{"id":"montelukast-drug","safety":{"commonSideEffects":[{"rate":"18","effect":"Headache"},{"rate":"4","effect":"Influenza-like illness"},{"rate":"3","effect":"Abdominal pain"},{"rate":"2","effect":"Cough"},{"rate":"rare but documented","effect":"Neuropsychiatric effects (agitation, anxiety, depression, suicidal ideation)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Leukotrienes are inflammatory mediators released by mast cells and eosinophils that bind to CysLT1 receptors, causing airway smooth muscle contraction, mucus secretion, and eosinophil recruitment. By antagonizing these receptors, montelukast reduces airway inflammation and improves airflow in asthma and allergic rhinitis. This mechanism is particularly effective in aspirin-exacerbated respiratory disease and exercise-induced asthma.","oneSentence":"Montelukast blocks cysteinyl leukotriene receptors (CysLT1) on airway and immune cells, preventing leukotriene-mediated inflammation and bronchoconstriction.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:55:48.783Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Asthma (chronic maintenance and acute treatment)"},{"name":"Allergic rhinitis"},{"name":"Exercise-induced bronchoconstriction"},{"name":"Aspirin-exacerbated respiratory disease"}]},"trialDetails":[{"nctId":"NCT04268498","phase":"PHASE2","title":"A Study of Daratumumab, Carfilzomib, Lenalidomide, and Dexamethasone in Patients With Newly-Diagnosed Multiple Myeloma","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Miami","startDate":"2020-02-11","conditions":"Multiple 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