, mucus secretion, and smooth muscle contraction, improving airflow and reducing asthma symptoms.","oneSentence":"Montelukast is a leukotriene receptor antagonist that blocks cysteinyl leukotriene receptors to reduce airway inflammation and bronchoconstriction.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:55:46.428Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Asthma (maintenance and acute treatment)"},{"name":"Allergic rhinitis"},{"name":"Exercise-induced bronchoconstriction"}]},"trialDetails":[{"nctId":"NCT01304901","phase":"PHASE4","title":"Effect of Addition of Single Dose of Oral Montelukast to Standard Treatment in Acute Asthma in Preschool Children.","status":"COMPLETED","sponsor":"Kecioren Education and Training Hospital","startDate":"2010-04","conditions":"Asthma, Acute Asthma","enrollment":80}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Montelukast placebo granule"],"phase":"marketed","status":"active","brandName":"Montelukast placebo granüle","genericName":"Montelukast placebo granüle","companyName":"Kecioren Education and Training Hospital","companyId":"kecioren-education-and-training-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Montelukast is a leukotriene receptor antagonist that blocks cysteinyl leukotriene receptors to reduce airway inflammation and bronchoconstriction. Used for Asthma (maintenance and acute treatment), Allergic rhinitis, Exercise-induced bronchoconstriction.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}