{"id":"mmp-with-5-fu","safety":{"commonSideEffects":[{"rate":null,"effect":"Local irritation/erythema"},{"rate":null,"effect":"Photosensitivity"},{"rate":null,"effect":"Burning/stinging at application site"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This combination leverages 5-FU's cytotoxic effects on rapidly dividing cells (commonly used in actinic keratosis and other skin cancers) while MMP (matrix metalloproteinase) components may modulate tissue remodeling and enhance drug penetration or efficacy. The exact mechanism of the MMP component in this formulation is not well-characterized in standard literature, suggesting this may be a proprietary or regional formulation.","oneSentence":"MMP with 5-FU is a topical combination therapy that uses matrix metalloproteinase modulation alongside 5-fluorouracil chemotherapy to treat skin lesions.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:55:34.777Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Actinic keratosis (presumed, based on 5-FU indication)"},{"name":"Other skin lesions (specific indications not clearly documented)"}]},"trialDetails":[{"nctId":"NCT02904564","phase":"PHASE4","title":"Conventional Microneedling vs Microneedling With 5-FU (MMP) for Idiopathic Guttate Hypomelanosis (IGH) Repigmentation","status":"UNKNOWN","sponsor":"Clinica Dermatologica Arbache ltda","startDate":"2016-08-20","conditions":"Photosensitivity Disorders","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":137,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["5-fluorouracil","drug delivery","drug infusion","microinfusion of medication percutaneously","MMP"],"phase":"marketed","status":"active","brandName":"MMP with 5-FU","genericName":"MMP with 5-FU","companyName":"Clinica Dermatologica Arbache ltda","companyId":"clinica-dermatologica-arbache-ltda","modality":"Small molecule","firstApprovalDate":"","aiSummary":"MMP with 5-FU is a topical combination therapy that uses matrix metalloproteinase modulation alongside 5-fluorouracil chemotherapy to treat skin lesions. Used for Actinic keratosis (presumed, based on 5-FU indication), Other skin lesions (specific indications not clearly documented).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}