{"id":"montelukast-and-cetirizine","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Somnolence"},{"rate":null,"effect":"Pharyngitis"},{"rate":null,"effect":"Abdominal pain"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Montelukast is a cysteinyl leukotriene receptor antagonist that inhibits inflammatory mediators involved in asthma and allergic rhinitis. Cetirizine is a selective H1-receptor antagonist that blocks histamine-mediated allergic responses. Together, they target complementary pathways in allergic and inflammatory conditions.","oneSentence":"This combination blocks leukotriene receptors (montelukast) and histamine H1 receptors (cetirizine) to reduce allergic inflammation and symptoms.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:55:49.776Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Allergic rhinitis"},{"name":"Asthma (mild persistent)"},{"name":"Allergic conditions with both leukotriene and histamine involvement"}]},"trialDetails":[{"nctId":"NCT06019728","phase":"PHASE4","title":"A Prospective Study to Investigate Safety and Tolerability of Shorter Infusion of Fabrazyme","status":"COMPLETED","sponsor":"Sanofi","startDate":"2023-11-10","conditions":"Fabry's Disease","enrollment":8},{"nctId":"NCT06535087","phase":"","title":"The Impact of Airway Allergic Diseases on Children's and Parents' Quality of Life","status":"RECRUITING","sponsor":"Wenjing Zhou","startDate":"2024-07-20","conditions":"Pediatric Asthma, Rhinitis, Allergic, Quality of Life","enrollment":600},{"nctId":"NCT00488176","phase":"PHASE4","title":"Comparison of the Effect of Montelukast and Cetirizine on Allergic Inflammation in Children With Allergic Rhinitis","status":"UNKNOWN","sponsor":"Medical University of Lodz","startDate":"2007-04","conditions":"Seasonal Allergic Rhinitis","enrollment":116}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":69,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"montelukast and cetirizine","genericName":"montelukast and cetirizine","companyName":"Medical University of Lodz","companyId":"medical-university-of-lodz","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination blocks leukotriene receptors (montelukast) and histamine H1 receptors (cetirizine) to reduce allergic inflammation and symptoms. Used for Allergic rhinitis, Asthma (mild persistent), Allergic conditions with both leukotriene and histamine involvement.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}