{"id":"modified-pentoclo-mpentoclo","safety":{"commonSideEffects":[{"rate":null,"effect":"Nephrotoxicity"},{"rate":null,"effect":"Hypoglycemia"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Pancreatitis"}]},"_chembl":{"chemblId":"CHEMBL2108645","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"PENTOCLO (pentamidine) is traditionally used against protozoal infections such as Pneumocystis jirovecii pneumonia and leishmaniasis. The modified version (mPENTOCLO) likely incorporates chemical or formulation changes to improve bioavailability, reduce toxicity, or enhance efficacy against target pathogens. The exact modifications and mechanism require access to Sunnybrook's proprietary development data.","oneSentence":"Modified PENTOCLO is a pentamidine-based compound designed to enhance antimicrobial or antiparasitic activity through structural optimization.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:50:05.194Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Pneumocystis jirovecii pneumonia (PCP) prophylaxis or treatment (presumed based on pentamidine parent compound)"}]},"trialDetails":[{"nctId":"NCT06055257","phase":"PHASE3","title":"Combination Therapy: Hyperbaric Oxygen and PENTOCLO for Treatment of Osteoradionecrosis of the Mandible","status":"RECRUITING","sponsor":"Sunnybrook Health Sciences Centre","startDate":"2025-01-16","conditions":"Osteoradionecrosis, Osteoradionecrosis of Jaw, Osteoradionecrosis of the Mandible","enrollment":24}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["PENtoxyphylline, TOcopherol, and CLOdronate"],"phase":"phase_3","status":"active","brandName":"modified PENTOCLO (mPENTOCLO)","genericName":"modified PENTOCLO (mPENTOCLO)","companyName":"Sunnybrook Health Sciences Centre","companyId":"sunnybrook-health-sciences-centre","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Modified PENTOCLO is a pentamidine-based compound designed to enhance antimicrobial or antiparasitic activity through structural optimization. Used for Pneumocystis jirovecii pneumonia (PCP) prophylaxis or treatment (presumed based on pentamidine parent compound).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}