{"id":"montelukast-mixed-with-loratadine","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Somnolence"},{"rate":null,"effect":"Pharyngitis"},{"rate":null,"effect":"Elevated liver enzymes"}]},"_chembl":{"chemblId":"CHEMBL1200681","moleculeType":"Small molecule","molecularWeight":"608.18"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Montelukast is a leukotriene receptor antagonist that inhibits cysteinyl leukotriene-mediated inflammation, while loratadine is a selective H1-receptor antagonist that blocks histamine-induced allergic responses. Together, they target complementary pathways in allergic and inflammatory cascade to provide dual anti-inflammatory and antihistamine effects.","oneSentence":"This combination blocks cysteinyl leukotriene receptors (montelukast) and histamine H1 receptors (loratadine) to reduce allergic inflammation and symptoms.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:22:01.720Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Allergic rhinitis"},{"name":"Asthma (mild to moderate persistent)"},{"name":"Allergic conditions with concurrent asthma"}]},"trialDetails":[{"nctId":"NCT03372473","phase":"PHASE3","title":"Montelukast and Loratadine in Children With Asthma","status":"COMPLETED","sponsor":"Innovacion y Desarrollo de Estrategias en Salud","startDate":"2016-01-10","conditions":"Asthma in Children","enrollment":80}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Montelukast mixed with Loratadine","genericName":"Montelukast mixed with Loratadine","companyName":"Innovacion y Desarrollo de Estrategias en Salud","companyId":"innovacion-y-desarrollo-de-estrategias-en-salud","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination blocks cysteinyl leukotriene receptors (montelukast) and histamine H1 receptors (loratadine) to reduce allergic inflammation and symptoms. Used for Allergic rhinitis, Asthma (mild to moderate persistent), Allergic conditions with concurrent asthma.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}