{"id":"mmc-in-trabeculectomy","safety":{"commonSideEffects":[{"rate":null,"effect":"Corneal toxicity / epithelial defects"},{"rate":null,"effect":"Hypotony (low intraocular pressure)"},{"rate":null,"effect":"Bleb-related infections"},{"rate":null,"effect":"Cataract progression"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"MMC is applied topically during trabeculectomy (glaucoma filtration surgery) to suppress fibroblast activity and reduce postoperative scarring of the surgical site. By limiting scar tissue formation, MMC helps maintain the patency of the drainage bleb and improves long-term surgical success rates. This mechanism is particularly important in high-risk patients prone to excessive wound healing.","oneSentence":"Mitomycin C (MMC) is an alkylating agent that inhibits fibroblast proliferation and collagen synthesis to prevent scarring during trabeculectomy surgery.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:21:57.453Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Adjunctive use in trabeculectomy for primary open-angle glaucoma"},{"name":"Adjunctive use in trabeculectomy for secondary glaucomas"}]},"trialDetails":[{"nctId":"NCT07496957","phase":"NA","title":"Preserflo MicroShunt Versus Trabeculectomy","status":"RECRUITING","sponsor":"Medical University of Bialystok","startDate":"2026-03-01","conditions":"GLAUCOMA 1, OPEN ANGLE, D (Disorder)","enrollment":100},{"nctId":"NCT07358650","phase":"NA","title":"Clinical Study Evaluating the Safety and Performance of the MIST Device for Intraocular Pressure Reduction in Patients With Primary Open-Angle Glaucoma","status":"RECRUITING","sponsor":"Hexiris Inc","startDate":"2026-01-15","conditions":"Primary Open Angle Glaucoma","enrollment":25},{"nctId":"NCT07152132","phase":"NA","title":"SCTSC Versus Trabeculectomy in Medically Uncontrolled Open-Angle Glaucoma in Pseudophakic Patients","status":"RECRUITING","sponsor":"Minia University","startDate":"2025-07-20","conditions":"Glaucoma, Open Angle","enrollment":50},{"nctId":"NCT03648814","phase":"NA","title":"Intracameral Versus Intravitreal Bevacizumab Injection in NVG: RCT","status":"RECRUITING","sponsor":"Prince of Songkla University","startDate":"2018-08-01","conditions":"Glaucoma, Neovascular, Vascular Endothelial Growth Factor Overexpression","enrollment":40},{"nctId":"NCT07034651","phase":"NA","title":"Electron Microscopic Examination of Iris Tissue in Buphthalmos","status":"COMPLETED","sponsor":"Assiut University","startDate":"2024-06-01","conditions":"Iris Diseases","enrollment":20},{"nctId":"NCT06925412","phase":"NA","title":"Sponge Application of MMC Versus Suntenon Injection in Trabeculectomy","status":"COMPLETED","sponsor":"Al-Azhar University","startDate":"2024-02-01","conditions":"Trabeculectomy, Glaucoma","enrollment":50},{"nctId":"NCT04727411","phase":"NA","title":"Analysis of Conjunctival Changes as Indicators for Ab-interno Gelatin Microstent Implantation Surgery Outcomes","status":"COMPLETED","sponsor":"Hospital Clinic of Barcelona","startDate":"2021-01-01","conditions":"Glaucoma, Glaucoma Open-Angle Primary","enrollment":39},{"nctId":"NCT03875911","phase":"PHASE4","title":"Comparing Preoperative Injection of Mitomycin-C vs. Intraoperative Injection of Mitomycin-C vs. Topical Application of Mitomycin-C (Conventional Use) in Trabeculectomy","status":"TERMINATED","sponsor":"University of California, Los Angeles","startDate":"2019-03-30","conditions":"Glaucoma Open-Angle Primary, Glaucoma, Open Angle Glaucoma","enrollment":19},{"nctId":"NCT03548805","phase":"NA","title":"Ologen® Collagen Matrix Versus Mitomycin-C in Patients With Juvenile-onset Open Angle Glaucoma","status":"COMPLETED","sponsor":"L.V. 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