{"id":"mometasone-furoate-ns","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Pharyngitis"},{"rate":null,"effect":"Epistaxis"},{"rate":null,"effect":"Nasal irritation"},{"rate":null,"effect":"Dysgeusia"}]},"_chembl":{"chemblId":"CHEMBL1161","moleculeType":"Small molecule","molecularWeight":"521.44"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Mometasone furoate binds to glucocorticoid receptors in nasal tissue, inhibiting the production and release of inflammatory cytokines, chemokines, and adhesion molecules. This reduces nasal inflammation, congestion, and mucus production. As a nasal spray (NS) formulation, it delivers the active corticosteroid directly to the site of inflammation with minimal systemic absorption.","oneSentence":"Mometasone furoate is a corticosteroid that reduces inflammation in the nasal passages by suppressing immune responses and decreasing inflammatory mediator release.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:21:57.947Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Allergic rhinitis"},{"name":"Nasal polyps"},{"name":"Chronic rhinosinusitis"}]},"trialDetails":[{"nctId":"NCT02318303","phase":"PHASE2","title":"To Study GSP 301 in Patients With Seasonal Allergic Rhinitis","status":"COMPLETED","sponsor":"Glenmark Pharmaceuticals Ltd. India","startDate":"2014-12","conditions":"Seasonal Allergic Rhinitis","enrollment":1111},{"nctId":"NCT02709538","phase":"PHASE3","title":"Long Term Safety and Efficacy of Fixed Dose Combination GSP 301 Nasal Spray (NS) in the Treatment of Perennial Allergic Rhinitis (PAR)","status":"COMPLETED","sponsor":"Glenmark Specialty S.A.","startDate":"2016-04","conditions":"Perennial Allergic Rhinitis","enrollment":601},{"nctId":"NCT03463031","phase":"PHASE3","title":"Efficacy and Safety of GSP 301 Nasal Spray in Children (Aged 6 to Under 12 Years) With Seasonal Allergic Rhinitis (SAR)","status":"COMPLETED","sponsor":"Glenmark Specialty S.A.","startDate":"2018-03-16","conditions":"Seasonal Allergic Rhinitis (SAR)","enrollment":446},{"nctId":"NCT02631551","phase":"PHASE3","title":"Efficacy and Safety of Fixed Dose Combination GSP 301 Nasal Spray (NS) in the Treatment of Seasonal Allergic Rhinitis (SAR)","status":"COMPLETED","sponsor":"Glenmark Specialty S.A.","startDate":"2016-03","conditions":"Seasonal Allergic Rhinitis","enrollment":1180},{"nctId":"NCT03444506","phase":"PHASE2","title":"Efficacy and Safety of Fixed Dose Combination (FDC) of Olopatadine Hydrochloride and Mometasone Furoate Nasal Spray (Molo; Also Referred as GSP 301) in the Treatment of Seasonal Allergic Rhinitis (SAR)","status":"COMPLETED","sponsor":"Glenmark Pharmaceuticals Ltd. India","startDate":"2014-01-27","conditions":"Seasonal Allergic Rhinitis","enrollment":180},{"nctId":"NCT02870205","phase":"PHASE3","title":"Efficacy and Safety of GSP 301 Nasal Spray in the Treatment of Seasonal Allergic Rhinitis (SAR)","status":"COMPLETED","sponsor":"Glenmark Specialty S.A.","startDate":"2016-08","conditions":"Seasonal Allergic Rhinitis (SAR)","enrollment":1176}],"_emaApprovals":[],"_faersSignals":[{"count":1,"reaction":"HEADACHE"}],"_approvalHistory":[],"publicationCount":5,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Mometasone furoate NS","genericName":"Mometasone furoate NS","companyName":"Glenmark Specialty S.A.","companyId":"glenmark-specialty-s-a","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Mometasone furoate is a corticosteroid that reduces inflammation in the nasal passages by suppressing immune responses and decreasing inflammatory mediator release. Used for Allergic rhinitis, Nasal polyps, Chronic rhinosinusitis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}