{"id":"montelukast-mometazon-froat","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Pharyngitis"},{"rate":null,"effect":"Nasal irritation"},{"rate":null,"effect":"Tremor (montelukast-associated)"}]},"_chembl":{"chemblId":"CHEMBL1200681","moleculeType":"Small molecule","molecularWeight":"608.18"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Montelukast is a cysteinyl leukotriene receptor antagonist that prevents bronchoconstriction and inflammation triggered by leukotrienes. Mometasone furoate is an intranasal corticosteroid that suppresses local inflammatory responses in the nasal mucosa. Together, they address both systemic and local airway inflammation through complementary mechanisms.","oneSentence":"This combination blocks leukotriene receptors (montelukast) and reduces airway inflammation via glucocorticoid signaling (mometasone furoate) to treat asthma and allergic rhinitis.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:55:45.324Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Asthma (mild to moderate persistent)"},{"name":"Allergic rhinitis"}]},"trialDetails":[{"nctId":"NCT02565212","phase":"PHASE4","title":"Comparison of the Effects of Nasal Steroids and Montelukast on Olfactory Functions in Patients With Allergic Rhinitis","status":"COMPLETED","sponsor":"Istanbul Training and Research Hospital","startDate":"2014-05","conditions":"Allergic Rhinitis","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Montelukast,mometazon froat","genericName":"Montelukast,mometazon froat","companyName":"Istanbul Training and Research Hospital","companyId":"istanbul-training-and-research-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination blocks leukotriene receptors and reduces inflammatory mediators in the airways while delivering topical corticosteroid anti-inflammatory effects. Used for Asthma (maintenance therapy), Allergic rhinitis.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}