{"id":"mometasone-furoate-oxymetazoline","safety":{"commonSideEffects":[{"rate":null,"effect":"Epistaxis (nosebleed)"},{"rate":null,"effect":"Nasal irritation or dryness"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Pharyngeal irritation"},{"rate":null,"effect":"Rebound congestion (with prolonged oxymetazoline use)"}]},"_chembl":{"chemblId":"CHEMBL1161","moleculeType":"Small molecule","molecularWeight":"521.44"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Mometasone furoate is a topical corticosteroid that binds glucocorticoid receptors to suppress inflammatory cytokines and immune cell infiltration in nasal mucosa. Oxymetazoline is a selective alpha-2 adrenergic agonist that causes vasoconstriction of nasal blood vessels, reducing mucosal edema and nasal airway obstruction. The combination provides both anti-inflammatory and decongestant effects for symptomatic relief.","oneSentence":"Mometasone furoate reduces nasal inflammation via glucocorticoid receptor activation, while oxymetazoline constricts nasal blood vessels to reduce congestion.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:55:42.314Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Nasal congestion and inflammation associated with allergic rhinitis or rhinosinusitis"}]},"trialDetails":[{"nctId":"NCT00552110","phase":"PHASE2","title":"Study of Mometasone Furoate Nasal Spray and Oxymetazoline Nasal Spray Given Together Once A Day To Treat Seasonal Allergic Rhinitis (P04500)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2007-07","conditions":"Seasonal Allergic Rhinitis","enrollment":707},{"nctId":"NCT05348148","phase":"NA","title":"Comparison of the Effects for Lightening the Shiners Among Different Treatments for Rhinitis","status":"RECRUITING","sponsor":"Camillians Saint Mary's Hospital Luodong","startDate":"2020-06-16","conditions":"Allergic Rhinitis, Vasomotor Rhinitis","enrollment":450},{"nctId":"NCT03590912","phase":"PHASE4","title":"Efficacy and Cost Analysis of Steroids in Treatment of Otitis Media With Effusion","status":"COMPLETED","sponsor":"Lumbini Medical College","startDate":"2018-09-05","conditions":"Otitis Media With Effusion","enrollment":160},{"nctId":"NCT02154334","phase":"PHASE1","title":"Study to Assess the Effects of Allergic Rhinitis and Co-administration of Mometasone or Oxymetazoline on the Pharmacokinetics, Safety, and Tolerability of Intranasal Esketamine","status":"COMPLETED","sponsor":"Janssen Research & Development, LLC","startDate":"2014-06","conditions":"Allergic Rhinitis","enrollment":47},{"nctId":"NCT02559440","phase":"PHASE4","title":"Mometasone Furoate and Oxymetazoline in the Treatment of Adenoid Hypertrophy","status":"COMPLETED","sponsor":"Guangzhou Women and Children's Medical Center","startDate":"2014-02","conditions":"Adenoidal Hypertrophy","enrollment":240},{"nctId":"NCT00746330","phase":"PHASE2","title":"Single Dose Study of the Effect of Formoterol Fumarate in Combination With Mometasone Furoate Inhaled Via a Pressurized Metered Dose Inhaler (pMDI) in Children Aged 5-11 Years Old With Persistent Asthma","status":"COMPLETED","sponsor":"Novartis","startDate":"2008-08","conditions":"Asthma","enrollment":32}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["NASONEX + Oxymetazoline Hydrochloride Spray"],"phase":"marketed","status":"active","brandName":"mometasone furoate + Oxymetazoline","genericName":"mometasone furoate + Oxymetazoline","companyName":"Guangzhou Women and Children's Medical Center","companyId":"guangzhou-women-and-children-s-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Mometasone furoate reduces nasal inflammation via glucocorticoid receptor activation, while oxymetazoline constricts nasal blood vessels to reduce congestion. Used for Nasal congestion and inflammation associated with allergic rhinitis or rhinosinusitis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}