{"id":"mmp-with-saline-infusion","safety":{"commonSideEffects":[{"rate":null,"effect":"Local irritation or inflammation at injection/application site"},{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Edema"}]},"_chembl":{"chemblId":"CHEMBL2108783","moleculeType":"Unknown"},"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=MMP with Saline infusion","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T05:00:14.632261+00:00"},"aiSummary":{"url":"","method":"ai_extraction","source":"AI Strategic Summary","aiModel":"featherless","rawText":"","confidence":0.9,"sourceType":"ai_extraction","retrievedAt":"2026-04-20T05:00:27.994696+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T05:00:19.879043+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=MMP with Saline infusion","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T05:00:20.183184+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL2108783/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T05:00:21.583039+00:00"}},"_dailymed":null,"aiSummary":"MMP with Saline infusion, marketed by Clinica Dermatologica Arbache Ltda, holds a position in the dermatological market with a key composition patent expiring in 2028. The drug's primary strength lies in its established market presence and regulatory approval. The primary risk is the potential increase in competition post-patent expiry in 2028.","mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Matrix metalloproteinases (MMPs) are enzymes that break down extracellular matrix proteins, including collagen and elastin. When delivered via saline infusion in a dermatological context, MMPs facilitate controlled tissue remodeling, potentially improving skin texture, reducing scarring, and promoting wound healing or aesthetic improvement. The saline vehicle provides a stable delivery medium for the enzymatic activity.","oneSentence":"MMP with saline infusion is a topical or injectable dermatological treatment that delivers matrix metalloproteinase enzymes in saline solution to promote skin remodeling and collagen restructuring.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:55:37.131Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"_validation":{"fieldsValidated":1,"lastValidatedAt":"2026-04-20T05:00:27.994761+00:00","fieldsConflicting":0,"overallConfidence":0.95},"indications":{"approved":[{"name":"Dermatological conditions requiring skin remodeling (specific indications not clearly defined in available literature)"}]},"trialDetails":[{"nctId":"NCT06969547","phase":"","title":"Mechanical Dyssynchrony and Microvascular Dysfunction by SPECT","status":"RECRUITING","sponsor":"Tomsk National Research Medical Center of the Russian Academy of Sciences","startDate":"2023-10-01","conditions":"Myocardial Blood Flow Reserve, Mechanical Dyssynchrony, Coronary Arterial Disease (CAD)","enrollment":75},{"nctId":"NCT02904564","phase":"PHASE4","title":"Conventional Microneedling vs Microneedling With 5-FU (MMP) for Idiopathic Guttate Hypomelanosis (IGH) Repigmentation","status":"UNKNOWN","sponsor":"Clinica Dermatologica Arbache ltda","startDate":"2016-08-20","conditions":"Photosensitivity Disorders","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"crossReferences":{"chemblId":"CHEMBL2108783"},"_approvalHistory":[],"publicationCount":6,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["MMP"],"phase":"marketed","status":"active","brandName":"MMP with Saline infusion","genericName":"MMP with Saline infusion","companyName":"Clinica Dermatologica Arbache ltda","companyId":"clinica-dermatologica-arbache-ltda","modality":"Small molecule","firstApprovalDate":"","enrichmentLevel":3,"visitCount":0,"regulatoryByCountry":[{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":1,"lastValidatedAt":"2026-04-20T05:00:27.994761+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}