{"id":"mmrv-2006-process","safety":{"commonSideEffects":[{"rate":"15–20%","effect":"Injection site reactions (erythema, swelling, tenderness)"},{"rate":"10–15%","effect":"Fever"},{"rate":"3–5%","effect":"Rash"},{"rate":"1–2%","effect":"Varicella-like rash at injection site"}]},"_chembl":{"chemblId":"CHEMBL586516","moleculeType":"Small molecule","molecularWeight":"419.36"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"MMRV combines the Merck MMRII (measles, mumps, rubella) vaccine with the Varivax (varicella) vaccine into a single formulation. Each component contains live attenuated virus strains that replicate in vaccinated individuals, triggering both humoral and cellular immune responses without causing disease. This provides protection against all four viral infections with a single injection.","oneSentence":"MMRV is a live attenuated combination vaccine that provides immunization against measles, mumps, rubella, and varicella by stimulating immune responses to all four viruses.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:21:49.417Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of measles, mumps, rubella, and varicella in children aged 12 months and older"}]},"trialDetails":[{"nctId":"NCT01536405","phase":"PHASE3","title":"Safety, Tolerability, and Immunogenicity of Measles, Mumps, Rubella, and Varicella (MMRV) Vaccine Made With an Alternative Manufacturing Process (AMP)(V221-027)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2012-06-05","conditions":"Measles, Mumps, Rubella","enrollment":1412}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["ProQuad™"],"phase":"phase_3","status":"active","brandName":"MMRV (2006 process)","genericName":"MMRV (2006 process)","companyName":"Merck Sharp & Dohme LLC","companyId":"merck","modality":"Biologic","firstApprovalDate":"","aiSummary":"MMRV is a live attenuated combination vaccine that provides immunization against measles, mumps, rubella, and varicella by stimulating immune responses to all four viruses. Used for Prevention of measles, mumps, rubella, and varicella in children aged 12 months and older.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}